WormBase Tree Display for Gene: WBGene00003011
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| WBGene00003011 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lin-25 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F56H9.5 | ||||||||
| Molecular_name | F56H9.5 | ||||||||
| F56H9.5.1 | |||||||||
| CE05975 | |||||||||
| Other_name | mdt-24 | Person_evidence | WBPerson3947 | ||||||
| CELE_F56H9.5 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | lin-25 | ||||||||
| DB_info | Database | AceView | gene | 5N137 | |||||
| WormQTL | gene | WBGene00003011 | |||||||
| SignaLink | protein | WBGene00003011 | |||||||
| WormFlux | gene | WBGene00003011 | |||||||
| NDB | locus_tag | CELE_F56H9.5 | |||||||
| NCBI | gene | 179732 | |||||||
| RefSeq | protein | NM_073761.8 | |||||||
| SwissProt | UniProtAcc | Q10573 | |||||||
| TREEFAM | TREEFAM_ID | TF316646 | |||||||
| UniProt_GCRP | UniProtAcc | Q10573 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 12 Nov 2014 12:54:52 | WBPerson2970 | Name_change | Other_name | mdt-24 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00144008 | ||||||||
| Allele (91) | |||||||||
| Legacy_information | e1446 : adult hermaphrodite vulvaless 11% sterile. ES2. HME1. Males morphologically wildtype ME0. NA2 (n545ts (at 25x resembles e1446 at 15x 8% Vul)). | ||||||||
| [Tuck SP] lin for lineage abnormal. Hermaphrodites are Egl | |||||||||
| See also e1446, n545, n1062, n1063 | |||||||||
| [C.elegansII] e1446 : adult hermaphrodite vulvaless,11% sterile. VPC all 3ary except P6.p. Suppresses lin-1, let-60(gf), not lin-12(gf).ES2. HME1. Males morphologically wildtype ME0. OA9: n545ts (at 25C resembles e1446, at 15C 8% Vul), n1063, ku78, ar90 (probable null, resembles e1446), etc. Cloned: encodes predicted 1139 aa novel protein. [Tuck and Greenwald 1995; GS] | |||||||||
| Strain | WBStrain00026528 | ||||||||
| WBStrain00026804 | |||||||||
| WBStrain00026902 | |||||||||
| WBStrain00027100 | |||||||||
| WBStrain00005521 | |||||||||
| WBStrain00008013 | |||||||||
| WBStrain00008017 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (27) | |||||||||
| Structured_description | Concise_description | lin-25 encodes a divergent homolog of the TRAP100/Med24 subunit of the Mediator complex; during development, lin-25 functions downstream of let-60 ras to regulate fate specification and differentiation of a number of cell types such as the vulval precursor cells; targets of LIN-25 activity include the lin-39 Hox gene, whose transcriptional upregulation during vulval cell fate specification is dependent upon lin-25; LIN-25 is expressed in vulval precursor cells, hypodermal seam cells, and cells in the somatic gonad; LIN-25 is detected in nuclei, but also seen in the cytoplasm. | Paper_evidence | WBPaper00003330 | |||||
| WBPaper00004407 | |||||||||
| WBPaper00027035 | |||||||||
| WBPaper00035311 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 May 2007 00:00:00 | ||||||||
| Automated_description | Involved in defense response to Gram-positive bacterium and vulval development. Acts upstream of or within with a positive effect on cell fate specification. Located in cytoplasm and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; hermaphrodite distal tip cell; and vulval cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F56H9.5 | |||||||
| Corresponding_transcript | F56H9.5.1 | ||||||||
| Other_sequence | CJC16777 | ||||||||
| Associated_feature | WBsf647392 | ||||||||
| WBsf661921 | |||||||||
| WBsf1001624 | |||||||||
| WBsf1020604 | |||||||||
| WBsf232679 | |||||||||
| WBsf232680 | |||||||||
| WBsf232681 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00067753 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00095285 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048794 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067528 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015856 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1293 | ||||||||
| Expr1023216 | |||||||||
| Expr1031405 | |||||||||
| Expr1152543 | |||||||||
| Expr2013169 | |||||||||
| Expr2031401 | |||||||||
| Drives_construct | WBCnstr00004617 | ||||||||
| WBCnstr00004618 | |||||||||
| WBCnstr00036286 | |||||||||
| Construct_product | WBCnstr00004617 | ||||||||
| WBCnstr00004618 | |||||||||
| WBCnstr00036286 | |||||||||
| Antibody | WBAntibody00000201 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction | WBInteraction000000695 | ||||||||
| WBInteraction000000757 | |||||||||
| WBInteraction000000758 | |||||||||
| WBInteraction000000760 | |||||||||
| WBInteraction000001236 | |||||||||
| WBInteraction000001237 | |||||||||
| WBInteraction000001238 | |||||||||
| WBInteraction000001307 | |||||||||
| WBInteraction000002023 | |||||||||
| WBInteraction000002703 | |||||||||
| WBInteraction000002704 | |||||||||
| WBInteraction000002754 | |||||||||
| WBInteraction000002763 | |||||||||
| WBInteraction000005069 | |||||||||
| WBInteraction000005070 | |||||||||
| WBInteraction000005071 | |||||||||
| WBInteraction000005738 | |||||||||
| WBInteraction000006151 | |||||||||
| WBInteraction000006152 | |||||||||
| WBInteraction000006153 | |||||||||
| WBInteraction000006154 | |||||||||
| WBInteraction000006155 | |||||||||
| WBInteraction000006156 | |||||||||
| WBInteraction000006157 | |||||||||
| WBInteraction000006158 | |||||||||
| WBInteraction000006159 | |||||||||
| WBInteraction000006982 | |||||||||
| WBInteraction000007207 | |||||||||
| WBInteraction000009513 | |||||||||
| WBInteraction000009748 | |||||||||
| WBInteraction000009832 | |||||||||
| WBInteraction000028197 | |||||||||
| WBInteraction000028199 | |||||||||
| WBInteraction000028231 | |||||||||
| WBInteraction000031079 | |||||||||
| WBInteraction000031080 | |||||||||
| WBInteraction000126285 | |||||||||
| WBInteraction000126385 | |||||||||
| WBInteraction000126727 | |||||||||
| WBInteraction000126729 | |||||||||
| WBInteraction000133420 | |||||||||
| WBInteraction000135808 | |||||||||
| WBInteraction000138730 | |||||||||
| WBInteraction000160369 | |||||||||
| WBInteraction000165975 | |||||||||
| WBInteraction000165976 | |||||||||
| WBInteraction000166026 | |||||||||
| WBInteraction000166130 | |||||||||
| WBInteraction000168315 | |||||||||
| WBInteraction000200027 | |||||||||
| WBInteraction000246911 | |||||||||
| WBInteraction000300615 | |||||||||
| WBInteraction000351160 | |||||||||
| WBInteraction000395039 | |||||||||
| WBInteraction000400426 | |||||||||
| WBInteraction000404617 | |||||||||
| WBInteraction000419548 | |||||||||
| WBInteraction000427534 | |||||||||
| WBInteraction000446360 | |||||||||
| WBInteraction000467761 | |||||||||
| WBInteraction000524063 | |||||||||
| WBInteraction000524064 | |||||||||
| WBInteraction000524065 | |||||||||
| WBInteraction000524066 | |||||||||
| WBInteraction000557741 | |||||||||
| WBInteraction000561223 | |||||||||
| Map_info | Map | V | Position | 4.60018 | Error | 0.006913 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F56H9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| YSL59 | |||||||||
| Negative | Negative_clone | W05B10 | |||||||
| Mapping_data | 2_point | 6095 | |||||||
| 6096 | |||||||||
| 6097 | |||||||||
| 6098 | |||||||||
| Multi_point (25) | |||||||||
| Pos_neg_data | 1756 | ||||||||
| 6864 | |||||||||
| 7400 | |||||||||
| Reference (69) | |||||||||
| Method | Gene |
