WormBase Tree Display for Gene: WBGene00001543
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| WBGene00001543 | SMap | S_parent | Sequence | ZK896 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gcy-18 | Person_evidence | WBPerson655 | |||||
| Sequence_name | ZK896.8 | ||||||||
| Molecular_name | ZK896.8 | ||||||||
| ZK896.8.1 | |||||||||
| CE42602 | |||||||||
| Other_name | gcy-26 | ||||||||
| CELE_ZK896.8 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | gcy-18 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gcy | ||||||||
| Allele (291) | |||||||||
| Strain | WBStrain00029460 | ||||||||
| WBStrain00037252 | |||||||||
| WBStrain00022003 | |||||||||
| WBStrain00021997 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (37) | |||||||||
| Structured_description | Concise_description | gcy-18 encodes a receptor-type guanylyl cyclase that, along with gcy-8 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-18 functions redundantly with gcy-8 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; in addition, microarray experiments indicate that gcy-18 expression is induced in daf-16(RNAi); daf-2(RNAi) double mutants and repressed in daf-2(RNAi) mutants, suggesting that GCY-18 activity may contribute to a shortened lifespan; consistent with this, loss of gcy-18 activity via RNAi does result in lifespan extension; GCY-18 is expressed exclusively in the AFD thermosensory neurons, where it localizes to sensory endings. | Paper_evidence | WBPaper00002839 | |||||
| WBPaper00005976 | |||||||||
| WBPaper00026643 | |||||||||
| WBPaper00027040 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 07 Aug 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in detection of temperature stimulus; thermosensory behavior; and thermotaxis. Located in microvillus membrane and neuron projection terminus. Expressed in intestine and nervous system. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | ZK896.8 | |||||||
| Corresponding_CDS_history | ZK896.8:wp190 | ||||||||
| Corresponding_transcript | ZK896.8.1 | ||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf646493 | ||||||||
| WBsf980904 | |||||||||
| WBsf980905 | |||||||||
| WBsf980906 | |||||||||
| WBsf998262 | |||||||||
| WBsf998263 | |||||||||
| WBsf998264 | |||||||||
| WBsf229340 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00059812 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00022221 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063228 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063229 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram346 | ||||||||
| Expr3852 | |||||||||
| Expr3855 | |||||||||
| Expr4535 | |||||||||
| Expr7267 | |||||||||
| Expr15356 | |||||||||
| Expr1027877 | |||||||||
| Expr1163242 | |||||||||
| Expr2011982 | |||||||||
| Expr2030219 | |||||||||
| Drives_construct | WBCnstr00001522 | ||||||||
| WBCnstr00003912 | |||||||||
| WBCnstr00011694 | |||||||||
| WBCnstr00011697 | |||||||||
| WBCnstr00018574 | |||||||||
| WBCnstr00020283 | |||||||||
| WBCnstr00036874 | |||||||||
| Construct_product | WBCnstr00011697 | ||||||||
| WBCnstr00036874 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (99) | |||||||||
| Interaction | WBInteraction000005543 | ||||||||
| WBInteraction000500833 | |||||||||
| WBInteraction000500834 | |||||||||
| WBInteraction000524550 | |||||||||
| WBInteraction000524660 | |||||||||
| WBInteraction000525001 | |||||||||
| Map_info | Map | IV | Position | 6.39518 | Error | 0.005633 | |||
| Positive | Positive_clone | ZK896 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (35) | |||||||||
| Remark | gcy-26 added as an other name following email from J. Hodgkin. gcy-26 gene object removed. 02/06/12 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
