WormBase Tree Display for Interaction: WBInteraction000549461
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| WBInteraction000549461 | Interaction_type | Regulatory | Change_of_expression_level | |
|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene (28) | |||
| Interaction_summary | "we repeated the mRNA tagging experiment and performed qPCR to analyze gene expression levels for more than 100 of the putative target genes identified by microarray analysis (data not shown). Twentyseven of the genes were upregulated in response to Wnt pathway activation when assayed by this method, and 12 of these were also downregulated in response to Wnt pathway inhibition (Table S5)." | |||
| Detection_method | Construct | |||
| Transgene | ||||
| RT_PCR | ||||
| Regulation_level | Transcriptional | |||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000029 | |
| Anatomy_term | WBbt:0005753 | |||
| WBbt:0007809 | ||||
| Paper | WBPaper00046887 | |||
| Remark | Table S5; "We conditionally activated Wnt signalingat the time of the L2/L3 molt using hs::delNTbar-1, which encodesa heat shock inducible variant of BAR-1/b-catenin lacking the aminoterminal region required for degradation in the absence of signaling(Gleason and Eisenmann 2010; Jackson et al. 2014)" |
