lmp-1 encodes a protein with similarity to vertebrate lysosome-associated membrane proteins CD68, and appears to be the only protein in C. elegans that has a GYXX (phi) vertebrate lysosomal targeting sequence at its carboxy terminus; LMP-1 is widely expressed in the early embryo, with later expression seen in the intestine, coelomocytes, and neurons; LMP-1 localizes to lysosomes and is recruited to phagosomes upon lysosomal fusion.
Predicted to be involved in establishment of protein localization to organelle. Located in cytoplasmic vesicle and lysosomal membrane. Expressed in coelomocyte; germ line; and pharynx. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Is an ortholog of human LAMP2 (lysosomal associated membrane protein 2).
Sequence connection from [Fire AZ, Kostich M, Fambrough DM]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.