WormBase Tree Display for Gene: WBGene00001583

WBGene00001583 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: M163
  Identity: Version: 1
    Name: CGC_name: gfi-3 Person_evidence: WBPerson1796
      Sequence_name: M163.4
      Molecular_name: M163.4
        M163.4.1
        CE12452
      Other_name: apc-5 CGC_data_submission
        CELE_M163.4 Accession_evidence: NDB BX284606
      Public_name: gfi-3
    DB_info: Database: AceView gene XP101
        WormQTL gene WBGene00001583
        WormFlux gene WBGene00001583
        NDB locus_tag CELE_M163.4
        Panther gene CAEEL|WormBase=WBGene00001583|UniProtKB=Q93903
          family PTHR12830
        NCBI gene 181544
        RefSeq protein NM_078008.7
        SwissProt UniProtAcc Q93903
        TREEFAM TREEFAM_ID TF105444
        UniProt_GCRP UniProtAcc Q93903
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gfi
    Allele (90)
    RNASeq_FPKM (74)
    GO_annotation: 00086869
      00086870
      00086871
      00086872
      00086873
      00086874
      00086875
      00086876
      00109034
    Ortholog (38)
    Paralog: WBGene00013443 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: gfi-3 is also known as apc-5, encoding a distant homolog of the human anaphase promoting complex subunit APC5, but is most closely related to its C. elegans paralog such-1; gfi-3(RNAi) animals are generally unable to progress through meiotic divisions; initially they produce reduced numbers of viable embryos mixed with inviable embryos, but then show severe germline maintenance defects and become sterile. Paper_evidence: WBPaper00005096
            WBPaper00013611
            WBPaper00037671
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Expressed in germ line and sperm. Is an ortholog of human ANAPC5 (anaphase promoting complex subunit 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: M163.4
    Corresponding_transcript: M163.4.1
    Other_sequence: CJC00794_1
    Associated_feature: WBsf663558
      WBsf236675
      WBsf236676
  Experimental_info: RNAi_result: WBRNAi00017227 Inferred_automatically: RNAi_primary
      WBRNAi00050990 Inferred_automatically: RNAi_primary
      WBRNAi00002212 Inferred_automatically: RNAi_primary
      WBRNAi00008231 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9271
      Expr1016994
      Expr1030949
      Expr1154696
      Expr2012029
      Expr2030265
    Drives_construct: WBCnstr00007686
      WBCnstr00013867
      WBCnstr00036845
    Construct_product: WBCnstr00036845
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032976:non_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037946:LIN-39_interacting
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050094:mes-6(bn66)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets
      WBPaper00057162:meg-3_meg-4_downregulated_sRNA
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:ABarpaaa_lineage
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Ciliated_non_amphid_neuron
      WBPaper00061340:g2_parent
      WBPaper00061340:Neuroblast_AFD_RMD
      WBPaper00061340:Neuroblast_ALA_RMED
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061340:Neuroblast_BAG_SMDVx
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:PVQ_parent
      WBPaper00061527:nrde-3-tra-4_10484
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:met-1(bn200)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064502:spe-44(fx110)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066093:E.coli-purE_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_5_3
      cgc4489_group_6
      WBPaper00025032:cluster_13
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_F
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00042258:DA1877_downregulated_GravidAdult
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (61)
  Map_info: Map: X Position: 16.7086
    Positive: Positive_clone: M163 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005096
    WBPaper00006435
    WBPaper00037671
    WBPaper00038491
    WBPaper00055090
  Remark: Sequence connection from [Qadota H, Kaibuchi K]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene