| WBGene00002233 | SMap | S_parent | Sequence | C25B8 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | kqt-1 | Person_evidence | WBPerson655 |
| | | Sequence_name | C25B8.1 |
| | | Molecular_name | C25B8.1a |
| | | | C25B8.1a.1 |
| | | | CE27086 |
| | | | C25B8.1b |
| | | | CE30875 |
| | | | C25B8.1b.1 |
| | | Other_name | klq-1 |
| | | | CELE_C25B8.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | kqt-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | kqt |
| | Allele (129) |
| | Strain | WBStrain00036366 |
| | RNASeq_FPKM (74) |
| | GO_annotation (21) |
| | Ortholog (48) |
| | Paralog (13) |
| | Structured_description | Concise_description | kqt-1 encodes one of three C. elegans KCNQ-like potassium channel subunits that, with respect to humans, is most similar to the KCNQ2-5 subfamily of channel proteins; although loss of KQT-1 activity via large-scale RNAi screens results in no obvious abnormalities, KQT-1 likely functions to regulate cellular excitability as expression of KQT-1 in Xenopus oocytes can produce K+ channel currents that functionally resemble vertebrate M-currents; activity of these KQT-1 channels can be suppressed by coexpression with the human M1 muscarinic receptor and treatment with diacylglycerol analogs; a KQT-1::GFP translational fusion is expressed in pharyngeal muscle cells, in the anterior and posterior mechanosensory neurons ALM and PLM, and in some head neurons. | Paper_evidence | WBPaper00004103 |
| | | | | | WBPaper00025059 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 15 Sep 2005 00:00:00 |
| | | Automated_description | Enables potassium channel activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; intracellular signal transduction; and potassium ion transport. Predicted to be located in plasma membrane and synapse. Predicted to be part of voltage-gated potassium channel complex. Expressed in head neurons; pharyngeal muscle cell; and touch receptor neurons. Used to study developmental and epileptic encephalopathy and long QT syndrome. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autistic disorder; and electroclinical syndrome (multiple). Is an ortholog of human KCNQ4 (potassium voltage-gated channel subfamily Q member 4). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:2843 | Homo sapiens | Paper_evidence | WBPaper00025059 |
| | | | | Accession_evidence | OMIM | 192500 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 07 May 2012 00:00:00 |
| | | DOID:0112202 | Homo sapiens | Paper_evidence | WBPaper00025059 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 07 May 2012 00:00:00 |
| | Potential_model | DOID:0110558 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6298) |
| | | DOID:14264 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6296,HGNC:6297) |
| | | DOID:0080237 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6299) |
| | | DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6298) |
| | | DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6297) |
| | | DOID:0080462 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6296) |
| | Disease_relevance | The kqt genes in elegans (kqt-1, kqt-2, kqt-3) are most similar to the human KCNQ multi-gene family encoding potassium channels; C. elegans kqt-1 defines a subfamily of potassium channel genes along with the human KCNQ2-5 and kqt-3 is most similar to KCNQ1; mutations in human KCNQ genes have been associated with genetic disorders of cardiac arrhythmia and deafness; mutations in KCNQ2 are involved in epileptic encephalopathy (early infantile 7), Myokymia and seizures (benign neonatal 1), mutations in KCNQ3 are associated with neonatal seizures (benign neonatal 2), and those in KCNQ4 are associated with deafness (autosomal dominant 2A); studies in elegans show that the suppression of KCNQ/KQT channels by diacylglycerol (DAG) is dependent on the carboxyl terminal domains of the channel subunits and activated protein kinase C. | Homo sapiens | Paper_evidence | WBPaper00025059 |
| | | | | Accession_evidence | OMIM | 613720 |
| | | | | | | 121200 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 07 May 2012 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000063 |
| | WBDOannot00000301 |
| Molecular_info | Corresponding_CDS | C25B8.1a |
| | | C25B8.1b |
| | Corresponding_transcript | C25B8.1a.1 |
| | | C25B8.1b.1 |
| | Other_sequence | MJC02896_1 |
| | | MJ00417 |
| | | BMC10934_1 |
| | | JI172162.1 |
| | | JI174705.1 |
| | | JI219469.1 |
| | Associated_feature (20) |
| Experimental_info | RNAi_result | WBRNAi00041161 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00001487 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00075817 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00041162 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00011145 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00041160 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr3234 |
| | | Expr1018104 |
| | | Expr1031310 |
| | | Expr1145191 |
| | | Expr2012976 |
| | | Expr2031208 |
| | Drives_construct | WBCnstr00011240 |
| | | WBCnstr00036369 |
| | Construct_product | WBCnstr00011240 |
| | | WBCnstr00036369 |
| | Microarray_results (26) |
| | Expression_cluster | WBPaper00035211:age-1_vs_age-1_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00040420:ALM_PLM_enriched |
| | | WBPaper00040420:FLP_enriched |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smg-2(RNAi)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:NMDA-neuron_enriched |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053368:F.oxysporum_regulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055137:S.maltophilia_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Metformin_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056731:human-amylin_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:paraquat_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADF |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:mu_int_mu_anal |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061340:Neuroblast_ALA_RMED |
| | | WBPaper00061340:T |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:bath-38-Y105E8B.7 |
| | | WBPaper00061651:DVB_enriched |
| | | WBPaper00061651:M1_enriched |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062146:MOG-7-degron_1h_regulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_upregulated |
| | | WBPaper00064735:bet-1B(OE)mys-1(RNAi)_vs_mys-1(RNAi)_downregulated |
| | | WBPaper00064735:mys-1(RNAi)_vs_N2_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C |
| | | WBPaper00065749:Heat-Shock_upregulated_N2 |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11 |
| | | WBPaper00065841:20_0 |
| | | WBPaper00065841:20_2 |
| | | WBPaper00065841:35_0 |
| | | WBPaper00065841:35_1 |
| | | WBPaper00065841:38_2 |
| | | WBPaper00065841:54_0 |
| | | WBPaper00065841:58_0 |
| | | WBPaper00065841:58_1 |
| | | WBPaper00065841:62_0 |
| | | WBPaper00065841:68_1 |
| | | WBPaper00065841:70_0 |
| | | WBPaper00065841:95_0 |
| | | WBPaper00065841:106_0 |
| | | WBPaper00065841:140_0 |
| | | cgc4489_group_20 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_5 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_downregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046548:dafachronic-acid_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | Interaction | WBInteraction000169452 |
| | | WBInteraction000173470 |
| | | WBInteraction000264869 |
| | | WBInteraction000301540 |
| | | WBInteraction000544613 |
| | | WBInteraction000578572 |
| Map_info | Map | X | Position | -2.69956 | Error | 0.014064 |
| | Positive | Positive_clone | C25B8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4237 |
| | Pseudo_map_position |
| Reference (12) |
| Picture | WBPicture0000013535 |
| Remark | Sequence connection from [Thomas JH, Wei A] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
