WormBase Tree Display for Gene: WBGene00002069
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| WBGene00002069 | SMap | S_parent | Sequence | C04F12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ikb-1 | Person_evidence | WBPerson1122 | |||||
| Sequence_name | C04F12.3 | ||||||||
| Molecular_name | C04F12.3 | ||||||||
| C04F12.3.1 | |||||||||
| CE19676 | |||||||||
| Other_name | CELE_C04F12.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | ikb-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ikb | ||||||||
| Allele (53) | |||||||||
| Possibly_affected_by | WBVar02153293 | ||||||||
| Strain | WBStrain00029112 | ||||||||
| WBStrain00051604 | |||||||||
| WBStrain00051846 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00018666 | ||||||||
| 00018667 | |||||||||
| 00018668 | |||||||||
| 00018669 | |||||||||
| 00018670 | |||||||||
| 00018671 | |||||||||
| 00018672 | |||||||||
| 00018673 | |||||||||
| 00109966 | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00006780 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00012124 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00011240 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00007252 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ikb-1 encodes an ortholog of human BCL3 (OMIM:109560) that physically interacts with the checkpoint protein MRT-2; ikb-1(nr2019) and ikb-1(nr2027) mutants display no obvious phenotype other than shortened lifespan; mutation of BCL3 is frequently associated with recurring translocations found in the neoplastic cells of patients with chronic lymphocytic leukemia, and has been implicated in cell cycle control (perhaps via apoptosis). | Paper_evidence | WBPaper00004589 | |||||
| WBPaper00004692 | |||||||||
| WBPaper00005039 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable NF-kappaB binding activity. Involved in defense response to Gram-negative bacterium. Located in cytoplasm. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Is an ortholog of human NFKB2 (nuclear factor kappa B subunit 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0081152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7795) | ||||
| Molecular_info | Corresponding_CDS | C04F12.3 | |||||||
| Corresponding_transcript | C04F12.3.1 | ||||||||
| Other_sequence (38) | |||||||||
| Associated_feature | WBsf643607 | ||||||||
| WBsf643608 | |||||||||
| WBsf656781 | |||||||||
| WBsf984774 | |||||||||
| WBsf984775 | |||||||||
| WBsf1010411 | |||||||||
| WBsf1010412 | |||||||||
| WBsf218325 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00002902 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00114630 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028440 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039630 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091427 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075903 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067972 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001332 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9563 | ||||||||
| Expr15289 | |||||||||
| Expr1026817 | |||||||||
| Expr1031222 | |||||||||
| Expr1143726 | |||||||||
| Expr2012714 | |||||||||
| Expr2030950 | |||||||||
| Drives_construct | WBCnstr00036478 | ||||||||
| Construct_product | WBCnstr00014128 | ||||||||
| WBCnstr00036478 | |||||||||
| Regulate_expr_cluster | WBPaper00060445:ikb-1(nr2027)_downregulated_L1 | ||||||||
| WBPaper00060445:ikb-1(nr2027)_downregulated_L4 | |||||||||
| WBPaper00060445:ikb-1(nr2027)_upregulated_L1 | |||||||||
| WBPaper00060445:ikb-1(nr2027)_upregulated_L4 | |||||||||
| WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4 | |||||||||
| WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (210) | |||||||||
| Interaction (127) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | I | Position | 3.85381 | Error | 0.000485 | |||
| Positive | Positive_clone | C04F12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4781 | |||||||
| Pseudo_map_position | |||||||||
| Reference (18) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
