WormBase Tree Display for Gene: WBGene00001374
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| WBGene00001374 | SMap | S_parent | Sequence | F12F3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | exp-2 | Person_evidence | WBPerson655 | |||||
| Sequence_name | F12F3.1 | ||||||||
| Molecular_name (19) | |||||||||
| Other_name | CELE_F12F3.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | exp-2 | ||||||||
| DB_info | Database | AceView | gene | 5G623 | |||||
| WormQTL | gene | WBGene00001374 | |||||||
| WormFlux | gene | WBGene00001374 | |||||||
| NDB | locus_tag | CELE_F12F3.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001374|UniProtKB=H2KZQ6 | |||||||
| family | PTHR11537 | ||||||||
| NCBI | gene | 179003 | |||||||
| RefSeq | protein | NM_001380662.1 | |||||||
| NM_001028621.5 | |||||||||
| NM_001380661.1 | |||||||||
| NM_001392526.1 | |||||||||
| TrEMBL | UniProtAcc | Q5WRQ6 | |||||||
| H2KZQ6 | |||||||||
| P91256 | |||||||||
| H2KZQ7 | |||||||||
| UniProt_GCRP | UniProtAcc | H2KZQ6 | |||||||
| OMIM | gene | 600397 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | exp | ||||||||
| Allele (162) | |||||||||
| Legacy_information (4) | |||||||||
| Strain | WBStrain00003004 | ||||||||
| WBStrain00022817 | |||||||||
| WBStrain00005574 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (44) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | exp-2 encodes a member of the six-transmembrane voltage-activated (Kv-type) family of potassium channels; exp-2 is required for normal pharyngeal muscle action potentials and hence, for normal feeding behavior; in addition, exp-2 is required for chemotaxis; when expressed in Xenopus oocytes, EXP-2 displays inward rectifying currents, however when assessed in endogenous pharyngeal tissue, EXP-2 displays hyperpolarization-activated outward currents; an EXP-2 translational reporter fusion is expressed strongly in pharyngeal muscles, amphid, phasmid, and head neurons, posterior enteric muscles, and occasionally faintly in the egg-laying muscles. | Paper_evidence | WBPaper00003840 | |||||
| WBPaper00025209 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Sep 2005 00:00:00 | ||||||||
| Automated_description | Enables inward rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Expressed in intestinal cell; muscle cell; nerve ring; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26. Is an ortholog of human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080461 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6231) | ||||
| DOID:1826 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6231) | ||||||
| Molecular_info | Corresponding_CDS | F12F3.1a | |||||||
| F12F3.1b | |||||||||
| F12F3.1c | |||||||||
| F12F3.1d | |||||||||
| Corresponding_CDS_history | F12F3.1:wp90 | ||||||||
| F12F3.1:wp131 | |||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence (27) | |||||||||
| Associated_feature | WBsf646857 | ||||||||
| WBsf1000179 | |||||||||
| WBsf1000180 | |||||||||
| WBsf1019738 | |||||||||
| WBsf1019739 | |||||||||
| WBsf231841 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00044446 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00090201 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090043 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013165 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089883 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089832 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1231 | ||||||||
| Expr1027 | |||||||||
| Expr12746 | |||||||||
| Expr1021455 | |||||||||
| Expr1030828 | |||||||||
| Expr1148393 | |||||||||
| Expr2011409 | |||||||||
| Expr2029645 | |||||||||
| Drives_construct | WBCnstr00003504 | ||||||||
| WBCnstr00010037 | |||||||||
| WBCnstr00036984 | |||||||||
| Construct_product | WBCnstr00010037 | ||||||||
| WBCnstr00022462 | |||||||||
| WBCnstr00022728 | |||||||||
| WBCnstr00036984 | |||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (175) | |||||||||
| Interaction (27) | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | V | Position | -0.262655 | Error | 0.010268 | |||
| Positive | Inside_rearr | adDf1059 | |||||||
| Positive_clone | F12F3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 4436 | |||||||
| 4581 | |||||||||
| Multi_point | 1533 | ||||||||
| 2270 | |||||||||
| 3122 | |||||||||
| 3550 | |||||||||
| 5324 | |||||||||
| Pos_neg_data (16) | |||||||||
| Reference (36) | |||||||||
| Method | Gene |
