| WBGene00003111 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | Y71G12B |
| Identity | Version | 1 |
| | Name | CGC_name | mab-20 | Person_evidence | WBPerson261 |
| | | Sequence_name | Y71G12B.20 |
| | | Molecular_name | Y71G12B.20a |
| | | | Y71G12B.20a.1 |
| | | | CE22926 |
| | | | Y71G12B.20c |
| | | | CE49604 |
| | | | Y71G12B.20d |
| | | | CE49534 |
| | | | Y71G12B.20b |
| | | | Y71G12B.20c.1 |
| | | | Y71G12B.20d.1 |
| | | Other_name | CELE_Y71G12B.20 | Accession_evidence | NDB | BX284601 |
| | | Public_name | mab-20 |
| | DB_info | Database | AceView | gene | 1C118 |
| | | | WormQTL | gene | WBGene00003111 |
| | | | WormFlux | gene | WBGene00003111 |
| | | | NDB | locus_tag | CELE_Y71G12B.20 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00003111|UniProtKB=Q95XP4 |
| | | | | family | PTHR11036 |
| | | | NCBI | gene | 171727 |
| | | | RefSeq | protein | NM_001306515.3 |
| | | | | | NM_001306514.3 |
| | | | | | NR_165326.1 |
| | | | | | NM_058474.5 |
| | | | SwissProt | UniProtAcc | Q95XP4 |
| | | | UniProt_GCRP | UniProtAcc | Q95XP4 |
| | | | RNAcentral | URSid | URS0001981393 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mab |
| | Allele (183) |
| | Legacy_information | [C.elegansII] bx24 : displacements and fusions in rays 1,2,3,4,8,9; R1,2,4 probably transformed to R3. Variable bulges in posterior body region. OA1: bx61ts (weaker). [Baird et al. 1991; Chow and Emmons 1994; EM] |
| | Strain | WBStrain00029150 |
| | | WBStrain00007175 |
| | | WBStrain00007155 |
| | | WBStrain00037940 |
| | RNASeq_FPKM (74) |
| | GO_annotation (30) |
| | Ortholog (40) |
| | Paralog | WBGene00004889 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004890 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00009094 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | mab-20 encodes the C. elegans Semaphorin-2A ortholog; during development, mab-20 activity is required for proper epidermal morphogenesis and axon guidance; specifically, MAB-20, which functions to prevent ectopic, adhesive cell contacts, is required for ventral enclosure during embryogenesis, normal body morphology, and proper formation of sensory rays in the male tail; co-immunoprecipitation experiments demonstrate that MAB-20 interacts with the PLX-2 receptor and that this interaction is strengthened by LAD-2 which can interact with both proteins independently; a MAB-20::GFP reporter, which localizes to the cell surface, is expressed ubiquitously in embryos beginning at morphogenesis; in larvae and adults, MAB-20::GFP is seen in dividing seam cells, neurons, vulval cells, the distal tip cell in hermaphrodites and in males, is additionally seen in the linker cell, cells in the posterior ganglia, and the 9 R(n) ray precursor cells. | Paper_evidence | WBPaper00003939 |
| | | | | | WBPaper00031430 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Apr 2008 00:00:00 |
| | | Automated_description | Enables semaphorin receptor binding activity. Involved in several processes, including anatomical structure morphogenesis; axonal fasciculation; and regulation of locomotion. Located in cell surface. Expressed in several structures, including linker cell; ray neurons; ray precursor cell; somatic nervous system; and vulval cell. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is an ortholog of human SEMA3B (semaphorin 3B) and SEMA3C (semaphorin 3C). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10725) |
| Molecular_info | Corresponding_CDS | Y71G12B.20a |
| | | Y71G12B.20c |
| | | Y71G12B.20d |
| | Corresponding_CDS_history | Y71G12B.20b:wp272 |
| | Corresponding_transcript | Y71G12B.20b |
| | | Y71G12B.20a.1 |
| | | Y71G12B.20c.1 |
| | | Y71G12B.20d.1 |
| | Other_sequence (21) |
| | Associated_feature | WBsf648943 |
| | | WBsf648944 |
| | | WBsf663922 |
| | | WBsf663923 |
| | | WBsf218980 |
| | | WBsf218981 |
| | | WBsf218982 |
| | | WBsf218983 |
| Experimental_info | RNAi_result | WBRNAi00065918 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00058207 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00000882 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1034 |
| | | Expr1027836 |
| | | Expr1031470 |
| | | Expr1161623 |
| | | Expr2013323 |
| | | Expr2031555 |
| | Drives_construct | WBCnstr00000466 |
| | | WBCnstr00010042 |
| | | WBCnstr00036225 |
| | Construct_product | WBCnstr00000466 |
| | | WBCnstr00021009 |
| | | WBCnstr00036225 |
| | Microarray_results (24) |
| | Expression_cluster | WBPaper00030922:glycosylated_protein |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033208:STI-1_interacting |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F1_morc-1(tm6048)_downregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051305:vit-2(ac3)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055386:eat-2(ad465)_downregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056218:daf-16(mu86)_upregulated_Day7 |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060764:swsn-1(os22ts)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060951:mrpl-2(osa3)_downregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:AIN_parent |
| | | WBPaper00061340:ASK_parent |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AVH_parent |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061340:Neuroblast_ADE_ADA |
| | | WBPaper00061340:Neuroblast_AVG_RIR |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061340:Neuroblast_PVC_LUA |
| | | WBPaper00061340:Neuroblast_URX_CEPDx |
| | | WBPaper00061340:OLL_parent |
| | | WBPaper00061340:Parent_of_PVP_and_rect_V |
| | | WBPaper00061340:PLM_ALN_grandparent |
| | | WBPaper00061340:PLM_ALN_great_grandparent |
| | | WBPaper00061340:PVR |
| | | WBPaper00061340:RIA_parent |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061340:URA_parent |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:tbc-10-zfp-3_11365 |
| | | WBPaper00061651:CAN_enriched |
| | | WBPaper00061651:SIA_enriched |
| | | WBPaper00061651:SIB_enriched |
| | | WBPaper00061651:SMD_enriched |
| | | WBPaper00061651:VC_4_5_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_protein |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_transcript |
| | | WBPaper00062456:doxycycline_downregulated_N2_transcript |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066093:E.coli-purE_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_4 |
| | | cgc4489_group_5 |
| | | WBPaper00030985:Erwinia_carotovora_downregulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | Interaction (52) |
| | WBProcess | WBbiopr:00000025 |
| Map_info | Map | I | Position | -13.6256 | Error | 0.025952 |
| | Well_ordered |
| | Positive | Positive_clone | Y71G12A_205 |
| | | | Y71G12B | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 4740 |
| | | | 5224 |
| | | Multi_point | 1678 |
| | | | 3902 |
| | | | 3903 |
| | | Pos_neg_data | 5719 |
| | | | 5720 |
| | | | 5721 |
| | | | 8492 |
| | | | 8493 |
| Reference (56) |
| Remark | Sequence connection from [Roy PJ. Culotti JG] |
| | Y71G12A_205.g amended to Y71G12B.20 [sdm 010712] |
| Method | Gene |
