WormBase Tree Display for Gene: WBGene00002981
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WBGene00002981 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | ZK593 | ||||||
Identity | Version | 2 | |||||||
Name | CGC_name | lgg-2 | Person_evidence | WBPerson321 | |||||
Sequence_name | ZK593.6 | ||||||||
Molecular_name | ZK593.6a | ||||||||
ZK593.6a.1 | |||||||||
CE50405 | |||||||||
ZK593.6b | |||||||||
CE45416 | |||||||||
ZK593.6b.1 | |||||||||
Other_name | atg-8.2 | Person_evidence | WBPerson649 | ||||||
CELE_ZK593.6 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | lgg-2 | ||||||||
DB_info | Database | AceView | gene | 4L700 | |||||
WormQTL | gene | WBGene00002981 | |||||||
WormFlux | gene | WBGene00002981 | |||||||
NDB | locus_tag | CELE_ZK593.6 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00002981|UniProtKB=Q23536 | |||||||
family | PTHR10969 | ||||||||
NCBI | gene | 177989 | |||||||
RefSeq | protein | NM_001268594.4 | |||||||
NM_001268595.3 | |||||||||
SwissProt | UniProtAcc | Q23536 | |||||||
TREEFAM | TREEFAM_ID | TF312964 | |||||||
TrEMBL | UniProtAcc | E2JKY9 | |||||||
UniProt_GCRP | UniProtAcc | Q23536 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 29 Feb 2008 11:29:00 | WBPerson2970 | Name_change | Other_name | atg-8.2 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lgg | ||||||||
Allele (37) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (27) | |||||||||
Ortholog (40) | |||||||||
Paralog | WBGene00002980 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | lgg-2 encodes an ortholog of the autophagic budding yeast protein Atg8p;LGG-2 is also homologous the light chain 3 (LC3) subunit of themicrotubule-associated proteins 1A and 1B (MAP1A and MAP1B); LGG-2 is predicted to associate with MAP1A and MAP1B and with microtubules and toperhaps play a role in regulating the microtubule-binding activity ofMAP1A and MAP1B; LGG-2 has no obvious function in RNAi assays, and isnot required for either dauer formation or extended lifespan. | Paper_evidence | WBPaper00005654 | |||||
WBPaper00006070 | |||||||||
WBPaper00031504 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 16 Mar 2008 00:00:00 | ||||||||
Automated_description | Predicted to enable microtubule binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to toxic substance; defense response to other organism; and positive regulation of autophagosome maturation. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Expressed in hypodermis; muscle cell; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in glioblastoma; hypertrophic cardiomyopathy; and liver cirrhosis. Is an ortholog of human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha); MAP1LC3B (microtubule associated protein 1 light chain 3 beta); and MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:3068 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6838) | ||||
DOID:11984 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6838) | ||||||
DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6838) | ||||||
Molecular_info | Corresponding_CDS | ZK593.6a | |||||||
ZK593.6b | |||||||||
Corresponding_CDS_history | ZK593.6a:wp246 | ||||||||
Corresponding_transcript | ZK593.6a.1 | ||||||||
ZK593.6b.1 | |||||||||
Other_sequence (78) | |||||||||
Associated_feature (15) | |||||||||
Experimental_info | RNAi_result (21) | ||||||||
Expr_pattern | Expr9088 | ||||||||
Expr11489 | |||||||||
Expr12743 | |||||||||
Expr1019064 | |||||||||
Expr1031381 | |||||||||
Expr1162945 | |||||||||
Expr2013143 | |||||||||
Expr2031375 | |||||||||
Drives_construct | WBCnstr00009398 | ||||||||
WBCnstr00013713 | |||||||||
WBCnstr00019050 | |||||||||
WBCnstr00022725 | |||||||||
WBCnstr00036308 | |||||||||
Construct_product | WBCnstr00009398 | ||||||||
WBCnstr00013713 | |||||||||
WBCnstr00019050 | |||||||||
WBCnstr00022269 | |||||||||
WBCnstr00036308 | |||||||||
Antibody | WBAntibody00002496 | ||||||||
WBAntibody00002979 | |||||||||
Microarray_results (29) | |||||||||
Expression_cluster (162) | |||||||||
Interaction (120) | |||||||||
Map_info | Map | IV | Position | 4.75551 | Error | 0.001217 | |||
Positive | Positive_clone | ZK593 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (48) | |||||||||
Remark (2) | |||||||||
Method | Gene |