WormBase Tree Display for Gene: WBGene00003006
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| WBGene00003006 | SMap | S_parent | Sequence | Y71F9B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-17 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y71F9B.5 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | CELE_Y71F9B.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | lin-17 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00089659 | ||||||||
| Allele (234) | |||||||||
| Legacy_information | n671 : adult hermaphrodite slightly uncoordinated long irregularly shaped tail vulva may be nonfunctional many hermaphrodites (50%) have single small protrusion posterior to vulvas some gonadal abnormality and sterility. ES2. Male tail grossly abnormal may rupture during L2 molt ME0. NA5 (n677 (resembles n671); n669 (less penetrant for Muv phenotype) etc.). | ||||||||
| See also e1456, e2257, n669, n671, n677, n698 | |||||||||
| [C.elegansII] n671 : adult hermaphrodite slightly uncoordinated, long, irregularly shaped tail, vulva may be nonfunctional; many hermaphrodites (50%) have single small protrusion posterior to vulvas; some gonadal abnormality and sterility. Abnormally long excretory canals. Diverse asymmetric cell divisions are symmetric or reversed. ES2. Male tail grossly abnormal, may rupture during L2 molt ME0. OA4: n677 (resembles n671), n669 (less penetrant for Muv phenotype), e2257, etc. Cloned: encodes predicted membrane protein(seven TM domains), 28% identity to Drosophila frizzled. [Sternberg and Horvitz 1988; Herman et al. 1995; MT] | |||||||||
| Strain (18) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (56) | |||||||||
| Ortholog (28) | |||||||||
| Paralog | WBGene00000478 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003238 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022242 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003397 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lin-17 encodes one of four C. elegans Frizzled homologs, integral membrane proteins that contain an external cysteine rich domain (CRD) and seven transmembrane domains and that function in a wide variety of species as receptors for Wnt glycoprotein signaling molecules; LIN-17 activity is required for specifying the polarity of a number of asymmetric cell divisions that, in C. elegans, are essential for development of such structures as the vulva, somatic gonad, and tail; LIN-17 is also required for the proper polarity of neuronal migrations along the anterior-posterior axis; genetic interactions indicate that LIN-17 likely functions as a receptor for several different Wnt molecules, including LIN-44 and EGL-20, and that in specifying cell fates, the LIN-17-mediated signaling pathway often functions redundantly with other signaling pathways, including the RTK/Ras pathway; LIN-17, along with CWN-2, CAM-1, and DSH-1, functions as part of a Wnt signaling pathway that regulates ACR-16 localization to postsynaptic regions, a key component of activity-dependent synaptic plasticity; a LIN-17 translational reporter fusion shows membrane-associated expression in all of the Pn.pxx vulval precursor cells, in the descendants of V6 and T in males, in the P11.p and B cells, as well as their daughters, and granddaughters, and weakly in P10.p and its daughters; the reporter fusion does not reveal expression in P7.p, Z1, Z4, and T; LIN-17 is also expressed in muscle arms, where it colocalizes with CAM-1. | Paper_evidence | WBPaper00001096 | |||||
| WBPaper00002543 | |||||||||
| WBPaper00002582 | |||||||||
| WBPaper00003453 | |||||||||
| WBPaper00005116 | |||||||||
| WBPaper00005445 | |||||||||
| WBPaper00006419 | |||||||||
| WBPaper00040939 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Apr 2012 00:00:00 | ||||||||
| Automated_description | Enables receptor tyrosine kinase binding activity. Involved in several processes, including axis specification; cell differentiation; and sex differentiation. Located in neuron projection membrane. Expressed in several structures, including P3.p male; P4.p male; PQR; epithelial cell; and male-specific anatomical entity. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y71F9B.5a | |||||||
| Y71F9B.5b | |||||||||
| Y71F9B.5c | |||||||||
| Corresponding_transcript | Y71F9B.5d | ||||||||
| Y71F9B.5a.1 | |||||||||
| Y71F9B.5a.2 | |||||||||
| Y71F9B.5b.1 | |||||||||
| Y71F9B.5c.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature (30) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00037782 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00101449 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094915 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00113628 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098854 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101347 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101480 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101396 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058182 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (21) | |||||||||
| Drives_construct (16) | |||||||||
| Construct_product (21) | |||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (179) | |||||||||
| Interaction (191) | |||||||||
| Anatomy_function | WBbtf0772 | ||||||||
| WBbtf0773 | |||||||||
| WBbtf0776 | |||||||||
| WBbtf0788 | |||||||||
| WBbtf0818 | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| WBbiopr:00000023 | |||||||||
| WBbiopr:00000073 | |||||||||
| WBbiopr:00000112 | |||||||||
| Map_info | Map | I | Position | -7.32492 | Error | 0.04152 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDp1 | |||||||
| Positive_clone | W09G8 | ||||||||
| Y71F9B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point (3) | ||||||||
| Multi_point (25) | |||||||||
| Pos_neg_data | 4081 | ||||||||
| 4354 | |||||||||
| 5696 | |||||||||
| 6234 | |||||||||
| 6577 | |||||||||
| 6630 | |||||||||
| 6640 | |||||||||
| Landmark_gene | |||||||||
| Reference (267) | |||||||||
| Picture | WBPicture0000013083 | ||||||||
| Remark | Datum inferred from Sawa et al. 1996, lin-17 extends rightward from W09G8, into phage clone lambda6-2. | ||||||||
| Method | Gene |
