WormBase Tree Display for Gene: WBGene00002050

WBGene00002050 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: ifa-1 Person_evidence: WBPerson105
            WBPerson293
      Sequence_name: F38B2.1
      Molecular_name (15)
      Other_name: Cel IF A1 Accession_evidence: EMBL X70834
        CelIF a1
        A1 Paper_evidence: WBPaper00006137
        CELE_F38B2.1 Accession_evidence: NDB BX284606
      Public_name: ifa-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ifa
    Allele (77)
    Strain: WBStrain00036052
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00058318 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00037027 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00035019 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00036339 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00036340 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00139438 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00135092 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00228350 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g3057 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g13917 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g12067 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g18737 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g15852 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g25191 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g2829 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g18721 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g5981 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g28805 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g12651 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00054.g2777 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_04985.g19265 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-ifa-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold450.g1305 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01252.g19601 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01152 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_023752 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01363 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g14879 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0085500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g20036 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00238933 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00093410 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00108837 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00273533 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00257258 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00291505 Trichuris muris From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-020424-3 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020424-4 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:6638 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      MGI:96699 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
      MGI:96701 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
      MGI:1861586 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
      MGI:1923500 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
      MGI:3607712 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
      MGI:2385030 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
      MGI:3588209 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
      MGI:3646318 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:2911 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
      RGD:3159 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
      RGD:3160 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
      RGD:2984 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1310865 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1359576 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1359597 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1359664 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1359272 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1565564 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:727894 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1302968 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1303216 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1303297 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1303078 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1588056 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1584538 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
      RGD:1583372 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
    Paralog (12)
    Structured_description: Concise_description: IFA-1 encodes an essential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-1 is required for survival past the L1 larva stage, and a normal intestine; IFA-1 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; IFA-1 is predicted to function as a structural component of the cytoskeleton, and is required for larval development and normal intestinal morphology; ifa-1 is expressed in amphid sensory neurons, in tail neurons and other unidentified neurons, some pharyngeal muscles, the pharyngeal-intestinal valve, the vulva, and the rectum. Paper_evidence: WBPaper00001981
            WBPaper00004761
            WBPaper00006137
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cellular localization; heterochromatin formation; and nucleus organization. Located in intermediate filament. Expressed in several structures, including egg-laying apparatus; excretory cell; neurons; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Is an ortholog of human LMNB2 (lamin B2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6638)
      DOID:0070296 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6638)
      DOID:0080299 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6638)
  Molecular_info: Corresponding_CDS: F38B2.1a
      F38B2.1b
      F38B2.1c
      F38B2.1d
      F38B2.1e
    Corresponding_CDS_history: F38B2.1:wp83
    Corresponding_transcript: F38B2.1a.1
      F38B2.1b.1
      F38B2.1c.1
      F38B2.1d.1
      F38B2.1e.1
    Other_sequence (241)
    Associated_feature (14)
  Experimental_info: RNAi_result (48)
    Expr_pattern: Expr1495
      Expr2762
      Expr1013956
      Expr1031203
      Expr1150559
      Expr2012676
      Expr2030912
    Drives_construct: WBCnstr00010937
      WBCnstr00036494
    Construct_product: WBCnstr00010937
      WBCnstr00036494
    Microarray_results (39)
    Expression_cluster (212)
    Interaction (72)
  Map_info: Map: X Position: 2.86537 Error: 0.001386
    Positive: Positive_clone: F38B2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4945
        4421
        4442
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene