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WormBase Tree Display for Gene: WBGene00003056

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Name Class

WBGene00003056SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namelon-2Person_evidenceWBPerson261
Sequence_nameC39E6.1
Molecular_nameC39E6.1
WP:CE35426
CE35426
Other_nameCELE_C39E6.1Accession_evidenceNDBBX284606
Public_namelon-2
DB_infoDatabaseAceViewgeneXF356
WormQTLgeneWBGene00003056
WormFluxgeneWBGene00003056
NDBlocus_tagCELE_C39E6.1
NCBIgene180750
RefSeqmRNANM_076411.5
proteinNP_508812.3
TREEFAMTREEFAM_IDTF353541
TrEMBLUniProtAccQ18530
UniProt_GCRPUniProtAccQ18530
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlon
Reference_alleleWBVar00143398
Allele (213)
Legacy_informatione678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678).
[C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974]
Strain (216)
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (11)
Structured_descriptionProvisional_descriptionlon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface.Paper_evidenceWBPaper00029002
Curator_confirmedWBPerson1843
Date_last_updated24 Jan 2007 00:00:00
Concise_descriptionlon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface.
Automated_descriptionlon-2 is involved in negative regulation of growth, negative regulation of transforming growth factor beta receptor signaling pathway and regulation of cell migration; lon-2 is predicted to have heparan sulfate proteoglycan binding activity, based on protein domain information; lon-2 is expressed in the hypodermis and the intestine; lon-2 is localized to the cell surface.Paper_evidence (12)
Accession_evidenceINTERPROIPR001863
Curator_confirmedWBPerson17622
WBPerson324
Inferred_automaticallyThis description was generated automatically by a Textpresso script based on homology/orthology data, Gene Ontology (GO) annotations and tissue expression data from the WS264 version of WormBase.
Date_last_updated08 Mar 2018 00:00:00
Molecular_infoCorresponding_CDSC39E6.1
Corresponding_CDS_historyC39E6.1:wp107
Corresponding_transcriptC39E6.1
Other_sequenceCRC07010_1
CR09868
CGC00490_1
CBC13859_1
CJC03031_1
CRC04307_1
Associated_feature (15)
Experimental_infoRNAi_result (22)
Expr_patternExpr4651
Expr4652
Expr12191
Expr1011265
Expr1031435
Expr1146202
Drives_constructWBCnstr00012150
WBCnstr00012151
WBCnstr00021097
WBCnstr00021479
WBCnstr00036259
Construct_productWBCnstr00012151
WBCnstr00021471
WBCnstr00021474
WBCnstr00021479
WBCnstr00036259
Microarray_results (20)
Expression_cluster (70)
Interaction (22)
Map_infoMapXPosition-6.74013Error0.007834
Well_ordered
PositiveInside_rearrmnDp30
yDp4
Positive_cloneC39E6
F43C9
NegativeOutside_rearrmcDf2
Mapping_data2_point (57)
Multi_point (150)
Pos_neg_data (31)
Landmark_gene
Reference (142)
Remarksequence wsa incorrectly given as F43C9.3
MethodGene