WormBase Tree Display for Gene: WBGene00001578
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| WBGene00001578 | SMap | S_parent | Sequence | R12A1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ges-1 | Person_evidence | WBPerson411 | |||||
| WBPerson36909 | |||||||||
| WBPerson7188 | |||||||||
| Sequence_name | R12A1.4 | ||||||||
| Molecular_name | R12A1.4 | ||||||||
| R12A1.4.1 | |||||||||
| CE28763 | |||||||||
| Other_name | ges1 | Accession_evidence | EMBL | M96145 | |||||
| cest-18 | |||||||||
| CELE_R12A1.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | ges-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 May 2019 14:10:26 | WBPerson1983 | Name_change | CGC_name | ges-1 | ||||
| Other_name | cest-18 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ges | ||||||||
| Allele (102) | |||||||||
| Legacy_information | cal : electrophoretic variant of major gut esterase. No other phenotype. ES1 ME3. NA6 (ca4 etc. : all electrophoretic variants). | ||||||||
| [C.elegansII] cal : electrophoretic variant of major gut esterase. No other phenotype. ES1 ME3. OA>10: ca4, ca6 etc (all electrophoretic variants), ca6ca7, ca6ca9, ca10, ca11 etc (null mutations, major gut esterase activity absent, no other phenotype) pk47, pk49 (Tc1 insertions; deletionderivatives also obtained). Cloned: encodes gut-specific esterase,expressed from 200-cell stage onward. Extensive promoter analysis. [McGhee et al. 1990, Aamodt et al. 1991, JM] | |||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00052613 | ||||||||
| 00052614 | |||||||||
| 00052615 | |||||||||
| 00052616 | |||||||||
| 00052617 | |||||||||
| 00052618 | |||||||||
| 00052619 | |||||||||
| 00052620 | |||||||||
| 00052621 | |||||||||
| Ortholog (75) | |||||||||
| Paralog (40) | |||||||||
| Structured_description | Concise_description | ges-1 encodes a gut-specific type B carboxylesterase; by homology, GES-1 hydrolyzes carboxylic ester substrates to yield an alcohol and a carboxylic anion, however, loss of GES-1 activity via mutation or RNAi does not result in any obvious abnormalities; GES-1 is expressed solely in the intestinal, or E, lineage from the 4 E-cell stage of gut development through adulthood; GES-1 contains a C-terminal endoplasmic reticulum (ER) retention sequence, KDEL, which suggests that it localizes to the ER lumen; GES-1 expression in the gut appears to be positively regulated by ELT-2, a gut-specific GATA-type transcription factor expressed throughout the C. elegans life cycle and essential for normal gut development. | Paper_evidence | WBPaper00000869 | |||||
| WBPaper00001305 | |||||||||
| WBPaper00001695 | |||||||||
| WBPaper00003129 | |||||||||
| WBPaper00004994 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Feb 2005 00:00:00 | ||||||||
| Automated_description | Enables carboxylesterase activity. Involved in cellular catabolic process. Located in peroxisome. Expressed in pharynx. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and stomach cancer. Is an ortholog of human CES1 (carboxylesterase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1863) | ||||
| DOID:3119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1863) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1863) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1863) | ||||||
| Molecular_info | Corresponding_CDS | R12A1.4 | |||||||
| Corresponding_transcript | R12A1.4.1 | ||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf919554 | ||||||||
| WBsf919555 | |||||||||
| WBsf919556 | |||||||||
| WBsf919557 | |||||||||
| WBsf919558 | |||||||||
| WBsf999325 | |||||||||
| WBsf1019177 | |||||||||
| WBsf233333 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00063184 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00017787 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051827 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr683 | ||||||||
| Expr684 | |||||||||
| Expr10319 | |||||||||
| Expr10320 | |||||||||
| Expr11336 | |||||||||
| Expr1028070 | |||||||||
| Expr1030944 | |||||||||
| Expr1155486 | |||||||||
| Expr2012022 | |||||||||
| Expr2030258 | |||||||||
| Drives_construct (93) | |||||||||
| Construct_product | WBCnstr00018781 | ||||||||
| WBCnstr00018782 | |||||||||
| WBCnstr00036850 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (203) | |||||||||
| Interaction (43) | |||||||||
| Map_info | Map | V | Position | -18.9452 | Error | 0.035025 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | JM#L0001 | |||||||
| R12A1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 3138 | |||||||
| 3139 | |||||||||
| 3140 | |||||||||
| 3141 | |||||||||
| Multi_point | 1188 | ||||||||
| Pos_neg_data | 3142 | ||||||||
| 3143 | |||||||||
| 3144 | |||||||||
| 4540 | |||||||||
| 5191 | |||||||||
| Reference (109) | |||||||||
| Method | Gene |
