WormBase Tree Display for Gene: WBGene00002048

WBGene00002048 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: B0244
  Identity: Version: 1
    Name: CGC_name: ida-1 Person_evidence: WBPerson71
      Sequence_name: B0244.2
      Molecular_name: B0244.2
        B0244.2.1
        CE31867
      Other_name: ia2 Accession_evidence: EMBL AF126740
        CELE_B0244.2 Accession_evidence: NDB BX284603
      Public_name: ida-1
    DB_info: Database: AceView gene 3G855
        WormQTL gene WBGene00002048
        WormFlux gene WBGene00002048
        NDB locus_tag CELE_B0244.2
        Panther gene CAEEL|WormBase=WBGene00002048|UniProtKB=G5EGJ5
          family PTHR46106
        NCBI gene 175807
        RefSeq protein NM_065844.7
        SwissProt UniProtAcc G5EGJ5
        TREEFAM TREEFAM_ID TF351976
        UniProt_GCRP UniProtAcc G5EGJ5
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ida
    Allele (167)
    Strain: WBStrain00003830
      WBStrain00003831
      WBStrain00003832
      WBStrain00035598
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (39)
    Paralog (64)
    Structured_description: Concise_description: ida-1 encodes a protein tyrosine phosphatase-like receptor, orthologous to the mammalian type I diabetes autoantigens IA-2 and phogrin that are expressed in dense core vesicles of neuroendocrine tissue and involved in regulated protein secretion; in C. elegans, IDA-1 appears to be required for regulating presynaptic neurotransmission and in particular, for the neuropeptidergic control of egg-laying; ida-1 interacts genetically with unc-31 and unc-64, which encode proteins required for dense core vesicle fusion and exocytosis; ida-1 expression is detected in a subset of neurons in the anterior nerve ring, the ventral nerve cord, the tail, and the vulva, including the VC vulval motoneurons and the HSN egg-laying neurons; ida-1 is also detected in the vulval uv1 cells, non-neuronal cells that contain neurosecretory-like vesicles. Paper_evidence: WBPaper00004433
            WBPaper00004518
            WBPaper00019367
            WBPaper00019564
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Involved in positive regulation of anterior/posterior axon guidance; positive regulation of neurotransmitter secretion; and ventral cord development. Located in dense core granule and synapse. Expressed in several structures, including buccal cavity; neurons; preanal ganglion; somatic nervous system; and uv1. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Is an ortholog of human PTPRN2 (protein tyrosine phosphatase receptor type N2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9351 Homo sapiens Paper_evidence: WBPaper00046108
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Feb 2017 00:00:00
      DOID:14330 Homo sapiens Paper_evidence: WBPaper00046108
          Curator_confirmed: WBPerson324
          Date_last_updated: 04 Feb 2015 00:00:00
    Potential_model: DOID:9744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9676,HGNC:9677)
      DOID:11716 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9677)
  Models_disease_in_annotation: WBDOannot00000345
    WBDOannot00000388
  Molecular_info: Corresponding_CDS: B0244.2
    Corresponding_CDS_history: B0244.2:wp86
      B0244.2b:wp18
    Corresponding_transcript: B0244.2.1
    Other_sequence (97)
    Associated_feature (18)
  Experimental_info: RNAi_result: WBRNAi00000950 Inferred_automatically: RNAi_primary
      WBRNAi00038791 Inferred_automatically: RNAi_primary
      WBRNAi00038790 Inferred_automatically: RNAi_primary
      WBRNAi00028026 Inferred_automatically: RNAi_primary
      WBRNAi00009628 Inferred_automatically: RNAi_primary
      WBRNAi00005822 Inferred_automatically: RNAi_primary
      WBRNAi00009627 Inferred_automatically: RNAi_primary
    Expr_pattern (14)
    Drives_construct (12)
    Construct_product: WBCnstr00000646
      WBCnstr00005801
      WBCnstr00006969
      WBCnstr00008654
      WBCnstr00018579
      WBCnstr00036495
    Antibody: WBAntibody00000901
    Microarray_results (21)
    Expression_cluster (299)
    Interaction (63)
  Map_info: Map: III Position: -1.44641 Error: 6.5e-05
    Positive: Positive_clone: B0244 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4431
    Pseudo_map_position
  Reference (32)
  Remark: Sequence connection from [Zahn TA, Macmorris MA]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene