WormBase Tree Display for Gene: WBGene00001516
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| WBGene00001516 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gap-2 | Person_evidence | WBPerson1160 | |||||
| Sequence_name | ZK899.8 | ||||||||
| Molecular_name (40) | |||||||||
| Other_name | CELE_ZK899.8 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | gap-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gap | ||||||||
| Allele (823) | |||||||||
| Legacy_information | [Iino Y] predicted gene product has sequence similarity to mammalian p120 ras GTPase activating protein. Predicted gene C07B5.1. pe103 and pe104 are Tc1-induced intragenic deletions. | ||||||||
| Strain | WBStrain00022685 | ||||||||
| WBStrain00035972 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00001515 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | gap-2 encodes a Ras GTPase-activating protein (RasGAP) that is orthologous to mammalian nGAP and synGAP (OMIM:606136, OMIM:603384, synGAP is essential for postnatal survival and neuronal development); by homology, GAP-2 is predicted to function as a negative regulator of Ras signaling by enhancing the intrinsically weak Ras GTPase activity; gap-2 loss-of-function mutations partially suppress the larval lethality of let-23 and let-60 loss-of-function mutations, supporting a role for gap-2 in negative regulation of Ras signaling in vivo; gap-2 can encode at least eight different isoforms that appear to be expressed in a wide variety of tissues including the vulva, gonad, pharynx, neurons, and blast/rectal cells of the tail. | Paper_evidence | WBPaper00003085 | |||||
| WBPaper00005245 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Jul 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTPase activator activity. Involved in learning or memory and negative regulation of Ras protein signal transduction. Predicted to be located in cytoplasm. Expressed in several structures, including head muscle; head neurons; non-striated muscle; tail; and vulva. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 5; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma. Is an ortholog of human DAB2IP (DAB2 interacting protein); RASAL2 (RAS protein activator like 2); and SYNGAP1 (synaptic Ras GTPase activating protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (16) | ||||||||
| Molecular_info | Corresponding_CDS (12) | ||||||||
| Corresponding_CDS_history | ZK899.8g:wp52 | ||||||||
| Corresponding_transcript (16) | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature (62) | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr82 | ||||||||
| Expr1486 | |||||||||
| Expr1487 | |||||||||
| Expr1018807 | |||||||||
| Expr1030912 | |||||||||
| Expr1163253 | |||||||||
| Expr2011942 | |||||||||
| Expr2030179 | |||||||||
| Drives_construct | WBCnstr00010299 | ||||||||
| Construct_product | WBCnstr00010299 | ||||||||
| Microarray_results (100) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (41) | |||||||||
| Map_info | Map | X | Position | 1.31883 | Error | 0.03563 | |||
| Positive | Positive_clone | C07B5 | Person_evidence | WBPerson284 | |||||
| ZK899 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4333 | |||||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | removing Cosmid C04D8 and sequence C04D8.1. [sdm 11/2000] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
