WormBase Tree Display for Gene: WBGene00001898

WBGene00001898 SMap: S_parent: Sequence: M163
  Identity: Version: 2
    Name: CGC_name: his-24 Person_evidence: WBPerson160
      Sequence_name: M163.3
      Molecular_name: M163.3
        M163.3.1
        CE12450
      Other_name: HH1
        H1.1 Paper_evidence: WBPaper00004630
        Histone H1.1 Paper_evidence: WBPaper00053345
        CELE_M163.3 Accession_evidence: NDB BX284606
      Public_name: his-24
    DB_info: Database: AceView gene XP109
        WormQTL gene WBGene00001898
        WormFlux gene WBGene00001898
        NDB locus_tag CELE_M163.3
        Panther gene CAEEL|WormBase=WBGene00001898|UniProtKB=P10771
          family PTHR11467
        NCBI gene 181545
        RefSeq protein NM_078009.7
        SwissProt UniProtAcc P10771
        UniProt_GCRP UniProtAcc P10771
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 12 Nov 2010 10:24:40 WBPerson2970 Name_change: Other_name: H1.1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: his
    Allele (33)
    Legacy_information: [C.elegansII] NMK. Histone type H1. Contains intron, encodes polyadenylated RNA. [Sanicola et al. 1990]
    Strain: WBStrain00031772
      WBStrain00034782
      WBStrain00034807
      WBStrain00006458
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (80)
    Paralog: WBGene00001852 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001853 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001854 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001855 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001856 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001857 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: his-24 encodes one of eight C. elegans H1 linker histones; HIS-24, along with the histone deacetylase SIR-2.1 and the Enhancer of zeste E(Z) ortholog MES-2, plays a key role in heterochromatin regulation and thus, in regulation of fertility and embryonic development; specifically, HIS-24 and SIR-2.1 are essential for maintenance of the histone H3K27me3 mark at subtelomeric regions in the C. elegans germ line; HIS-24 interacts specifically with the H3 K27 region, either when unmodified or when in the trimethylated (me3) state; HIS-24 is ubiquitously expressed and localizes to nuclei; in addition, in germ cells, the majority of HIS-24 localizes to the cytoplasm, in a manner dependent upon SIR-2.1 and MES proteins. Paper_evidence: WBPaper00004630
            WBPaper00028983
            WBPaper00033091
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Nov 2010 00:00:00
      Automated_description: Enables H3K27me3 modified histone binding activity. Involved in defense response to Gram-positive bacterium and negative regulation of gene expression. Located in chromosome, telomeric region; cytoplasm; and nucleus. Expressed in several structures, including germ line and gonad. Is an ortholog of human H1-0 (H1.0 linker histone) and H1-8 (H1.8 linker histone). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: M163.3
    Corresponding_transcript: M163.3.1
    Other_sequence (76)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00090698 Inferred_automatically: RNAi_primary
      WBRNAi00017226 Inferred_automatically: RNAi_primary
      WBRNAi00089638 Inferred_automatically: RNAi_primary
      WBRNAi00027719 Inferred_automatically: RNAi_primary
      WBRNAi00089608 Inferred_automatically: RNAi_primary
      WBRNAi00050989 Inferred_automatically: RNAi_primary
      WBRNAi00076026 Inferred_automatically: RNAi_primary
      WBRNAi00076031 Inferred_automatically: RNAi_primary
      WBRNAi00064599 Inferred_automatically: RNAi_primary
      WBRNAi00076030 Inferred_automatically: RNAi_primary
    Expr_pattern (15)
    Drives_construct: WBCnstr00000408
      WBCnstr00000430
      WBCnstr00002522
      WBCnstr00007280
      WBCnstr00009451
      WBCnstr00013533
      WBCnstr00015453
      WBCnstr00015912
      WBCnstr00036616
    Construct_product (293)
    Regulate_expr_cluster: WBPaper00041609:hpl-1_hpl-2_downregulated
      WBPaper00041609:hpl-1_hpl-2_upregulated
    Antibody: WBAntibody00000355
      WBAntibody00001210
      WBAntibody00002298
    Microarray_results (26)
    Expression_cluster (392)
    Interaction: WBInteraction000005548
      WBInteraction000006126
      WBInteraction000108925
      WBInteraction000110403
      WBInteraction000114187
      WBInteraction000114194
      WBInteraction000124614
      WBInteraction000135546
      WBInteraction000158133
      WBInteraction000158165
      WBInteraction000158203
      WBInteraction000158210
      WBInteraction000158214
      WBInteraction000158220
      WBInteraction000158224
      WBInteraction000158225
      WBInteraction000158226
      WBInteraction000158227
      WBInteraction000158228
      WBInteraction000158229
      WBInteraction000158230
      WBInteraction000158231
      WBInteraction000158234
      WBInteraction000158239
      WBInteraction000158245
      WBInteraction000158254
      WBInteraction000158261
      WBInteraction000158265
      WBInteraction000158274
      WBInteraction000158281
      WBInteraction000158294
      WBInteraction000158298
      WBInteraction000158307
      WBInteraction000158314
      WBInteraction000158317
      WBInteraction000158324
      WBInteraction000158327
      WBInteraction000158334
      WBInteraction000158338
      WBInteraction000158344
      WBInteraction000163893
      WBInteraction000164414
      WBInteraction000169319
      WBInteraction000169326
      WBInteraction000169327
      WBInteraction000169328
      WBInteraction000169329
      WBInteraction000169330
      WBInteraction000169331
      WBInteraction000169335
      WBInteraction000169339
      WBInteraction000169346
      WBInteraction000169348
      WBInteraction000169361
      WBInteraction000169368
      WBInteraction000169374
      WBInteraction000169380
      WBInteraction000169387
      WBInteraction000173260
      WBInteraction000174148
      WBInteraction000182741
      WBInteraction000201826
      WBInteraction000223439
      WBInteraction000239828
      WBInteraction000255043
      WBInteraction000257239
      WBInteraction000258846
      WBInteraction000262822
      WBInteraction000281745
      WBInteraction000282640
      WBInteraction000283117
      WBInteraction000290992
      WBInteraction000296723
      WBInteraction000299326
      WBInteraction000299826
      WBInteraction000300354
      WBInteraction000300819
      WBInteraction000303630
      WBInteraction000304272
      WBInteraction000304917
      WBInteraction000306176
      WBInteraction000311720
      WBInteraction000319316
      WBInteraction000323714
      WBInteraction000325111
      WBInteraction000327028
      WBInteraction000338647
      WBInteraction000344940
      WBInteraction000348136
      WBInteraction000348736
      WBInteraction000349393
      WBInteraction000351461
      WBInteraction000355917
      WBInteraction000357280
      WBInteraction000368346
      WBInteraction000371084
      WBInteraction000374050
      WBInteraction000377137
      WBInteraction000380633
      WBInteraction000382443
      WBInteraction000383700
      WBInteraction000388565
      WBInteraction000390199
      WBInteraction000398633
      WBInteraction000400808
      WBInteraction000405755
      WBInteraction000419679
      WBInteraction000420559
      WBInteraction000420850
      WBInteraction000424849
      WBInteraction000424943
      WBInteraction000425999
      WBInteraction000434348
      WBInteraction000438323
      WBInteraction000439053
      WBInteraction000441221
      WBInteraction000445465
      WBInteraction000448820
      WBInteraction000450443
      WBInteraction000451807
      WBInteraction000454214
      WBInteraction000502763
      WBInteraction000502764
      WBInteraction000502765
      WBInteraction000502766
      WBInteraction000502767
      WBInteraction000519056
      WBInteraction000519057
      WBInteraction000540169
      WBInteraction000540645
      WBInteraction000541211
      WBInteraction000541212
      WBInteraction000541213
      WBInteraction000541583
      WBInteraction000541585
      WBInteraction000541586
      WBInteraction000541589
      WBInteraction000541590
      WBInteraction000551489
      WBInteraction000552810
      WBInteraction000553502
      WBInteraction000556101
      WBInteraction000559403
      WBInteraction000560837
      WBInteraction000561216
      WBInteraction000562120
      WBInteraction000562650
      WBInteraction000562751
      WBInteraction000563515
      WBInteraction000563933
      WBInteraction000565788
      WBInteraction000569331
      WBInteraction000571980
      WBInteraction000572477
      WBInteraction000572797
      WBInteraction000580046
      WBInteraction000581892
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: X Position: 16.7093 Error: 0.005353
    Positive: Positive_clone: LCEH1A
        M163 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (29)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene