| WBGene00003173 | SMap | S_parent | Sequence | C50H2 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | mec-9 | Person_evidence | WBPerson95 |
| | | Sequence_name | C50H2.3 |
| | | Molecular_name | C50H2.3a |
| | | | C50H2.3a.1 |
| | | | CE05481 |
| | | | C50H2.3b |
| | | | CE08916 |
| | | | C50H2.3b.1 |
| | | Other_name | CELE_C50H2.3 | Accession_evidence | NDB | BX284605 |
| | | Public_name | mec-9 |
| | DB_info | Database | WormQTL | gene | WBGene00003173 |
| | | | WormFlux | gene | WBGene00003173 |
| | | | NDB | locus_tag | CELE_C50H2.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00003173|UniProtKB=Q18761 |
| | | | | family | PTHR24039 |
| | | | NCBI | gene | 179382 |
| | | | RefSeq | protein | NM_001269224.3 |
| | | | | | NM_001269225.3 |
| | | | TREEFAM | TREEFAM_ID | TF316678 |
| | | | TrEMBL | UniProtAcc | G3MVG9 |
| | | | | | Q18761 |
| | | | UniProt_GCRP | UniProtAcc | Q18761 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mec |
| | Allele (119) |
| | Legacy_information | u27amber : touch insensitive lethargic. ES2 ME2. NA > 20 (e1494 u164amber etc.). |
| | | [C.elegansII] u27amb : touch insensitive lethargic. ES2 ME2. OA>30: e1494, e1852, u164amb etc. Cloned: 2 kb and 3 kb transcripts, transpliced to SL1 and SL2, encode protein with Kunitztype serine protease inhibitor domains, EGF-like repeats. mec-9:GFP expressed in touch cells and PVD (3kb promoter) or more extensively (2kb promoter). [Chalfie and Au 1989; Huang and Chalfie 1994; TU] |
| | Strain | WBStrain00032822 |
| | | WBStrain00004348 |
| | | WBStrain00006234 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Ortholog (21) |
| | Paralog (31) |
| | Structured_description | Concise_description | mec-9 encodes a predicted extracellular protein containing six EGF-like repeats,five Kunitz-type protease inhibitor domains, and a glutamic acid-rich region possibly involved in protein-protein interactions; mec-9 encodes two proteins, only one of which, MEC-9L, appears to be required for normal mechanosensory response to gentle touch and proper functioning of the touch receptor neurons; mec-9 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-9L is expressed and secreted by the touch receptor neurons. | Paper_evidence | WBPaper00002379 |
| | | | | | WBPaper00005666 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable calcium ion binding activity and serine-type endopeptidase inhibitor activity. Involved in positive regulation of multicellular organismal process and response to mechanical stimulus. Predicted to be located in extracellular region. Expressed in PVDL; PVDR; head neurons; touch receptor neurons; and ventral cord neurons. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C50H2.3a |
| | | C50H2.3b |
| | Corresponding_CDS_history | C50H2.3a:wp144 |
| | | C50H2.3b:wp144 |
| | Corresponding_transcript | C50H2.3a.1 |
| | | C50H2.3b.1 |
| | Other_sequence (14) |
| | Associated_feature | WBsf669266 |
| | | WBsf669267 |
| | | WBsf669268 |
| | | WBsf1001008 |
| | | WBsf1020239 |
| | | WBsf234297 |
| Experimental_info | RNAi_result | WBRNAi00042982 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00012263 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00067621 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00112683 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089014 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr268 |
| | | Expr1026433 |
| | | Expr1146947 |
| | | Expr2013503 |
| | | Expr2031737 |
| | Drives_construct | WBCnstr00004795 |
| | | WBCnstr00036197 |
| | Construct_product | WBCnstr00036197 |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00030922:glycosylated_protein |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00040420:ALM_PLM_enriched |
| | | WBPaper00040420:FLP_enriched |
| | | WBPaper00044316:HgCl2_20uM_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_downregulated |
| | | WBPaper00053664:ins-11(tm1053)_downregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:PLM |
| | | WBPaper00061340:Z1_Z4 |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:mtd-1-mec-18 |
| | | WBPaper00061651:ALM_enriched |
| | | WBPaper00061651:AVM_enriched |
| | | WBPaper00061651:OLQ_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_protein |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065623:67 |
| | | WBPaper00065623:75 |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_2 |
| | | WBPaper00065841:6_3 |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:14_1 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:20_0 |
| | | WBPaper00065841:20_1 |
| | | WBPaper00065841:20_2 |
| | | WBPaper00065841:36_0 |
| | | WBPaper00065841:36_2 |
| | | WBPaper00065841:44_0 |
| | | WBPaper00065841:51_0 |
| | | WBPaper00065841:54_0 |
| | | WBPaper00065841:70_0 |
| | | WBPaper00065841:70_1 |
| | | WBPaper00065841:72_0 |
| | | WBPaper00065841:80_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:126_0 |
| | | WBPaper00065841:128_0 |
| | | WBPaper00065841:133_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4489_group_14 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00032948:StarveUp1 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | Interaction (29) |
| Map_info | Map | V | Position | 2.2108 | Error | 0.000399 |
| | Well_ordered |
| | Positive | Inside_rearr | eDf1 |
| | | Positive_clone | C50H2 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Negative_clone | F15H4 |
| | Mapping_data | 2_point | 133 |
| | | Multi_point | 284 |
| | | | 3103 |
| | | | 3104 |
| | | | 4628 |
| | | Pos_neg_data | 495 |
| | | | 1747 |
| | | | 1751 |
| | | | 3124 |
| | | | 3125 |
| | | | 3126 |
| | | | 3127 |
| Reference (49) |
| Method | Gene |
