WormBase Tree Display for Gene: WBGene00002073
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| WBGene00002073 | SMap | S_parent | Sequence | F26B1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ima-2 | |||||||
| Sequence_name | F26B1.3 | ||||||||
| Molecular_name | F26B1.3 | ||||||||
| F26B1.3.1 | |||||||||
| CE09675 | |||||||||
| Other_name | 1G893 | Accession_evidence | EMBL | AF326936 | |||||
| CELE_F26B1.3 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | ima-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ima | ||||||||
| Allele (33) | |||||||||
| Strain | WBStrain00003849 | ||||||||
| WBStrain00003850 | |||||||||
| WBStrain00003851 | |||||||||
| WBStrain00040617 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00002072 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00002074 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009956 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ima-2 encodes one of three C. elegans importin alpha proteins; IMA-2 is predicted to function as an adaptor protein that regulates import of nuclear proteins; during development, ima-2 activity is required for normal germline and embryonic mitoses, specifically for proper chromosome segregration and nuclear reassembly; IMA-2 expression is detected in germ cells, oocytes, and early embryonic cells in a dynamic pattern that depends upon the stage of the cell cycle: in germ cells and early embryonic cells at interphase, IMA-2 is cytoplasmic and nuclear envelope-associated, while in oocytes, IMA-2 is cytoplasmic and intranuclear; during mitoses (prometaphase until telophase), IMA-2 surrounds condensed chromosomes, but does not associate with the mitotic spindle; early somatic expression of maternal IMA-2 is diluted upon cell division, with appreciable expression subsequently seen only in the germ line. | Paper_evidence | WBPaper00004711 | |||||
| WBPaper00005484 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Oct 2006 00:00:00 | ||||||||
| Automated_description | Enables nuclear import signal receptor activity. Involved in several processes, including organelle organization; protein import into nucleus; and regulation of chromosome segregation. Located in cytoplasm and nuclear envelope. Expressed in Z2; Z3; and germ line. Is an ortholog of human KPNA2 (karyopherin subunit alpha 2) and KPNA7 (karyopherin subunit alpha 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21839) | ||||
| Molecular_info | Corresponding_CDS | F26B1.3 | |||||||
| Corresponding_transcript | F26B1.3.1 | ||||||||
| Other_sequence (68) | |||||||||
| Associated_feature | WBsf976724 | ||||||||
| WBsf976725 | |||||||||
| WBsf976726 | |||||||||
| WBsf976727 | |||||||||
| WBsf976728 | |||||||||
| WBsf217793 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr1340 | ||||||||
| Expr1341 | |||||||||
| Expr2436 | |||||||||
| Expr1015623 | |||||||||
| Expr1031226 | |||||||||
| Expr1149508 | |||||||||
| Expr2012726 | |||||||||
| Expr2030963 | |||||||||
| Drives_construct | WBCnstr00036474 | ||||||||
| Construct_product | WBCnstr00036474 | ||||||||
| Antibody | WBAntibody00000368 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (247) | |||||||||
| Interaction (209) | |||||||||
| Map_info | Map | I | Position | 0.958776 | Error | 0.01404 | |||
| Positive | Positive_clone | F26B1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4438 | |||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Sequence connection from [Geles KG, Adam SA]. krb 13/11/01 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
