| WBGene00003043 | SMap | S_parent | Sequence | C05B10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | lip-1 | Person_evidence | WBPerson232 |
| | | Sequence_name | C05B10.1 |
| | | Molecular_name | C05B10.1a |
| | | | C05B10.1a.1 |
| | | | CE31151 |
| | | | C05B10.1b |
| | | | CE49310 |
| | | | C05B10.1b.1 |
| | | | C05B10.1c |
| | | Other_name | CELE_C05B10.1 | Accession_evidence | NDB | BX284604 |
| | | Public_name | lip-1 |
| | DB_info | Database (14) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lip |
| | Allele (45) |
| | Strain | WBStrain00000142 |
| | | WBStrain00001321 |
| | | WBStrain00000141 |
| | | WBStrain00000146 |
| | | WBStrain00022639 |
| | | WBStrain00051597 |
| | RNASeq_FPKM (74) |
| | GO_annotation (58) |
| | Ortholog (42) |
| | Paralog | WBGene00006923 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00007302 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00007697 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00009142 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00009207 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00014074 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00015807 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00017428 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00021867 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | lip-1 encodes a mitogen-activated protein (MAP) kinase phosphatase homologous to the vertebrate dual specificity phosphatase MKP-3; during development, LIP-1 negatively regulates MAP kinase activity to control the extent of germline proliferation and oocyte meiotic cell cycle progression; lip-1 activity is also required redundantly with dep-1 to negatively regulate MAPK signaling during vulval induction; in addition, lip-1 is required for normal embryonic development; lip-1 expression begins during embryogenesis and continues through adulthood; expression is seen in most somatic cells and in germ cells of the pachytene region, transition zone and proximal-most region of the mitotic zone; in the pachytene region, LIP-1 is associated with the plasma membrane; in early L3 larvae, LIP-1 expression increases in secondary vulval precursor cells in a lin-12/Notch-dependent manner, suggesting that lip-1 may be a direct downstream target of lin-12-mediated signaling; interaction with the Notch pathway is further demonstrated by chromatin immunoprecipitation experiments showing that, in the germline, the lip-1 promoter region coprecipitates with LAG-3; germline lip-1 mRNA accumulation is negatively regulated by the FBF proteins (FBF-1 and FBF-2) that bind to the lip-1 3'UTR. | Paper_evidence | WBPaper00004542 |
| | | | | | WBPaper00005425 |
| | | | | | WBPaper00025197 |
| | | | | | WBPaper00026961 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 27 Nov 2006 00:00:00 |
| | | Automated_description | Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Involved in several processes, including negative regulation of Ras protein signal transduction; positive regulation of vulval development; and vulval cell fate specification. Located in plasma membrane. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and germ line. Human ortholog(s) of this gene implicated in breast cancer and hypogonadotropic hypogonadism 19 with or without anosmia. Is an ortholog of human DUSP6 (dual specificity phosphatase 6) and DUSP7 (dual specificity phosphatase 7). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0090090 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3072) |
| | | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3072) |
| Molecular_info | Corresponding_CDS | C05B10.1a |
| | | C05B10.1b |
| | Corresponding_transcript | C05B10.1c |
| | | C05B10.1a.1 |
| | | C05B10.1b.1 |
| | Other_sequence (19) |
| | Associated_feature | WBsf660248 |
| | | WBsf718114 |
| | | WBsf996841 |
| | | WBsf996842 |
| | | WBsf996843 |
| | | WBsf1017628 |
| Experimental_info | RNAi_result | WBRNAi00010167 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00087951 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00075905 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00007925 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00087228 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00039684 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (14) |
| | Drives_construct | WBCnstr00000956 |
| | | WBCnstr00000958 |
| | | WBCnstr00002214 |
| | | WBCnstr00005189 |
| | | WBCnstr00005285 |
| | | WBCnstr00005411 |
| | | WBCnstr00008051 |
| | | WBCnstr00008476 |
| | Construct_product | WBCnstr00005241 |
| | | WBCnstr00006272 |
| | Antibody | WBAntibody00000542 |
| | | WBAntibody00000958 |
| | | WBAntibody00001202 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00024245:gst-5-binding_control |
| | | WBPaper00029359_1166 |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1320 |
| | | WBPaper00029359_1326 |
| | | WBPaper00029359_1345 |
| | | WBPaper00029359_1439 |
| | | WBPaper00029359_1458 |
| | | WBPaper00029359_1546 |
| | | WBPaper00029359_1549 |
| | | WBPaper00029359_1557 |
| | | WBPaper00029359_1599 |
| | | WBPaper00029359_1618 |
| | | WBPaper00032425:up_in_zfp-1 |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00044786:emr-1(gk119)_downregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049736:15deg-then-25deg(12hr)_upregulated_N2 |
| | | WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F1_morc-1(tm6048)_downregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056284:ints-6(t1903)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057154:HeatShock_upregulated_miRNA-target |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058886:anp-1(ok608)_downregulated |
| | | WBPaper00058942:henn-1(pk2295)_downregulated |
| | | WBPaper00059440:GLP-1_activated |
| | | WBPaper00059440:LAG-1_activated_48hr-auxin |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:Neuroblast_PVC_LUA |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061527:T23B5.3_15993-C17D12.1 |
| | | WBPaper00061902:camt-1(ok515)_regulated_AFD |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_upregulated |
| | | WBPaper00062497:xpf-1(tm2842)_downregulated |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00062587:lsl-1(ljm1)_downregulated |
| | | WBPaper00062587:lsl-1(tm4769)_downregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_downregulated |
| | | WBPaper00064315:mes-3(bn199)_downregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00065086:N2_N.ferruginous_regulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:44_1 |
| | | WBPaper00065841:105_0 |
| | | WBPaper00065841:118_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066085:sin-3(syb2172)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_4 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_downregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (78) |
| | Anatomy_function | WBbtf0120 |
| Map_info | Map | IV | Position | 3.24356 | Error | 0.000851 |
| | Positive | Positive_clone | C05B10 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4478 |
| | | | 4737 |
| | | | 5424 |
| | Pseudo_map_position |
| Reference (69) |
| Remark | email 41 from wen chen. |
| | Sequence connection from [Berset T, Hajnal AF] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
