WormBase Tree Display for Gene: WBGene00003225
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| WBGene00003225 | SMap | S_parent | Sequence | T07C4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mev-1 | Person_evidence | WBPerson286 | |||||
| Sequence_name | T07C4.7 | ||||||||
| Molecular_name | T07C4.7a | ||||||||
| T07C4.7a.1 | |||||||||
| CE00598 | |||||||||
| T07C4.7b | |||||||||
| CE50785 | |||||||||
| T07C4.7b.1 | |||||||||
| Other_name | cyt-1 | ||||||||
| sdhc-1 | Person_evidence | WBPerson205 | |||||||
| CELE_T07C4.7 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | mev-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 19 Jul 2006 13:37:01 | WBPerson2970 | Name_change | Other_name | sdhc-1 | ||||
| Status | Live | ||||||||
| Gene_info (12) | |||||||||
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||
| DOID:0080533 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||||
| DOID:0050773 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||||
| DOID:9253 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||||
| Disease_relevance | C. elegans is used as a model system to study the molecular mechanisms underlying diabetic hyperglycemia-induced reduction in life-span; studies in the mev-1 mutant strain of C. elegans, which carries a mutation in the cytochrome b subunit of succinate dehydrogenase and displays increased mitochondrial reactive oxygen species (ROS) generation, in analogy to the situation observed in insulin-resistance, indicate that an impaired proteosomal degradation system and accumulation of misfolded/unfolded proteins underlies glucose induced life-span reduction. | Homo sapiens | Paper_evidence | WBPaper00041961 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 11 Mar 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T07C4.7a | |||||||
| T07C4.7b | |||||||||
| Corresponding_transcript | T07C4.7a.1 | ||||||||
| T07C4.7b.1 | |||||||||
| Other_sequence (104) | |||||||||
| Associated_feature | WBsf645557 | ||||||||
| WBsf659493 | |||||||||
| WBsf659494 | |||||||||
| WBsf225708 | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern | Expr4391 | ||||||||
| Expr1027219 | |||||||||
| Expr1031524 | |||||||||
| Expr1156340 | |||||||||
| Expr2013540 | |||||||||
| Expr2031774 | |||||||||
| Drives_construct | WBCnstr00000780 | ||||||||
| WBCnstr00036176 | |||||||||
| WBCnstr00042214 | |||||||||
| Construct_product | WBCnstr00000780 | ||||||||
| WBCnstr00036176 | |||||||||
| WBCnstr00042214 | |||||||||
| Regulate_expr_cluster | WBPaper00046217:mev-1(kn1)_downregulated | ||||||||
| WBPaper00046217:mev-1(kn1)_upregulated | |||||||||
| Antibody | WBAntibody00000642 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (95) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000014 | |||||||||
| WBbiopr:00000065 | |||||||||
| Map_info | Map | III | Position | 2.348 | |||||
| Well_ordered | |||||||||
| Positive | Positive_clone | T07C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Negative | Negative_clone | C38H2 | |||||||
| Mapping_data | Multi_point | 1752 | |||||||
| 1753 | |||||||||
| 1754 | |||||||||
| 1755 | |||||||||
| 1756 | |||||||||
| 1757 | |||||||||
| 1824 | |||||||||
| 2407 | |||||||||
| 3547 | |||||||||
| Reference (248) | |||||||||
| Remark | Rescue data communicated by Hartman PS | ||||||||
| extracted from Ishii et al. (1998) | |||||||||
| Positive_clone is based on transformation rescue, mutant sequence [Ishii N, Hartman PS][030403 ck1] | |||||||||
| Negative_clone is based on no rescue [Ishii N, Hartman PS][030403 ck1] | |||||||||
| [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (2.32414) | |||||||||
| Method | Gene |
