WormBase Tree Display for Gene: WBGene00001688
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WBGene00001688 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F22B7 | ||||||
Identity | Version | 1 | |||||||
Name (5) | |||||||||
DB_info | Database | AceView | gene | 3J719 | |||||
WormQTL | gene | WBGene00001688 | |||||||
WormFlux | gene | WBGene00001688 | |||||||
NDB | locus_tag | CELE_F22B7.13 | |||||||
NCBI | gene | 176210 | |||||||
RefSeq | protein | NM_066499.5 | |||||||
SwissProt | UniProtAcc | Q95QJ7 | |||||||
TREEFAM | TREEFAM_ID | TF318159 | |||||||
UniProt_GCRP | UniProtAcc | Q95QJ7 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | gpr | ||||||||
Allele (26) | |||||||||
Strain | WBStrain00036782 | ||||||||
WBStrain00007343 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (15) | |||||||||
Contained_in_operon | CEOP3875 | ||||||||
Ortholog (20) | |||||||||
Paralog | WBGene00001689 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Inparanoid_8 | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | gpr-1 encodes an extremely similar (97% identity) paralog of GPR-2; GPR-1(and GPR-2) proteins have two N-terminal tetratricopeptide-like motifs anda C-terminal GoLoco/GPR (G protein regulatory) motif, the latter of whichhas also been found in mammalian AGS3 and Drosophila Pins; GPR-1 isrequired for normally asymmetrical cleavage of one-cell embryos; GPR-1 andGPR-2 form a high molecular weight (~700 kDa) complex that includes LIN-5;GPR-1 binds GDP-bound GOA-1 via a GoLoco/GPR motif, and depends on RIC-8for this binding; GPR-1/2, GOA-1, and LIN-5 colocalize at the cortex ofearly embryos; cortical enrichment of GPR-1 requires LIN-5, PAR-2, PAR-3,and LET-99; the asymmetric distribution of GPR-1/2 and LET-99 in EMS cellsis dependent on MES-1/SRC-1 signaling; GPR-1/2 is co-immunoprecipitatedwith RIC-8 and GPA-16. | Paper_evidence | WBPaper00005878 | |||||
WBPaper00005918 | |||||||||
WBPaper00005945 | |||||||||
WBPaper00006289 | |||||||||
WBPaper00024244 | |||||||||
WBPaper00024481 | |||||||||
WBPaper00026807 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 06 Sep 2006 00:00:00 | ||||||||
Automated_description | Enables G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Expressed in P lineage cell. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | F22B7.13 | |||||||
Corresponding_transcript | F22B7.13.1 | ||||||||
Other_sequence | CJC06602_1 | ||||||||
CBC04217_1 | |||||||||
Associated_feature | WBsf225448 | ||||||||
Experimental_info | RNAi_result (55) | ||||||||
Expr_pattern | Expr2564 | ||||||||
Expr10765 | |||||||||
Expr1031007 | |||||||||
Expr1149216 | |||||||||
Expr2012213 | |||||||||
Expr2030449 | |||||||||
Drives_construct | WBCnstr00036768 | ||||||||
Construct_product | WBCnstr00007804 | ||||||||
WBCnstr00007805 | |||||||||
WBCnstr00010003 | |||||||||
WBCnstr00036768 | |||||||||
Antibody | WBAntibody00000624 | ||||||||
WBAntibody00000631 | |||||||||
WBAntibody00000632 | |||||||||
WBAntibody00000783 | |||||||||
WBAntibody00001312 | |||||||||
WBAntibody00001392 | |||||||||
Microarray_results (17) | |||||||||
Expression_cluster (123) | |||||||||
Interaction (82) | |||||||||
WBProcess | WBbiopr:00000017 | ||||||||
Map_info | Map | III | Position | -0.210379 | Error | 0.001277 | |||
Positive | Positive_clone | F22B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (69) | |||||||||
Remark | Sequence connection from [Ahringer JA] | ||||||||
Gene renamed from ags-3.2 to gpr-1 following advice from [Hodgkin J], [020808 krb] | |||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |