WormBase Tree Display for Gene: WBGene00002996
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WBGene00002996 | SMap | S_parent | Sequence | Y54G11A | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lin | ||||||
Reference_allele | WBVar00143988 | ||||||
Allele (113) | |||||||
Possibly_affected_by | WBVar02157230 | ||||||
Legacy_information | e1413amber : adult hermaphrodite vulvaless (penetrance 98%) HME2; adult male wildtype ME3. NA13 (e974amber n308 (both resemble e1413) n308cs (penetrance 95% at 15x 28% at 25x) etc.). | ||||||
See also e974, e1413, e1449, n106, n308, n384, n385, n673, n701, n759, n760, n763, n764 | |||||||
[C.elegansII] e1413amb : adult hermaphrodite vulvaless (penetrance 98%) HME2; adult male wildtype ME3. OA>10: e974amb, n308 (both resemble e1413), n308cs (penetrance 95% at 15C 28% at 25C), n385, n764 etc. Cloned: encodes predicted 33kD protein withPDZ domain, similarity to junction-associated proteins. Mutants delocalize LET-23. [Sulston and Horvitz 1981; MT; SD] | |||||||
Strain | WBStrain00026701 | ||||||
WBStrain00026719 | |||||||
WBStrain00036118 | |||||||
WBStrain00004327 | |||||||
WBStrain00004334 | |||||||
WBStrain00004774 | |||||||
WBStrain00005495 | |||||||
WBStrain00031251 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (36) | |||||||
Contained_in_operon | CEOP2636 | ||||||
Ortholog (48) | |||||||
Paralog | WBGene00014100 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Structured_description | Concise_description | lin-7 encodes a protein that contains a PDZ domain and an L27 domain, two protein interaction domains that likely serve as organizational centers for large macromolecular complexes in polarized cells; LIN-7 is required for proper basolateral localization of the LET-23/EGF receptor in vulval epithelial cells, and along with LIN-2 and LIN-10, forms a protein complex that likely mediates this asymmetric localization with LIN-7 simultaneously binding to the C-terminus of LET-23 and an internal region of LIN-2; a LIN-7 translational reporter fusion indicates that LIN-7 is expressed at intestinal cell junctions; expression in vulval epithelial cells is detected only upon overexpression via heat shock, and reveals localization primarily at the lateral cell junctions of the vulval precursor cells P5.p and P6.p | Paper_evidence | WBPaper00000496 | |||
WBPaper00002436 | |||||||
WBPaper00003215 | |||||||
WBPaper00006521 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 01 Feb 2006 00:00:00 | ||||||
Automated_description | Enables protein-macromolecule adaptor activity and signaling receptor binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and protein localization to basolateral plasma membrane. Located in cell-cell junction. Expressed in gonad; head; somatic gonad precursor; somatic nervous system; and vulval precursor cell. Is an ortholog of human LIN7A (lin-7 homolog A, crumbs cell polarity complex component); LIN7B (lin-7 homolog B, crumbs cell polarity complex component); and LIN7C (lin-7 homolog C, crumbs cell polarity complex component). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | Y54G11A.10a | |||||
Y54G11A.10b | |||||||
Corresponding_CDS_history | Y54G11A.10:wp52 | ||||||
Y54G11A.10a:wp201 | |||||||
Y54G11A.10b:wp201 | |||||||
Corresponding_transcript | Y54G11A.10a.1 | ||||||
Y54G11A.10b.1 | |||||||
Other_sequence (34) | |||||||
Associated_feature | WBsf650744 | ||||||
WBsf224266 | |||||||
Experimental_info | RNAi_result (21) | ||||||
Expr_pattern | Expr690 | ||||||
Expr15957 | |||||||
Expr15960 | |||||||
Expr15963 | |||||||
Expr1021328 | |||||||
Expr1031393 | |||||||
Expr1160856 | |||||||
Expr2013200 | |||||||
Expr2031432 | |||||||
Drives_construct | WBCnstr00000521 | ||||||
WBCnstr00012493 | |||||||
WBCnstr00036298 | |||||||
Construct_product | WBCnstr00000520 | ||||||
WBCnstr00000720 | |||||||
WBCnstr00012493 | |||||||
WBCnstr00036298 | |||||||
Antibody | WBAntibody00000108 | ||||||
WBAntibody00000109 | |||||||
WBAntibody00000974 | |||||||
WBAntibody00001092 | |||||||
Microarray_results (21) | |||||||
Expression_cluster (107) | |||||||
Interaction (128) | |||||||
Map_info | Map | II | Position | 22.9062 | Error | 0.001213 | |
Well_ordered | |||||||
Positive | Positive_clone | Y54G11A | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 493 | |||||
3926 | |||||||
4226 | |||||||
4227 | |||||||
5206 | |||||||
5209 | |||||||
5210 | |||||||
Multi_point (15) | |||||||
Pos_neg_data | 4213 | ||||||
4438 | |||||||
4508 | |||||||
4509 | |||||||
4510 | |||||||
Reference (138) | |||||||
Method | Gene |