WormBase Tree Display for Gene: WBGene00002295
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| WBGene00002295 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | let-19 | Person_evidence | WBPerson533 | |||||
| Sequence_name | K08F8.6 | ||||||||
| Molecular_name | K08F8.6 | ||||||||
| K08F8.6.1 | |||||||||
| CE37536 | |||||||||
| Other_name | psa-7 | ||||||||
| pqn-49 | CGC_data_submission | ||||||||
| TRAP240 | Paper_evidence | WBPaper00019215 | |||||||
| WBPaper00016814 | |||||||||
| WBPaper00011973 | |||||||||
| mdt-13 | Author_evidence | Bourbon H-M | |||||||
| CELE_K08F8.6 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | let-19 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | let | ||||||||
| Reference_allele | WBVar00089001 | ||||||||
| Allele (121) | |||||||||
| Legacy_information | mn19 : larval lethal. NA1. | ||||||||
| [C.elegansII] mn19 : larval lethal. NA1. [Sigurdson et al.; SP] | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00085956 | ||||||||
| 00085957 | |||||||||
| 00085958 | |||||||||
| 00085959 | |||||||||
| 00085960 | |||||||||
| 00110353 | |||||||||
| 00110354 | |||||||||
| 00110355 | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00007384 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00016922 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00019300 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00012647 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00011190 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00019645 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00010594 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | The let-19 gene encodes a protein related to human TRAP240 (thyroid hormone receptor-associated protein 240, OMIM:300182), a transcriptional co-activation complex subunit conserved in yeast, Drosophila, and humans; LET-19 is required for proper asymmetric cell divisions and cell fusions regulated by LIN-44/Wnt and LIN-17/frizzled, as well as for proper development of secondary vulval cell fates as regulated by Notch signaling. | Paper_evidence | WBPaper00000715 | |||||
| WBPaper00012853 | |||||||||
| WBPaper00017142 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of mediator complex. Expressed in several structures, including TL.a; TL.p; TR.a; TR.p; and seam cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and dextro-looped transposition of the great arteries. Is an ortholog of human MED13 (mediator complex subunit 13) and MED13L (mediator complex subunit 13L). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:22474) | ||||
| DOID:0060770 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:22962) | ||||||
| Molecular_info | Corresponding_CDS | K08F8.6 | |||||||
| Corresponding_CDS_history | K08F8.6:wp132 | ||||||||
| Corresponding_transcript | K08F8.6.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf657998 | ||||||||
| WBsf657999 | |||||||||
| WBsf658000 | |||||||||
| WBsf658001 | |||||||||
| WBsf658002 | |||||||||
| WBsf988820 | |||||||||
| WBsf1012745 | |||||||||
| WBsf221813 | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern | Chronogram948 | ||||||||
| Expr2971 | |||||||||
| Expr3488 | |||||||||
| Expr6371 | |||||||||
| Expr13300 | |||||||||
| Expr1013091 | |||||||||
| Expr1031345 | |||||||||
| Expr1154034 | |||||||||
| Expr2013049 | |||||||||
| Expr2031281 | |||||||||
| Drives_construct | WBCnstr00003412 | ||||||||
| WBCnstr00011055 | |||||||||
| WBCnstr00011420 | |||||||||
| WBCnstr00016096 | |||||||||
| WBCnstr00036336 | |||||||||
| Construct_product | WBCnstr00011055 | ||||||||
| WBCnstr00011420 | |||||||||
| WBCnstr00036336 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (140) | |||||||||
| Interaction (52) | |||||||||
| Map_info | Map | II | Position | 0.887503 | Error | 0.002788 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDf46 | |||||||
| mnDf47 | |||||||||
| mnDf48 | |||||||||
| Positive_clone | K08F8 | Inferred_automatically | From CDS info | ||||||
| From sequence, transcript, pseudogene data | |||||||||
| Negative | Outside_rearr | mDf17 | |||||||
| Mapping_data | Multi_point | 1467 | |||||||
| 4168 | |||||||||
| 4659 | |||||||||
| Pos_neg_data (20) | |||||||||
| Reference (24) | |||||||||
| Remark | psa-7 is allelic with let-19 [Sawa H] | ||||||||
| Method | Gene |
