WormBase Tree Display for Gene: WBGene00002073

WBGene00002073 SMap: S_parent: Sequence: F26B1
  Identity: Version: 1
    Name: CGC_name: ima-2
      Sequence_name: F26B1.3
      Molecular_name: F26B1.3
        F26B1.3.1
        CE09675
      Other_name: 1G893 Accession_evidence: EMBL AF326936
        CELE_F26B1.3 Accession_evidence: NDB BX284601
      Public_name: ima-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ima
    Allele (33)
    Strain: WBStrain00003849
      WBStrain00003850
      WBStrain00003851
      WBStrain00040617
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog (49)
    Paralog: WBGene00002072 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002074 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009956 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: ima-2 encodes one of three C. elegans importin alpha proteins; IMA-2 is predicted to function as an adaptor protein that regulates import of nuclear proteins; during development, ima-2 activity is required for normal germline and embryonic mitoses, specifically for proper chromosome segregration and nuclear reassembly; IMA-2 expression is detected in germ cells, oocytes, and early embryonic cells in a dynamic pattern that depends upon the stage of the cell cycle: in germ cells and early embryonic cells at interphase, IMA-2 is cytoplasmic and nuclear envelope-associated, while in oocytes, IMA-2 is cytoplasmic and intranuclear; during mitoses (prometaphase until telophase), IMA-2 surrounds condensed chromosomes, but does not associate with the mitotic spindle; early somatic expression of maternal IMA-2 is diluted upon cell division, with appreciable expression subsequently seen only in the germ line. Paper_evidence: WBPaper00004711
            WBPaper00005484
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Oct 2006 00:00:00
      Automated_description: Enables nuclear import signal receptor activity. Involved in several processes, including organelle organization; protein import into nucleus; and regulation of chromosome segregation. Located in cytoplasm and nuclear envelope. Expressed in Z2; Z3; and germ line. Is an ortholog of human KPNA2 (karyopherin subunit alpha 2) and KPNA7 (karyopherin subunit alpha 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: EFO:MONDO:0014769 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:21839)
  Molecular_info: Corresponding_CDS: F26B1.3
    Corresponding_transcript: F26B1.3.1
    Other_sequence (68)
    Associated_feature: WBsf976724
      WBsf976725
      WBsf976726
      WBsf976727
      WBsf976728
      WBsf217793
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr1340
      Expr1341
      Expr2436
      Expr1015623
      Expr1031226
      Expr1149508
      Expr2012726
      Expr2030963
    Drives_construct: WBCnstr00036474
    Construct_product: WBCnstr00036474
    Antibody: WBAntibody00000368
    Microarray_results (22)
    Expression_cluster (247)
    Interaction: WBInteraction000028603
      WBInteraction000028929
      WBInteraction000030905
      WBInteraction000135549
      WBInteraction000135550
      WBInteraction000137978
      WBInteraction000151119
      WBInteraction000151567
      WBInteraction000170804
      WBInteraction000172799
      WBInteraction000183528
      WBInteraction000188171
      WBInteraction000192818
      WBInteraction000193998
      WBInteraction000198988
      WBInteraction000199559
      WBInteraction000201544
      WBInteraction000206865
      WBInteraction000208604
      WBInteraction000208655
      WBInteraction000210010
      WBInteraction000212890
      WBInteraction000213120
      WBInteraction000219538
      WBInteraction000220253
      WBInteraction000221296
      WBInteraction000221386
      WBInteraction000222877
      WBInteraction000223089
      WBInteraction000225597
      WBInteraction000226567
      WBInteraction000229921
      WBInteraction000230171
      WBInteraction000231602
      WBInteraction000233600
      WBInteraction000233745
      WBInteraction000235836
      WBInteraction000236688
      WBInteraction000237561
      WBInteraction000238213
      WBInteraction000240630
      WBInteraction000241836
      WBInteraction000247059
      WBInteraction000247321
      WBInteraction000247640
      WBInteraction000248621
      WBInteraction000251195
      WBInteraction000253022
      WBInteraction000253485
      WBInteraction000258811
      WBInteraction000264463
      WBInteraction000265486
      WBInteraction000267305
      WBInteraction000268840
      WBInteraction000271359
      WBInteraction000271473
      WBInteraction000271976
      WBInteraction000272337
      WBInteraction000276670
      WBInteraction000277838
      WBInteraction000278756
      WBInteraction000279031
      WBInteraction000282878
      WBInteraction000284818
      WBInteraction000289174
      WBInteraction000289354
      WBInteraction000289834
      WBInteraction000289981
      WBInteraction000292758
      WBInteraction000293048
      WBInteraction000295622
      WBInteraction000297445
      WBInteraction000298203
      WBInteraction000301431
      WBInteraction000304825
      WBInteraction000305872
      WBInteraction000306233
      WBInteraction000306235
      WBInteraction000307236
      WBInteraction000308886
      WBInteraction000310950
      WBInteraction000311511
      WBInteraction000313137
      WBInteraction000315699
      WBInteraction000318295
      WBInteraction000320499
      WBInteraction000322061
      WBInteraction000322102
      WBInteraction000322536
      WBInteraction000322691
      WBInteraction000322716
      WBInteraction000322889
      WBInteraction000323560
      WBInteraction000325455
      WBInteraction000325785
      WBInteraction000329371
      WBInteraction000332004
      WBInteraction000335134
      WBInteraction000336322
      WBInteraction000338265
      WBInteraction000338542
      WBInteraction000338696
      WBInteraction000339167
      WBInteraction000345262
      WBInteraction000346921
      WBInteraction000348705
      WBInteraction000348797
      WBInteraction000349363
      WBInteraction000349816
      WBInteraction000349830
      WBInteraction000350227
      WBInteraction000351107
      WBInteraction000352880
      WBInteraction000352946
      WBInteraction000353683
      WBInteraction000356211
      WBInteraction000356497
      WBInteraction000357500
      WBInteraction000358660
      WBInteraction000359716
      WBInteraction000361049
      WBInteraction000364654
      WBInteraction000365466
      WBInteraction000366470
      WBInteraction000366625
      WBInteraction000368044
      WBInteraction000371446
      WBInteraction000372316
      WBInteraction000380443
      WBInteraction000380690
      WBInteraction000383249
      WBInteraction000384185
      WBInteraction000385515
      WBInteraction000385558
      WBInteraction000388795
      WBInteraction000391413
      WBInteraction000392323
      WBInteraction000393982
      WBInteraction000399136
      WBInteraction000401177
      WBInteraction000401345
      WBInteraction000403203
      WBInteraction000403894
      WBInteraction000406500
      WBInteraction000407877
      WBInteraction000408253
      WBInteraction000409281
      WBInteraction000410701
      WBInteraction000411676
      WBInteraction000414710
      WBInteraction000416401
      WBInteraction000416442
      WBInteraction000418479
      WBInteraction000422572
      WBInteraction000423553
      WBInteraction000424235
      WBInteraction000424856
      WBInteraction000425822
      WBInteraction000425969
      WBInteraction000426324
      WBInteraction000427681
      WBInteraction000430251
      WBInteraction000433622
      WBInteraction000435959
      WBInteraction000436560
      WBInteraction000436912
      WBInteraction000439637
      WBInteraction000439682
      WBInteraction000439858
      WBInteraction000442590
      WBInteraction000442819
      WBInteraction000445213
      WBInteraction000450046
      WBInteraction000450371
      WBInteraction000451428
      WBInteraction000452282
      WBInteraction000452754
      WBInteraction000453878
      WBInteraction000454635
      WBInteraction000456170
      WBInteraction000456389
      WBInteraction000460994
      WBInteraction000502602
      WBInteraction000511478
      WBInteraction000522838
      WBInteraction000539008
      WBInteraction000540470
      WBInteraction000542327
      WBInteraction000542328
      WBInteraction000542329
      WBInteraction000550684
      WBInteraction000554385
      WBInteraction000557887
      WBInteraction000557989
      WBInteraction000560234
      WBInteraction000563969
      WBInteraction000565386
      WBInteraction000567426
      WBInteraction000567621
      WBInteraction000570292
      WBInteraction000573449
      WBInteraction000574496
      WBInteraction000574707
      WBInteraction000577011
      WBInteraction000577143
      WBInteraction000579594
      WBInteraction000585518
      WBInteraction000585734
      WBInteraction000586612
  Map_info: Map: I Position: 0.958776 Error: 0.01404
    Positive: Positive_clone: F26B1 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4438
    Pseudo_map_position
  Reference (13)
  Remark: Sequence connection from [Geles KG, Adam SA]. krb 13/11/01
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene