WormBase Tree Display for Gene: WBGene00002182
expand all nodes | collapse all nodes | view schema
| WBGene00002182 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | kap-1 | Person_evidence | WBPerson589 | |||||
| Sequence_name | F08F8.3 | ||||||||
| Molecular_name | F08F8.3a | ||||||||
| F08F8.3a.1 | |||||||||
| CE54188 | |||||||||
| F08F8.3b | |||||||||
| CE54084 | |||||||||
| F08F8.3a.2 | |||||||||
| F08F8.3b.1 | |||||||||
| Other_name | CELE_F08F8.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | kap-1 | ||||||||
| DB_info | Database | AceView | gene | 3I433 | |||||
| WormQTL | gene | WBGene00002182 | |||||||
| WormFlux | gene | WBGene00002182 | |||||||
| NDB | locus_tag | CELE_F08F8.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002182|UniProtKB=H2KZP1 | |||||||
| family | PTHR15605 | ||||||||
| NCBI | gene | 176041 | |||||||
| RefSeq | protein | NM_001379790.1 | |||||||
| NM_001379791.1 | |||||||||
| TREEFAM | TREEFAM_ID | TF314964 | |||||||
| TrEMBL | UniProtAcc | G5EEE6 | |||||||
| H2KZP1 | |||||||||
| UniProt_GCRP | UniProtAcc | G5EEE6 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kap | ||||||||
| Allele (67) | |||||||||
| Legacy_information | [Siddiqui SS ]. Related to kinesin associated protein by sequence similarity. | ||||||||
| Strain | WBStrain00003712 | ||||||||
| WBStrain00031562 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | kap-1 encodes a kinesin-associated protein that, along with KLP-20 and KLP-11, is part of the C. elegans heterotrimeric kinesin-II motor protein; animals homozygous for a kap-1 loss-of-function mutation have normal cilia and thus display normal dye-filling and osmotic avoidance behavior; however, animals doubly mutant for kap-1 and osm-3, which encodes a homomeric kinesin-II motor protein, do show defects in intraflagellar transport (IFT) indicating that the heteromeric kinsesin-II and homomeric OSM-3 motor protein complexes function redundantly to effect IFT; antibodies to KAP-1 detect high intensity staining in sensory neuron cilia; kap-1 expression in the AWB sensory neurons is positively regulated by FKH-2. | Paper_evidence | WBPaper00003466 | |||||
| WBPaper00004178 | |||||||||
| WBPaper00024501 | |||||||||
| WBPaper00029400 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Oct 2008 00:00:00 | ||||||||
| Automated_description | Contributes to microtubule motor activity. Involved in intraciliary anterograde transport; negative regulation of non-motile cilium assembly; and positive regulation of non-motile cilium assembly. Located in ciliary transition zone and non-motile cilium. Part of axonemal heterotrimeric kinesin-II complex. Expressed in ciliated neurons. Is an ortholog of human KIFAP3 (kinesin associated protein 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F08F8.3a | |||||||
| F08F8.3b | |||||||||
| Corresponding_CDS_history | F08F8.3a:wp275 | ||||||||
| F08F8.3b:wp275 | |||||||||
| Corresponding_transcript | F08F8.3a.1 | ||||||||
| F08F8.3a.2 | |||||||||
| F08F8.3b.1 | |||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf645332 | ||||||||
| WBsf659176 | |||||||||
| WBsf976217 | |||||||||
| WBsf976218 | |||||||||
| WBsf976219 | |||||||||
| WBsf976220 | |||||||||
| WBsf225239 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00012913 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00005204 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044028 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (14) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product (16) | |||||||||
| Antibody | WBAntibody00000217 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (113) | |||||||||
| SAGE_tag | SAGE:ccaaattgatgatgagt | Strand | Sense | ||||||
| Unambiguously_mapped | |||||||||
| SAGE:ccaaattgat | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:tgtcacttttcttacca | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:aaaacttgga | Strand | Antisense | |||||||
| SAGE:cattctaaaccaaatga | Strand | Antisense | |||||||
| SAGE:attgtaataactgcaca | Strand | Antisense | |||||||
| SAGE:ggtacagttgctgagct | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| Interaction (29) | |||||||||
| WBProcess | WBbiopr:00000012 | ||||||||
| Map_info | Map | III | Position | -0.74971 | Error | 0.000513 | |||
| Positive | Positive_clone | F08F8 | Person_evidence | WBPerson589 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4452 | |||||||
| Pseudo_map_position | |||||||||
| Reference (48) | |||||||||
| Remark | There are two kap-1 genes. The CGC_approved one is connected to F08F8.3a/b, the non_CGC_approved one (from the original GenBank/EMBL AF045926) is an other_name of aka-1 and is linked to D1022.7a/b/c [JAH][030120 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
