WormBase Tree Display for Gene: WBGene00002163
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| WBGene00002163 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ist-1 | Person_evidence | WBPerson545 | |||||
| Sequence_name | C54D1.3 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_C54D1.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | ist-1 | ||||||||
| DB_info | Database | AceView | gene | XH757 | |||||
| WormQTL | gene | WBGene00002163 | |||||||
| WormFlux | gene | WBGene00002163 | |||||||
| NDB | locus_tag | CELE_C54D1.3 | |||||||
| NCBI | gene | 180978 | |||||||
| RefSeq | protein | NM_001330903.3 | |||||||
| NM_001373346.3 | |||||||||
| NM_001373345.2 | |||||||||
| NM_076800.7 | |||||||||
| TrEMBL | UniProtAcc | A0A4V0IIP8 | |||||||
| A0A4V0INB3 | |||||||||
| Q18820 | |||||||||
| A0A1C3NSK8 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A4V0IIP8 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 01 Jul 2016 14:56:15 | WBPerson1983 | Event | Acquires_merge | WBGene00044576 | ||||
| Acquires_merge | WBGene00044576 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ist | ||||||||
| Allele (233) | |||||||||
| Strain | WBStrain00033295 | ||||||||
| WBStrain00037950 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00062458 | ||||||||
| 00062459 | |||||||||
| 00062460 | |||||||||
| 00062461 | |||||||||
| 00062462 | |||||||||
| 00062463 | |||||||||
| Ortholog (28) | |||||||||
| Structured_description | Concise_description | ist-1 encodes a pleckstrin homology (PH) and phosphotyrosine binding (PTB) domain-containing insulin receptor substrate (IRS) homolog that negatively regulates lifespan and dauer development; IST-1 potentiates insulin-like signaling, although it is not absolutely required for such signaling under most conditions; in addition to acting through the AGE-1/PI3K branch of the insulin-like signaling pathway, IST-1 may also function in a parallel pathway to activate downstream protein-kinase Bs encoded by akt-1 and akt-2. | Paper_evidence | WBPaper00005614 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable insulin receptor binding activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in dauer larval development; insulin receptor signaling pathway; and short-term memory. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C54D1.3b | |||||||
| C54D1.3c | |||||||||
| C54D1.3d | |||||||||
| C54D1.3e | |||||||||
| Corresponding_CDS_history | C54D1.3:wp128 | ||||||||
| C54D1.3b:wp271 | |||||||||
| C54D1.3c:wp271 | |||||||||
| Corresponding_transcript | C54D1.3b.1 | ||||||||
| C54D1.3c.1 | |||||||||
| C54D1.3d.1 | |||||||||
| C54D1.3e.1 | |||||||||
| Other_sequence | Tcir_isotig31452 | ||||||||
| Tcir_isotig15722 | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr1012662 | ||||||||
| Expr1025581 | |||||||||
| Expr1031266 | |||||||||
| Expr1146049 | |||||||||
| Expr1147097 | |||||||||
| Expr2012871 | |||||||||
| Expr2031105 | |||||||||
| Drives_construct | WBCnstr00023456 | ||||||||
| WBCnstr00036412 | |||||||||
| Construct_product | WBCnstr00023456 | ||||||||
| WBCnstr00036412 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (196) | |||||||||
| Interaction (12) | |||||||||
| Map_info | Map | X | Position | -1.82954 | Error | 0.004648 | |||
| Positive | Positive_clone | C54D1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Sequence connection from [Wolkow C] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
