WormBase Tree Display for Gene: WBGene00002066

WBGene00002066 Evidence: Person_evidence: WBPerson1666
  SMap: S_parent: Sequence: M110
  Identity: Version: 1
    Name: CGC_name: ifg-1 Person_evidence: WBPerson1666
      Sequence_name: M110.4
      Molecular_name (15)
      Other_name: CELE_M110.4 Accession_evidence: NDB BX284602
      Public_name: ifg-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ifg
    Allele: WBVar00092465
      WBVar01499702
      WBVar01626915
      WBVar00226145
      WBVar01498435
      WBVar01695769
      WBVar01695770
      WBVar01695771
      WBVar00748865
      WBVar00748866
      WBVar00748867
      WBVar00748868
      WBVar00748869
      WBVar00748870
      WBVar00748871
      WBVar00748872
      WBVar00748873
      WBVar00748874
      WBVar01438730
      WBVar01949201
      WBVar00748875
      WBVar01438731
      WBVar00748876
      WBVar01438733
      WBVar00748877
      WBVar01438734
      WBVar00748878
      WBVar00748879
      WBVar00748880
      WBVar00748881
      WBVar00748882
      WBVar00748883
      WBVar00748884
      WBVar00748885
      WBVar00748886
      WBVar00748887
      WBVar00748888
      WBVar00748889
      WBVar00748890
      WBVar00748891
      WBVar00748892
      WBVar00748893
      WBVar00748894
      WBVar00748895
      WBVar00748896
      WBVar00748897
      WBVar00748898
      WBVar00748899
      WBVar00748900
      WBVar00748901
      WBVar00748902
      WBVar00748903
      WBVar00748904
      WBVar00748905
      WBVar00748906
      WBVar00748907
      WBVar00104630
      WBVar01242104
      WBVar00070909
      WBVar01242107
      WBVar00371735
      WBVar00371736
      WBVar00371737
      WBVar00371738
      WBVar00371739
      WBVar00371740
      WBVar00371741
      WBVar00371742
      WBVar00371743
      WBVar00371744
      WBVar00371745
      WBVar00371746
      WBVar02069267
      WBVar01498940
      WBVar02151769
      WBVar00551727
    Strain: WBStrain00001270
      WBStrain00024079
      WBStrain00036060
      WBStrain00024080
    RNASeq_FPKM (74)
    GO_annotation: 00003642
      00003643
      00003644
      00003645
      00003646
      00006169
      00006170
      00109964
      00109965
    Ortholog (59)
    Structured_description: Concise_description: ifg-1 encodes, by alternative splicing, two orthologs of the translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G); by homology, IFG-1 is predicted to function in poly(A) tail-dependent translation initiation; loss of ifg-1 activity in adult animals extends lifespan. Paper_evidence: WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
            WBPaper00029008
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 25 Jul 2007 00:00:00
      Automated_description: Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol. Part of eukaryotic translation initiation factor 4F complex. Expressed in several structures, including gonad. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Is an ortholog of human EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060892 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3296)
  Molecular_info: Corresponding_CDS: M110.4a
      M110.4b
      M110.4c
      M110.4d
      M110.4e
    Corresponding_CDS_history: M110.4d:wp270
      M110.4e:wp261
    Corresponding_transcript: M110.4a.1
      M110.4b.1
      M110.4c.1
      M110.4d.1
      M110.4e.1
    Other_sequence: CGC01168_1
      CBC07565_1
    Associated_feature (24)
  Experimental_info: RNAi_result (88)
    Expr_pattern: Chronogram1630
      Expr2003
      Expr4023
      Expr1021338
      Expr1031219
      Expr1154648
      Expr2012694
      Expr2030930
    Drives_construct: WBCnstr00002165
      WBCnstr00036481
    Construct_product: WBCnstr00036481
    Regulate_expr_cluster: WBPaper00039835:ifg-1_downregulated
      WBPaper00039835:ifg-1_upregulated
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
    Antibody: WBAntibody00001408
      WBAntibody00001409
      WBAntibody00001410
      WBAntibody00001654
    Microarray_results (36)
    Expression_cluster (170)
    Interaction (263)
    WBProcess: WBbiopr:00000001
  Map_info: Map: II Position: 0.750204 Error: 0.00036
    Positive: Positive_clone: M110 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5120
        4617
        5014
    Pseudo_map_position
  Reference (33)
  Remark: ifg-1 related ESTs: Longest EST's: yk450c12, yk1009e02. Many other partial EST's. Person_evidence: WBPerson1666
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene