WormBase Tree Display for Gene: WBGene00003048
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| WBGene00003048 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lit-1 | Person_evidence | WBPerson561 | |||||
| Sequence_name | W06F12.1 | ||||||||
| Molecular_name (17) | |||||||||
| Other_name | CELE_W06F12.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | lit-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lit | ||||||||
| Allele (321) | |||||||||
| Legacy_information | [Kaletta T] t1512 is ts, strict Mel at 20C, with lack of intestinal cells and excess pharyngeal cells, multiple posterior to anterior transformations in embryonic cell lineage, zygotic lethal/sterile/Egl at 25C, viable at 15C, t1534 is weaker allele, nonconditional, non-strict Mel at 20C. | ||||||||
| [Bowerman BA] temperature sensitive embryonic lethal mutant, permissive = 15 C, restrictive = 25 C | |||||||||
| Complementation_data | [Bowerman BA] fails to complement lit-1(t1512) | ||||||||
| Strain | WBStrain00035938 | ||||||||
| WBStrain00040429 | |||||||||
| WBStrain00007293 | |||||||||
| WBStrain00007328 | |||||||||
| WBStrain00007762 | |||||||||
| WBStrain00007769 | |||||||||
| WBStrain00008483 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (74) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | lit-1 encodes a serine threonine protein kinase homolog related to the Drosophila protein Nemo; lit-1 is required for embryonic viability and plays a central role in controlling the asymmetry of cell divisions during embryogenesis; lit-1 acts downstream of mom-2 with respect to polarity defects and mediates larval cell fate decisions that involve POP-1; lit-1 is also required for amphid channel morphogenesis and thus, also for normal morphology of the outer labial sensilla; specifically, lit-1 is required in sheath glia for positively regulating amphid sensory compartment expansion; lit-1 is expressed in most embryonic and larval cells, including the amphid sheath glia. | Paper_evidence | WBPaper00002946 | |||||
| WBPaper00003570 | |||||||||
| WBPaper00003574 | |||||||||
| WBPaper00003656 | |||||||||
| WBPaper00004315 | |||||||||
| WBPaper00005116 | |||||||||
| WBPaper00040113 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 24 Oct 2011 00:00:00 | ||||||||
| Automated_description | Enables beta-catenin binding activity and protein serine/threonine kinase activity. Involved in several processes, including cell fate commitment; polarity specification of proximal/distal axis; and positive regulation of nematode male tail tip morphogenesis. Located in cell cortex and nucleus. Part of serine/threonine protein kinase complex. Expressed in several structures, including hermaphrodite gonad; pharynx; tail hypodermis; and vulva. Is an ortholog of human NLK (nemo like kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | W06F12.1a | |||||||
| W06F12.1b | |||||||||
| W06F12.1c | |||||||||
| W06F12.1d | |||||||||
| W06F12.1e | |||||||||
| Corresponding_CDS_history | W06F12.1a:wp65 | ||||||||
| W06F12.1b:wp65 | |||||||||
| Corresponding_transcript | W06F12.1a.1 | ||||||||
| W06F12.1b.1 | |||||||||
| W06F12.1c.1 | |||||||||
| W06F12.1d.1 | |||||||||
| W06F12.1d.2 | |||||||||
| W06F12.1d.3 | |||||||||
| W06F12.1e.1 | |||||||||
| Other_sequence (18) | |||||||||
| Associated_feature (58) | |||||||||
| Experimental_info | RNAi_result (130) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct (13) | |||||||||
| Construct_product (19) | |||||||||
| Antibody | WBAntibody00002616 | ||||||||
| WBAntibody00002619 | |||||||||
| Microarray_results (48) | |||||||||
| Expression_cluster (153) | |||||||||
| Interaction (483) | |||||||||
| Anatomy_function | WBbtf0423 | ||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info (4) | |||||||||
| Reference (151) | |||||||||
| Picture | WBPicture0000013084 | ||||||||
| Remark | Mapped to ca. 0.3 cM left of bli-5. Data extracted from Kaletta et al. (1997) | ||||||||
| Method | Gene |
