WormBase Tree Display for Gene: WBGene00003056

WBGene00003056 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: lon-2 Person_evidence: WBPerson261
      Sequence_name: C39E6.1
      Molecular_name: C39E6.1
        C39E6.1.1
        CE35426
      Other_name: CELE_C39E6.1 Accession_evidence: NDB BX284606
      Public_name: lon-2
    DB_info: Database: AceView gene XF356
        WormQTL gene WBGene00003056
        WormFlux gene WBGene00003056
        NDB locus_tag CELE_C39E6.1
        Panther gene CAEEL|WormBase=WBGene00003056|UniProtKB=Q18530
          family PTHR10822
        NCBI gene 180750
        RefSeq protein NM_076411.8
        TREEFAM TREEFAM_ID TF353541
        TrEMBL UniProtAcc Q18530
        UniProt_GCRP UniProtAcc Q18530
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lon
    Reference_allele: WBVar00143398
    Allele (213)
    Legacy_information: e678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678).
      [C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974]
    Strain (224)
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (25)
    Structured_description: Concise_description: lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface. Paper_evidence: WBPaper00029002
          Curator_confirmed: WBPerson1843
          Date_last_updated: 24 Jan 2007 00:00:00
      Automated_description: Enables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C39E6.1
    Corresponding_CDS_history: C39E6.1:wp107
    Corresponding_transcript: C39E6.1.1
    Other_sequence: CRC07010_1
      CR09868
      CGC00490_1
      CBC13859_1
      CJC03031_1
      CRC04307_1
    Associated_feature (15)
  Experimental_info: RNAi_result (23)
    Expr_pattern: Expr4651
      Expr4652
      Expr12191
      Expr1011265
      Expr1031435
      Expr1146202
      Expr2013244
      Expr2031475
    Drives_construct: WBCnstr00012150
      WBCnstr00012151
      WBCnstr00021097
      WBCnstr00021479
      WBCnstr00036259
    Construct_product: WBCnstr00012151
      WBCnstr00021471
      WBCnstr00021474
      WBCnstr00021479
      WBCnstr00036259
    Microarray_results (21)
    Expression_cluster (142)
    Interaction (24)
  Map_info: Map: X Position: -6.74013 Error: 0.007834
    Well_ordered
    Positive: Inside_rearr: mnDp30
        yDp4
      Positive_clone: C39E6 Inferred_automatically: From sequence, transcript, pseudogene data
        F43C9
    Negative: Outside_rearr: mcDf2
    Mapping_data: 2_point (57)
      Multi_point (150)
      Pos_neg_data (31)
    Landmark_gene
  Reference: WBPaper00000031
    WBPaper00000120
    WBPaper00000168
    WBPaper00000178
    WBPaper00000538
    WBPaper00000608
    WBPaper00001328
    WBPaper00001454
    WBPaper00001477
    WBPaper00001558
    WBPaper00001567
    WBPaper00001649
    WBPaper00001709
    WBPaper00001721
    WBPaper00001722
    WBPaper00001730
    WBPaper00001738
    WBPaper00001852
    WBPaper00001906
    WBPaper00002047
    WBPaper00003197
    WBPaper00003454
    WBPaper00003720
    WBPaper00003859
    WBPaper00005732
    WBPaper00005747
    WBPaper00005774
    WBPaper00005811
    WBPaper00005927
    WBPaper00006103
    WBPaper00006384
    WBPaper00010175
    WBPaper00010521
    WBPaper00010648
    WBPaper00010897
    WBPaper00010991
    WBPaper00011197
    WBPaper00011213
    WBPaper00011725
    WBPaper00011841
    WBPaper00012551
    WBPaper00013698
    WBPaper00013736
    WBPaper00013777
    WBPaper00013889
    WBPaper00013986
    WBPaper00014027
    WBPaper00014080
    WBPaper00014086
    WBPaper00014166
    WBPaper00014349
    WBPaper00014836
    WBPaper00014842
    WBPaper00015055
    WBPaper00015107
    WBPaper00015253
    WBPaper00015421
    WBPaper00015425
    WBPaper00015483
    WBPaper00015518
    WBPaper00015573
    WBPaper00015627
    WBPaper00015717
    WBPaper00015764
    WBPaper00015994
    WBPaper00016014
    WBPaper00016027
    WBPaper00016040
    WBPaper00016075
    WBPaper00016119
    WBPaper00016180
    WBPaper00016194
    WBPaper00016248
    WBPaper00016418
    WBPaper00016491
    WBPaper00016538
    WBPaper00017219
    WBPaper00017704
    WBPaper00018212
    WBPaper00018447
    WBPaper00018514
    WBPaper00018515
    WBPaper00018518
    WBPaper00018520
    WBPaper00019664
    WBPaper00019671
    WBPaper00021010
    WBPaper00021083
    WBPaper00022114
    WBPaper00022232
    WBPaper00022233
    WBPaper00022676
    WBPaper00022782
    WBPaper00022944
    WBPaper00023410
    WBPaper00023637
    WBPaper00023692
    WBPaper00023755
    WBPaper00024732
    WBPaper00025836
    WBPaper00025994
    WBPaper00026015
    WBPaper00026103
    WBPaper00027231
    WBPaper00027314
    WBPaper00027661
    WBPaper00027669
    WBPaper00027702
    WBPaper00028036
    WBPaper00028462
    WBPaper00029002
    WBPaper00029020
    WBPaper00029198
    WBPaper00030871
    WBPaper00031028
    WBPaper00031142
    WBPaper00032029
    WBPaper00032413
    WBPaper00032446
    WBPaper00032891
    WBPaper00034044
    WBPaper00035040
    WBPaper00035539
    WBPaper00035589
    WBPaper00036295
    WBPaper00038625
    WBPaper00039446
    WBPaper00039736
    WBPaper00040382
    WBPaper00041479
    WBPaper00043167
    WBPaper00043586
    WBPaper00043908
    WBPaper00044242
    WBPaper00045208
    WBPaper00045532
    WBPaper00045569
    WBPaper00046364
    WBPaper00046792
    WBPaper00046993
    WBPaper00048212
    WBPaper00050783
    WBPaper00051317
    WBPaper00052022
    WBPaper00053362
    WBPaper00055256
    WBPaper00055882
    WBPaper00057976
    WBPaper00060487
    WBPaper00061031
    WBPaper00061119
    WBPaper00062532
    WBPaper00065849
    WBPaper00065859
    WBPaper00066003
  Remark: sequence wsa incorrectly given as F43C9.3
  Method: Gene