WormBase Tree Display for Gene: WBGene00001692

WBGene00001692 Evidence: Paper_evidence: WBPaper00003717
  SMap: S_parent: Sequence: W05E7
  Identity: Version: 1
    Name: CGC_name: grd-3 Person_evidence: WBPerson83
      Sequence_name: W05E7.1
      Molecular_name: W05E7.1
        W05E7.1.1
        CE34103
      Other_name: CELE_W05E7.1 Accession_evidence: NDB BX284604
      Public_name: grd-3
    DB_info: Database: AceView gene 4E205
        WormQTL gene WBGene00001692
        WormFlux gene WBGene00001692
        NDB locus_tag CELE_W05E7.1
        Panther gene CAEEL|WormBase=WBGene00001692|UniProtKB=Q9TYW7
          family PTHR46706
        NCBI gene 177109
        RefSeq protein NM_067945.6
        TREEFAM TREEFAM_ID TF316923
        TrEMBL UniProtAcc Q9TYW7
        UniProt_GCRP UniProtAcc Q9TYW7
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: grd
    Allele (15)
    Strain: WBStrain00032786
    RNASeq_FPKM (74)
    GO_annotation: 00097722
      00097723
      00097724
      00097725
    Ortholog (19)
    Paralog (25)
    Structured_description: Concise_description: grd-3 encodes a hedgehog-like protein, with an N-terminal signalsequence and a C-terminal Ground domain; GRD-3 is expressed in adultanterior and posterior seam cells, overlapping GRD-5 expression; GRD-3is also strongly expressed upon infection with the gram-negativebacterium Serratia marcescens, indicating that GRD-3 may be part of C.elegans' innate immunity response; the Ground domain is predicted toform a cysteine-crosslinked protein acting as an intercellular signal,and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOGproteins; GRD-3 is weakly required for normal molting; GRD-3 is alsorequired for normal growth to full size and locomotion; all of theserequirements may reflect common defects in cholesterol-dependenthedgehog-like signalling or in vesicle trafficking. Paper_evidence: WBPaper00002823
            WBPaper00003717
            WBPaper00005382
            WBPaper00005654
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Predicted to enable signaling receptor binding activity. Involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular region. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: W05E7.1
    Corresponding_CDS_history: W05E7.1:wp100
    Corresponding_transcript: W05E7.1.1
    Other_sequence: FD517194.1
      CSC00396_1
      CJC00964_1
      CBC04410_1
      FD514418.1
      FD517785.1
      CRC10049_1
      FD517127.1
      CSC00396_2
    Associated_feature: WBsf645873
      WBsf995962
      WBsf995963
      WBsf995964
      WBsf228100
  Experimental_info: RNAi_result: WBRNAi00077017 Inferred_automatically: RNAi_primary
      WBRNAi00103567 Inferred_automatically: RNAi_primary
      WBRNAi00075992 Inferred_automatically: RNAi_primary
      WBRNAi00054823 Inferred_automatically: RNAi_primary
      WBRNAi00019622 Inferred_automatically: RNAi_primary
      WBRNAi00076992 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr635
      Expr1966
      Expr1029206
      Expr1031010
      Expr1158365
      Expr2012233
      Expr2030469
    Drives_construct: WBCnstr00006286
      WBCnstr00012459
      WBCnstr00036764
    Construct_product: WBCnstr00036764
    Microarray_results (19)
    Expression_cluster: WBPaper00005700:secreted_protein
      WBPaper00028451:Oogenic_protein
      WBPaper00030922:glycosylated_protein
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038213:E.coli(LF82)_72h_downregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00040412:germline-regulated_daf-12_target
      WBPaper00040990:PA14_downregulated
      WBPaper00042215:wdr-23(tm1817)_downregulated
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00044037:eat-2_downregulated
      WBPaper00044246:pgrn-1_ced-1_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(gk119)_downregulated
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045420:fertilization_upregulated_protein
      WBPaper00045521:Spermatogenic
      WBPaper00045774:clk-1_upregulated
      WBPaper00045861:wdr-5(ok1417)_downregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00046887:WNT-target
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049018:ham-3(RNAi)_upregulated
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049635:dop-1(vs100)_downregulated
      WBPaper00049736:15deg-then-25deg(12hr)_upregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051352:Long-Term-Association-Memory_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054191:H3.3(null)_L1_downregulated
      WBPaper00054192:cold-shock_downregulated
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055013:hmg-4(RNAi)_upregulated
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056039:efa-6(tm3124)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056284:ints-1(RNAi)_upregulated
      WBPaper00056284:ints-11(RNAi)_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056586:mpk-2(ok219)_upregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00056617:adr-1_upregulated_L4_transcript
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00058711:paraquat_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058927:high-redox-state_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059117:B.subtilis_downregulated
      WBPaper00059175:hlh-17p-XBP-1_downregulated
      WBPaper00059194:klf-1(RNAi)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059895:wounding_downregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_downregulated_mRNA
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tdc-1(n3419)_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061081:E.faecalis_downregulated_N2
      WBPaper00061081:E.faecalis_downregulated_skpo-1(ok1640)
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061340:ASE_parent
      WBPaper00061340:Seam_cell
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:mup-2-unc-87_284
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00061692:acivicin_upregulated
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061800:miR-85(n4117)_downregulated_20C
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00062056:lin-15B(we23)_downregulated
      WBPaper00062056:lin-37(n758)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062167:mbl-1(tm1563)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062347:blmp-1(tm548)_upregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062456:doxycycline_downregulated_N2_protein
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064156:lbp-3(overexpress)_downregulated
      WBPaper00064156:lipl-4(overexpress)_downregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064841:tent-5(tm3504)_downregulated_transcript
      WBPaper00064952:Day5_vs_L4_upregulated_25C
      WBPaper00065074:glna(-)_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:25C_vs_15C_upregulated_AFD
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065272:dhgd-1(tm6671)_downregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065392:Lb.delbrueckii_downregulated
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:Lb.rhamnosus_downregulated
      WBPaper00065623:34
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:0_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066038:mip-1(how5)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066118:cyclobutrifluram_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_1_5
      cgc4489_group_9
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026952:class_F
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00034739:RIL17moreRIL14
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036286:Pattern_I
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038462:aging_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040876:mir-35_downregulated
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045015:nhr-25(RNAi)_downregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045374:Benzene_upregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053550:daf-19(m86)_upregulated_AdultDay2
      WBPaper00053688:E.faecalis_downregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_C
    Interaction: WBInteraction000309835
      WBInteraction000310799
      WBInteraction000416885
      WBInteraction000519374
      WBInteraction000549461
      WBInteraction000549462
      WBInteraction000574865
      WBInteraction000585659
      WBInteraction000586349
    WBProcess: WBbiopr:00000123
  Map_info: Map: IV Position: -4.09953 Error: 0.033813
    Positive: Positive_clone (2)
    Pseudo_map_position
  Reference: WBPaper00003717
    WBPaper00005382
    WBPaper00011801
    WBPaper00025183
    WBPaper00026841
    WBPaper00028754
    WBPaper00031588
    WBPaper00061547
    WBPaper00064105
  Remark: yk66e9 spans only grd-3, which contains just ground domain. grd-3, grd-10, and grd-13 form a cluster, grd-3 and grd-13 are paralogous to the grd-4 and grd-14 cluster. Paper_evidence: WBPaper00003717
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene