WormBase Tree Display for Gene: WBGene00003102
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| WBGene00003102 | SMap | S_parent | Sequence | C08C3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mab-5 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C08C3.3 | ||||||||
| Molecular_name | C08C3.3 | ||||||||
| C08C3.3.1 | |||||||||
| CE25765 | |||||||||
| Other_name | lin-21 | ||||||||
| CELE_C08C3.3 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | mab-5 | ||||||||
| DB_info | Database | AceView | gene | 3I868 | |||||
| WormQTL | gene | WBGene00003102 | |||||||
| SignaLink | protein | WBGene00003102 | |||||||
| WormFlux | gene | WBGene00003102 | |||||||
| NDB | locus_tag | CELE_C08C3.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003102|UniProtKB=P10038 | |||||||
| family | PTHR45771 | ||||||||
| NCBI | gene | 176091 | |||||||
| RefSeq | protein | NM_066294.8 | |||||||
| SwissProt | UniProtAcc | P10038 | |||||||
| UniProt_GCRP | UniProtAcc | P10038 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mab | ||||||||
| Reference_allele | WBVar00143853 | ||||||||
| Allele (101) | |||||||||
| Legacy_information | e1239 : postembryonic lineages and migrations in pre-anal region generally abnormal; adult male tail morphology thin grossly abnormal V rays missing T rays present sex mesoblast lineages etc. abnormal. ES3 (male) ME0. Hermaphrodite gross phenotype is wildtype but V divisions Q migrations coelomocytes all abnormal. ES1 (hermaphrodite). Similar mutant phenotypes in e1239/Df. NA4 (e1936 e2011 e2088 (all resemble e1239)). | ||||||||
| See also e1239, e1936, e2011, e2088 | |||||||||
| [C.elegansII] e1239 : postembryonic lineages and migrations in pre-anal region generally abnormal; adult male tail morphology thin, grossly abnormal; V rays missing, T rays present; sex mesoblast lineages etc. abnormal. ES3 (male) ME0. Hermaphrodite gross phenotype WT but V divisions, Q migrations coelomocytes all abnormal. ES1 (hermaphrodite). Mosaic analysis indicates cell autonomous. Similar mutant phenotypes in e1239/Df. OA>8: e1936, e2011 (Q24och), e2088 (all resemble e1239) etc. Also bx54sd (dominant missense, ray fusion phenotype) See also lin-21. Cloned: HOM-C member, encodes homeoprotein related to Antennapedia. Extensive molecular analysis. [Kenyon 1986; Cowing and Kenyon 1992; CF] | |||||||||
| e1751sd : slightly uncoordinated abnormal migration of Q neuroblasts both QL and QR migrate posteriorly. NA1. | |||||||||
| See also e1751 | |||||||||
| Strain (21) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (50) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | mab-5 encodes a homeodomain transcription factor related to the Antennapedia, Ultrabithorax, and abdominal-A family of homeodomain proteins; during postembryonic development, mab-5 is required cell autonomously for specification of posterior cell fates, including hypodermal and neuronal fates, programmed cell deaths, cell proliferation and migration, and fate specification of the male-specific copulatory muscles and sensory rays; in addition, ectopic expression of mab-5 is sufficient to alter cell fates, such as direction of migration or sensory ray identity; in regions of the body where mab-5 expression overlaps with that of lin-39, another C. elegans HOM-C gene, the two genes appear to either compensate for one another's activity or act combinatorially to promote cell fates distinct from those where either gene is expressed alone; a mab-5:lacZ reporter fusion is expressed in cells in the posterior body region from the mid-gastrulation stage of embryogenesis through larval and adult stages; further, antibody staining reveals that MAB-5 expression in the V5 lineage is dynamic, switching on and off several times, while expression in V6 is continuous throughout most of the L1-L3 larval stages; early MAB-5 expression is V6 is dependent upon wild-type activity of pal-1, which encodes the C. elegans Caudal ortholog. | Paper_evidence | WBPaper00000913 | |||||
| WBPaper00001492 | |||||||||
| WBPaper00001767 | |||||||||
| WBPaper00001815 | |||||||||
| WBPaper00002453 | |||||||||
| WBPaper00002582 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 May 2006 00:00:00 | ||||||||
| Automated_description | Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including neuroblast migration; positive regulation of mesodermal cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including body ganglion; body wall musculature; male-specific anatomical entity; neurons; and vulval cell. Is an ortholog of human HOXB8 (homeobox B8) and HOXC8 (homeobox C8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C08C3.3 | |||||||
| Corresponding_transcript | C08C3.3.1 | ||||||||
| Other_sequence (21) | |||||||||
| Associated_feature (20) | |||||||||
| Gene_product_binds (2103) | |||||||||
| Transcription_factor | WBTranscriptionFactor000013 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00115791 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00083967 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101810 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040081 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00083969 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091435 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010438 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066004 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005695 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101792 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00083968 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101811 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086118 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101791 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (21) | |||||||||
| Drives_construct (27) | |||||||||
| Construct_product (18) | |||||||||
| Regulate_expr_cluster | WBPaper00037946:MAB-5_interacting | ||||||||
| Antibody | WBAntibody00000075 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (148) | |||||||||
| Interaction (395) | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| WBbiopr:00000082 | |||||||||
| Map_info | Map | III | Position | -0.594594 | Error | 0.002643 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C08C3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZC102 | |||||||||
| Mapping_data | 2_point | 349 | |||||||
| 673 | |||||||||
| Multi_point | 220 | ||||||||
| 1110 | |||||||||
| 1494 | |||||||||
| 1502 | |||||||||
| 1624 | |||||||||
| 588 | |||||||||
| 589 | |||||||||
| 590 | |||||||||
| 5266 | |||||||||
| Pos_neg_data | 359 | ||||||||
| 1609 | |||||||||
| 1610 | |||||||||
| Landmark_gene | |||||||||
| Reference (432) | |||||||||
| Picture | WBPicture0000013083 | ||||||||
| Remark | [e1751 is in fact a tandem duplication of 100 kb that includes mab-5, and therefore has mab-5(gf) properties [JAH][021015 ck1] | ||||||||
| Method | Gene |
