WormBase Tree Display for Gene: WBGene00001374
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| WBGene00001374 | SMap | S_parent | Sequence | F12F3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | exp-2 | Person_evidence | WBPerson655 | |||||
| Sequence_name | F12F3.1 | ||||||||
| Molecular_name (19) | |||||||||
| Other_name | CELE_F12F3.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | exp-2 | ||||||||
| DB_info | Database | AceView | gene | 5G623 | |||||
| WormQTL | gene | WBGene00001374 | |||||||
| WormFlux | gene | WBGene00001374 | |||||||
| NDB | locus_tag | CELE_F12F3.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001374|UniProtKB=H2KZQ6 | |||||||
| family | PTHR11537 | ||||||||
| NCBI | gene | 179003 | |||||||
| RefSeq | protein | NM_001380662.1 | |||||||
| NM_001028621.5 | |||||||||
| NM_001380661.1 | |||||||||
| NM_001392526.1 | |||||||||
| TrEMBL | UniProtAcc | Q5WRQ6 | |||||||
| H2KZQ6 | |||||||||
| P91256 | |||||||||
| H2KZQ7 | |||||||||
| UniProt_GCRP | UniProtAcc | H2KZQ6 | |||||||
| OMIM | gene | 600397 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | exp | ||||||||
| Allele (162) | |||||||||
| Legacy_information | [Jim Thomas] sa26/+ strongly dominant defecation and egg laying defective, expulsion muscle contraction (Exp) always absent from defecation cycle, severe egg laying defect (Egl), serotonin nonresponsive, egg laying and anal muscle normal as observed by polarized light, pumping very shallow but rapid, homozygous viable | ||||||||
| See also sa26 | |||||||||
| [Reiner D]] Mac-d (Muscle ACtivation-Defective) | |||||||||
| [C.elegansII] sa26sd : recessive viable; sa26/+ strongly dominant,severely constipated, jerky Unc;expulsion muscle contraction (Exp) always absent from defecation cycle, severe egg laying defect (Type A Egl), serotonin nonresponsive, egg laying and anal muscle normal as observed by polarized light, pumping very shallow but rapid. Muscle activation defective (flaccid, long). NA1 (gf).Intragenic revertants, eg sa26sa66, sa26sa68, arerecessive lethal, no dominant Exp phenotype. [Thomas 1990; JT] | |||||||||
| Strain | WBStrain00003004 | ||||||||
| WBStrain00022817 | |||||||||
| WBStrain00005574 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (44) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | exp-2 encodes a member of the six-transmembrane voltage-activated (Kv-type) family of potassium channels; exp-2 is required for normal pharyngeal muscle action potentials and hence, for normal feeding behavior; in addition, exp-2 is required for chemotaxis; when expressed in Xenopus oocytes, EXP-2 displays inward rectifying currents, however when assessed in endogenous pharyngeal tissue, EXP-2 displays hyperpolarization-activated outward currents; an EXP-2 translational reporter fusion is expressed strongly in pharyngeal muscles, amphid, phasmid, and head neurons, posterior enteric muscles, and occasionally faintly in the egg-laying muscles. | Paper_evidence | WBPaper00003840 | |||||
| WBPaper00025209 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Sep 2005 00:00:00 | ||||||||
| Automated_description | Enables inward rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Expressed in intestinal cell; muscle cell; nerve ring; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26. Is an ortholog of human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080461 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6231) | ||||
| DOID:1826 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6231) | ||||||
| Molecular_info | Corresponding_CDS | F12F3.1a | |||||||
| F12F3.1b | |||||||||
| F12F3.1c | |||||||||
| F12F3.1d | |||||||||
| Corresponding_CDS_history | F12F3.1:wp90 | ||||||||
| F12F3.1:wp131 | |||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence (27) | |||||||||
| Associated_feature | WBsf646857 | ||||||||
| WBsf1000179 | |||||||||
| WBsf1000180 | |||||||||
| WBsf1019738 | |||||||||
| WBsf1019739 | |||||||||
| WBsf231841 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00044446 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00090201 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090043 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013165 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089883 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089832 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1231 | ||||||||
| Expr1027 | |||||||||
| Expr12746 | |||||||||
| Expr1021455 | |||||||||
| Expr1030828 | |||||||||
| Expr1148393 | |||||||||
| Expr2011409 | |||||||||
| Expr2029645 | |||||||||
| Drives_construct | WBCnstr00003504 | ||||||||
| WBCnstr00010037 | |||||||||
| WBCnstr00036984 | |||||||||
| Construct_product | WBCnstr00010037 | ||||||||
| WBCnstr00022462 | |||||||||
| WBCnstr00022728 | |||||||||
| WBCnstr00036984 | |||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (175) | |||||||||
| Interaction (27) | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | V | Position | -0.262655 | Error | 0.010268 | |||
| Positive | Inside_rearr | adDf1059 | |||||||
| Positive_clone | F12F3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 4436 | |||||||
| 4581 | |||||||||
| Multi_point | 1533 | ||||||||
| 2270 | |||||||||
| 3122 | |||||||||
| 3550 | |||||||||
| 5324 | |||||||||
| Pos_neg_data (16) | |||||||||
| Reference (36) | |||||||||
| Method | Gene |
