WormBase Tree Display for Gene: WBGene00001898

WBGene00001898 SMap: S_parent: Sequence: M163
  Identity: Version: 2
    Name: CGC_name: his-24 Person_evidence: WBPerson160
      Sequence_name: M163.3
      Molecular_name: M163.3
        M163.3.1
        CE12450
      Other_name: HH1
        H1.1 Paper_evidence: WBPaper00004630
        Histone H1.1 Paper_evidence: WBPaper00053345
        CELE_M163.3 Accession_evidence: NDB BX284606
      Public_name: his-24
    DB_info: Database: AceView gene XP109
        WormQTL gene WBGene00001898
        WormFlux gene WBGene00001898
        NDB locus_tag CELE_M163.3
        Panther gene CAEEL|WormBase=WBGene00001898|UniProtKB=P10771
          family PTHR11467
        NCBI gene 181545
        RefSeq protein NM_078009.7
        SwissProt UniProtAcc P10771
        UniProt_GCRP UniProtAcc P10771
    Species: Caenorhabditis elegans
    History: Version_change (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: his
    Allele (33)
    Legacy_information: [C.elegansII] NMK. Histone type H1. Contains intron, encodes polyadenylated RNA. [Sanicola et al. 1990]
    Strain: WBStrain00031772
      WBStrain00034782
      WBStrain00034807
      WBStrain00006458
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog: WBGene00040348 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
      WBGene00058501 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00148070 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00132085 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
      WBGene00121502 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
      WBGene00091178 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00068514 Caenorhabditis remanei From_analysis: OMA
            WormBase-Compara
      WBGene00103491 Pristionchus pacificus From_analysis: OMA
      WBGene00175902 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      WBGene00029507 Caenorhabditis briggsae From_analysis: Inparanoid_8
      WBGene00040335 Caenorhabditis briggsae From_analysis: Inparanoid_8
      CSP21.g9577 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g1242 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g11747 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g2213 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g17283 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g20878 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g22029 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g22030 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g7903 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g16235 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g3274 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g3275 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g4739 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g26055 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g27654 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g10318 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_01052.g15504 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_04440.g18852 Caenorhabditis angaria From_analysis: WormBase-Compara
      Csp11.Scaffold564.g4009 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold629.g10190 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold629.g11881 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01786.g23127 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01642 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_05582 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_012323 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_012373 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_012414 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_012441 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_025690 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g14413 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g9555 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0147600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g20593 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00126857 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00070150 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00072146 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00076741 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00278528 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00278880 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00257204 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000006048 Saccharomyces cerevisiae From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            Panther
      FB:FBgn0051617 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053807 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053861 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053852 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053816 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053804 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053813 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053810 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053828 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053834 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053849 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053819 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053855 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053843 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053801 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053831 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053837 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053840 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053864 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053858 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053822 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053846 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0053825 Drosophila melanogaster From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-030131-337 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
      HGNC:4714 Homo sapiens From_analysis: Inparanoid
            OrthoInspector
            Panther
      HGNC:18463 Homo sapiens From_analysis: OrthoFinder
            Panther
            SonicParanoid
      MGI:95893 Mus musculus From_analysis: Inparanoid
            OrthoInspector
            Panther
      RGD:2777 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            Panther
    Paralog: WBGene00001852 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001853 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001854 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001855 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001856 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001857 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: his-24 encodes one of eight C. elegans H1 linker histones; HIS-24, along with the histone deacetylase SIR-2.1 and the Enhancer of zeste E(Z) ortholog MES-2, plays a key role in heterochromatin regulation and thus, in regulation of fertility and embryonic development; specifically, HIS-24 and SIR-2.1 are essential for maintenance of the histone H3K27me3 mark at subtelomeric regions in the C. elegans germ line; HIS-24 interacts specifically with the H3 K27 region, either when unmodified or when in the trimethylated (me3) state; HIS-24 is ubiquitously expressed and localizes to nuclei; in addition, in germ cells, the majority of HIS-24 localizes to the cytoplasm, in a manner dependent upon SIR-2.1 and MES proteins. Paper_evidence: WBPaper00004630
            WBPaper00028983
            WBPaper00033091
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Nov 2010 00:00:00
      Automated_description: Enables H3K27me3 modified histone binding activity. Involved in defense response to Gram-positive bacterium and negative regulation of gene expression. Located in chromosome, telomeric region; cytoplasm; and nucleus. Expressed in several structures, including germ line and gonad. Is an ortholog of human H1-0 (H1.0 linker histone) and H1-8 (H1.8 linker histone). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: M163.3
    Corresponding_transcript: M163.3.1
    Other_sequence (76)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00090698 Inferred_automatically: RNAi_primary
      WBRNAi00017226 Inferred_automatically: RNAi_primary
      WBRNAi00089638 Inferred_automatically: RNAi_primary
      WBRNAi00027719 Inferred_automatically: RNAi_primary
      WBRNAi00089608 Inferred_automatically: RNAi_primary
      WBRNAi00050989 Inferred_automatically: RNAi_primary
      WBRNAi00076026 Inferred_automatically: RNAi_primary
      WBRNAi00076031 Inferred_automatically: RNAi_primary
      WBRNAi00064599 Inferred_automatically: RNAi_primary
      WBRNAi00076030 Inferred_automatically: RNAi_primary
    Expr_pattern (15)
    Drives_construct: WBCnstr00000408
      WBCnstr00000430
      WBCnstr00002522
      WBCnstr00007280
      WBCnstr00009451
      WBCnstr00013533
      WBCnstr00015453
      WBCnstr00015912
      WBCnstr00036616
    Construct_product (293)
    Regulate_expr_cluster: WBPaper00041609:hpl-1_hpl-2_downregulated
      WBPaper00041609:hpl-1_hpl-2_upregulated
    Antibody: WBAntibody00000355
      WBAntibody00001210
      WBAntibody00002298
    Microarray_results (26)
    Expression_cluster (392)
    Interaction (157)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: X Position: 16.7093 Error: 0.005353
    Positive: Positive_clone: LCEH1A
        M163 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (29)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene