WormBase Tree Display for Gene: WBGene00002163
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WBGene00002163 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | ist-1 | Person_evidence | WBPerson545 | |||
Sequence_name | C54D1.3 | ||||||
Molecular_name (12) | |||||||
Other_name | CELE_C54D1.3 | Accession_evidence | NDB | BX284606 | |||
Public_name | ist-1 | ||||||
DB_info | Database | AceView | gene | XH757 | |||
WormQTL | gene | WBGene00002163 | |||||
WormFlux | gene | WBGene00002163 | |||||
NDB | locus_tag | CELE_C54D1.3 | |||||
NCBI | gene | 180978 | |||||
RefSeq | protein | NM_001330903.3 | |||||
NM_001373346.3 | |||||||
NM_001373345.2 | |||||||
NM_076800.7 | |||||||
TrEMBL | UniProtAcc | A0A4V0IIP8 | |||||
A0A4V0INB3 | |||||||
Q18820 | |||||||
A0A1C3NSK8 | |||||||
UniProt_GCRP | UniProtAcc | A0A4V0IIP8 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Acquires_merge | WBGene00044576 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ist | ||||||
Allele (233) | |||||||
Strain | WBStrain00033295 | ||||||
WBStrain00037950 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00062458 | ||||||
00062459 | |||||||
00062460 | |||||||
00062461 | |||||||
00062462 | |||||||
00062463 | |||||||
Ortholog (28) | |||||||
Structured_description | Concise_description | ist-1 encodes a pleckstrin homology (PH) and phosphotyrosine binding (PTB) domain-containing insulin receptor substrate (IRS) homolog that negatively regulates lifespan and dauer development; IST-1 potentiates insulin-like signaling, although it is not absolutely required for such signaling under most conditions; in addition to acting through the AGE-1/PI3K branch of the insulin-like signaling pathway, IST-1 may also function in a parallel pathway to activate downstream protein-kinase Bs encoded by akt-1 and akt-2. | Paper_evidence | WBPaper00005614 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable insulin receptor binding activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in dauer larval development; insulin receptor signaling pathway; and short-term memory. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C54D1.3b | |||||
C54D1.3c | |||||||
C54D1.3d | |||||||
C54D1.3e | |||||||
Corresponding_CDS_history | C54D1.3:wp128 | ||||||
C54D1.3b:wp271 | |||||||
C54D1.3c:wp271 | |||||||
Corresponding_transcript | C54D1.3b.1 | ||||||
C54D1.3c.1 | |||||||
C54D1.3d.1 | |||||||
C54D1.3e.1 | |||||||
Other_sequence | Tcir_isotig31452 | ||||||
Tcir_isotig15722 | |||||||
Associated_feature (14) | |||||||
Experimental_info | RNAi_result (12) | ||||||
Expr_pattern | Expr1012662 | ||||||
Expr1025581 | |||||||
Expr1031266 | |||||||
Expr1146049 | |||||||
Expr1147097 | |||||||
Expr2012871 | |||||||
Expr2031105 | |||||||
Drives_construct | WBCnstr00023456 | ||||||
WBCnstr00036412 | |||||||
Construct_product | WBCnstr00023456 | ||||||
WBCnstr00036412 | |||||||
Microarray_results (28) | |||||||
Expression_cluster (196) | |||||||
Interaction (12) | |||||||
Map_info | Map | X | Position | -1.82954 | Error | 0.004648 | |
Positive | Positive_clone | C54D1 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (13) | |||||||
Remark | Sequence connection from [Wolkow C] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |