WormBase Tree Display for Gene: WBGene00003183
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| WBGene00003183 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mei-1 | Person_evidence | WBPerson314 | |||||
| Sequence_name | T01G9.5 | ||||||||
| Molecular_name | T01G9.5a | ||||||||
| T01G9.5a.1 | |||||||||
| CE06342 | |||||||||
| T01G9.5b | |||||||||
| CE32479 | |||||||||
| T01G9.5b.1 | |||||||||
| Other_name | CELE_T01G9.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mei-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mei | ||||||||
| Allele (44) | |||||||||
| Legacy_information | [C.elegansII] b284 : Mel, embryonic lethality, abnormal oocyte meiosis leading to lethal aneuploidy. Normal male meiosis.OA>20: ct46dm,ts (gf allele, normal meiosis followed by abnormal mitoses), intragenic revertants of ct46 eg ct44ct99 (putative null, abnormal meiosis), ct46ct82 (antimorphic), ct46ct103 (viable, weak Him), additional phenotypic classes. See also mei-2, mel-26, zyg-9. Cloned: two transcripts encoding 472 and 475 aa predicted proteins with similarity to ATPases. Antibody stains meiotic spindles I and II. [Mains et al. 1990, Clark-Maguire and Mains 1994; HR] | ||||||||
| Strain | WBStrain00003002 | ||||||||
| WBStrain00026463 | |||||||||
| WBStrain00036667 | |||||||||
| WBStrain00007388 | |||||||||
| WBStrain00008444 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (64) | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00021334 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00011175 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00010047 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00017981 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00016045 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00010557 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mei-1 encodes, by alternative splicing, two slightly different isoforms of an ortholog of the catalytic subunit of katanin (OMIM:606696) that is required for oocyte meiotic spindle formation, for stable association of the meiosis I spindle with the oocyte cortex, and for microtubule severing; MEI-1 exists in a physical complex with MEI-2 at the polar ends of meiotic spindle microtubules and meiotic chromatin; MEI-1 must be inactivated for meiosis to give way to mitosis, and ectopic expression of MEI-1/MEI-2 during mitosis is normally lethal; MEI-1 is bound by the BTB protein MEL-26 (both in vivo and in vitro), which physically links MEI-1 to CUL-3 (an E3 ubiquitin ligase); CUL-3, in turn, promotes MEI-1 proteolysis by the 26S proteasome during the transition from meiosis to mitosis; the MEI-1/MEI-2 complex requires tubules containing the germline-enriched beta tubulin TBB-2 in vivo, but does not require tubules made from TBB-2's (superficially) redundant paralog TBB-1. | Paper_evidence (11) | ||||||
| Person_evidence | WBPerson399 | ||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 27 Jul 2005 00:00:00 | ||||||||
| Automated_description | Enables several functions, including ATP binding activity; MATH domain binding activity; and microtubule severing ATPase activity. Involved in several processes, including cytoskeleton organization; female meiotic nuclear division; and negative regulation of meiotic spindle elongation. Located in meiotic spindle pole and nucleus. Part of chromatin and katanin complex. Expressed in ciliated neurons; germ line; and head neurons. Is an ortholog of human KATNA1 (katanin catalytic subunit A1) and KATNAL1 (katanin catalytic subunit A1 like 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T01G9.5a | |||||||
| T01G9.5b | |||||||||
| Corresponding_CDS_history | T01G9.5:wp90 | ||||||||
| Corresponding_transcript | T01G9.5a.1 | ||||||||
| T01G9.5b.1 | |||||||||
| Other_sequence (30) | |||||||||
| Associated_feature | WBsf643522 | ||||||||
| WBsf654808 | |||||||||
| WBsf656622 | |||||||||
| WBsf218140 | |||||||||
| WBsf218141 | |||||||||
| WBsf218142 | |||||||||
| Experimental_info | RNAi_result (30) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00003502 | ||||||||
| WBCnstr00022604 | |||||||||
| WBCnstr00036188 | |||||||||
| Construct_product | WBCnstr00010904 | ||||||||
| WBCnstr00013242 | |||||||||
| WBCnstr00036188 | |||||||||
| Antibody | WBAntibody00000081 | ||||||||
| WBAntibody00000664 | |||||||||
| WBAntibody00000938 | |||||||||
| WBAntibody00000985 | |||||||||
| WBAntibody00001037 | |||||||||
| WBAntibody00001173 | |||||||||
| WBAntibody00001201 | |||||||||
| WBAntibody00001919 | |||||||||
| WBAntibody00002457 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction (381) | |||||||||
| Map_info | Map | I | Position | 2.70625 | Error | 0.000689 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | gaDp1 | |||||||
| Positive_clone | C14H7 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| T01G9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 2513 | |||||||
| Multi_point | 993 | ||||||||
| 1220 | |||||||||
| 1221 | |||||||||
| 1764 | |||||||||
| 1765 | |||||||||
| 2288 | |||||||||
| 5664 | |||||||||
| Pos_neg_data | 7285 | ||||||||
| 6820 | |||||||||
| 3737 | |||||||||
| Reference (126) | |||||||||
| Remark | mains@ucalgary.ca catalytic subunit of the microtubule-severing protein "katanin". Srayko et al. (2000) Genes Develop. 14:1072-1084 | ||||||||
| Method | Gene |
