WormBase Tree Display for Gene: WBGene00003012
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| WBGene00003012 | SMap | S_parent | Sequence | F18A1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-26 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F18A1.2 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_F18A1.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | lin-26 | ||||||||
| DB_info | Database | AceView | gene | 2H973 | |||||
| WormQTL | gene | WBGene00003012 | |||||||
| SignaLink | protein | WBGene00003012 | |||||||
| WormFlux | gene | WBGene00003012 | |||||||
| NDB | locus_tag | CELE_F18A1.2 | |||||||
| NCBI | gene | 3565051 | |||||||
| RefSeq | protein | NM_001306657.3 | |||||||
| NM_001306658.3 | |||||||||
| NM_001356872.3 | |||||||||
| NM_001026921.6 | |||||||||
| SwissProt | UniProtAcc | Q27355 | |||||||
| UniProt_GCRP | UniProtAcc | Q27355 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00089290 | ||||||||
| Allele (43) | |||||||||
| Legacy_information | n156 : adult hermaphrodites vulvaless ( > 99%) slightly small and fat HME1. ES2. Males very small scrawny rounded tail ME0. n156/Df is larval lethal. NA1. | ||||||||
| [Labouesse M] n156 animals were injected together with rol-6(su1006) at 80 ng/microl and F2 rollers were picked and ability to lay eggs was scored as rescue (n156 animals are vulvaless and hence bag). The cosmids were injected at a concentration of 10 ng/microlitre or less. Further subcloning showed a 9 kb fragment from K06E5 to be sufficient to rescue n156. | |||||||||
| See also n156 | |||||||||
| [Labouesse M] mc2 and mc4 are embryonic lethals. mc2 mild loss-of-function, mc4 is strong. | |||||||||
| [Sookhareea S & Labouesse M] pk38/mc15 null mutation similar phenotype to mc1 & mc4. emb-lethal plus degeneration of hyp cells and glial cells. | |||||||||
| [C.elegansII] n156 : adult hermaphrodites vulvaless ( >99%), slightly small and fat; HME1. General hypodermal and support cell defects,hypodermal cells die or neuralize. 2% sterile.ES2. Males very small scrawny rounded tail; ME0. n156/Df is larval lethal. OA4: mc1, mc2 (both embryonic lethal),pk38tci, mc15 (deletion derivative). Cloned: encodes predicted zinc finger transcription factor. Antibody stains hypodermis,support cells, uterine cells. [Labouesse et al. 1994; MT; ML] | |||||||||
| Complementation_data | C18C9 (2 F2 rescued Rol/ 3 F2 lines); K06E5 (6 F2 rescuedRol lines / 6 F2 lines); C24G10 (0 F2 rescued Rol/ 2 lines and 0 F2 recued lines / 14 F2 Rol lines when injected in combination with C09G7); C36F4 (0 F2 rescued Rol lines/ 1 F2 Rol line); C18D9 ( 0 F2 rescued Rol line/ 1 F2 Rol) C43A1 (O rescued/ 3 F2 Rol lines); F31B8 (4 F2 recued Rol lines/ 6 F2 Rol lines) | ||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Contained_in_operon | CEOP2300 | ||||||||
| Ortholog (20) | |||||||||
| Paralog | WBGene00003044 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00003045 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003046 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010264 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00013350 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00018740 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00018833 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00304808 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lin-26 encodes a zinc-finger protein that shares a unique C2H2 motif together with LIR-1, LIR-2, and LIR-3; during development, lin-26 activity is required for proper differentiation of non-neuronal ectodermal cells and the somatic gonad epithelium; LIN-26 is expressed in many different cell types including the rectal rep, somatic gonad, glial, and hypodermal cells; ectopic LIN-26 expression during embryogenesis induces epithelial-like cell fates suggesting that LIN-26 is sufficient for epithelial differentiation. | Paper_evidence | WBPaper00002025 | |||||
| WBPaper00002551 | |||||||||
| WBPaper00003169 | |||||||||
| WBPaper00003422 | |||||||||
| WBPaper00004780 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Dec 2006 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; tissue development; and vulval development. Located in nucleus. Expressed in several structures, including Z2; epithelial cell; germ line; gonad; and somatic gonad precursor. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F18A1.2a | |||||||
| F18A1.2b | |||||||||
| F18A1.2c | |||||||||
| F18A1.2d | |||||||||
| Corresponding_CDS_history | F18A1.2a:wp127 | ||||||||
| F18A1.2b:wp127 | |||||||||
| Corresponding_transcript | F18A1.2a.1 | ||||||||
| F18A1.2b.1 | |||||||||
| F18A1.2c.1 | |||||||||
| F18A1.2d.1 | |||||||||
| Other_sequence | Dviv_isotig25737 | ||||||||
| CR09194 | |||||||||
| CR12344 | |||||||||
| Acan_isotig04726 | |||||||||
| CR01875 | |||||||||
| CR03487 | |||||||||
| CJC08342_1 | |||||||||
| Oden_isotig20186 | |||||||||
| CRC00413_1 | |||||||||
| Associated_feature | WBsf644403 | ||||||||
| WBsf657865 | |||||||||
| WBsf657866 | |||||||||
| WBsf978570 | |||||||||
| WBsf988536 | |||||||||
| WBsf988537 | |||||||||
| WBsf1012586 | |||||||||
| WBsf221629 | |||||||||
| WBsf221630 | |||||||||
| WBsf221631 | |||||||||
| Transcription_factor | WBTranscriptionFactor000314 | ||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct (34) | |||||||||
| Construct_product | WBCnstr00000938 | ||||||||
| WBCnstr00000939 | |||||||||
| WBCnstr00000940 | |||||||||
| WBCnstr00036285 | |||||||||
| Antibody | WBAntibody00000122 | ||||||||
| WBAntibody00001543 | |||||||||
| Microarray_results (40) | |||||||||
| Expression_cluster (146) | |||||||||
| SAGE_tag (19) | |||||||||
| Interaction (140) | |||||||||
| Map_info | Map | II | Position | 0.516432 | |||||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mcDf1 | Person_evidence | WBPerson351 | |||||
| mnDf88 | Person_evidence | WBPerson351 | |||||||
| mnDf105 | Person_evidence | WBPerson351 | |||||||
| Positive_clone | C18C9 | ||||||||
| F18A1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| F31B8 | |||||||||
| K06E5 | |||||||||
| Negative | Outside_rearr | mcDf3 | |||||||
| Negative_clone | C01D8 | ||||||||
| C09G7 | |||||||||
| C18D9 | |||||||||
| C24G10 | |||||||||
| C36F4 | |||||||||
| F43A1 | |||||||||
| Mapping_data | Multi_point | 706 | |||||||
| 707 | |||||||||
| 708 | |||||||||
| 709 | |||||||||
| 710 | |||||||||
| 711 | |||||||||
| 4479 | |||||||||
| 4530 | |||||||||
| 5721 | |||||||||
| Pos_neg_data | 6903 | ||||||||
| 6904 | |||||||||
| 6905 | |||||||||
| 6906 | |||||||||
| 6907 | |||||||||
| 6908 | |||||||||
| 6909 | |||||||||
| 8955 | |||||||||
| 10239 | |||||||||
| Landmark_gene | |||||||||
| Reference (137) | |||||||||
| Method | Gene |
