WormBase Tree Display for Gene: WBGene00001333
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| WBGene00001333 | SMap | S_parent | Sequence | C01G8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | erm-1 | Person_evidence | WBPerson204 | |||||
| Sequence_name | C01G8.5 | ||||||||
| Molecular_name | C01G8.5a | ||||||||
| C01G8.5a.1 | |||||||||
| CE07805 | |||||||||
| C01G8.5b | |||||||||
| CE07806 | |||||||||
| C01G8.5b.1 | |||||||||
| Other_name | CELE_C01G8.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | erm-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | erm | ||||||||
| Allele (83) | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Contained_in_operon | CEOP1232 | ||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00003593 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WBGene00001488 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001489 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001491 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | erm-1 encodes the C. elegans ortholog of the ERM (Ezrin, Radixin, Moesin) family of cytoskeletal linkers; ERM-1 activity is required for regulating LET-23/EGFR receptor localization in the vulval cell lineages to effect proper temporal regulation of Ras-mediated EGF signaling. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00045219 | |||||||||
| Person_evidence | WBPerson204 | ||||||||
| Curator_confirmed | WBPerson13481 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 21 Aug 2014 00:00:00 | ||||||||
| Automated_description | Enables cytoskeletal anchor activity and structural molecule activity. Involved in several processes, including actin filament organization; nematode larval development; and protein localization to basolateral plasma membrane. Located in actin filament; apical part of cell; and membrane-enclosed lumen. Expressed in several structures, including PVD; excretory canal; germ line; germline precursor cell; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24 and immunodeficiency 50. Is an ortholog of human EZR (ezrin) and MSN (moesin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110482 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9944) | ||||
| DOID:0112001 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7373) | ||||||
| Molecular_info | Corresponding_CDS | C01G8.5a | |||||||
| C01G8.5b | |||||||||
| Corresponding_transcript | C01G8.5a.1 | ||||||||
| C01G8.5b.1 | |||||||||
| Other_sequence (99) | |||||||||
| Associated_feature (21) | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00002391 | ||||||||
| WBCnstr00004859 | |||||||||
| WBCnstr00009367 | |||||||||
| WBCnstr00011049 | |||||||||
| WBCnstr00016977 | |||||||||
| WBCnstr00017207 | |||||||||
| WBCnstr00017213 | |||||||||
| WBCnstr00017214 | |||||||||
| WBCnstr00019386 | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00000915 | ||||||||
| WBAntibody00000994 | |||||||||
| WBAntibody00001717 | |||||||||
| WBAntibody00002174 | |||||||||
| WBAntibody00002426 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (111) | |||||||||
| Interaction (113) | |||||||||
| Map_info | Map | I | Position | -0.159008 | Error | 0.004512 | |||
| Positive | Positive_clone | C01G8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4226 | |||||||
| Pseudo_map_position | |||||||||
| Reference (75) | |||||||||
| Remark | Gene info and sequence connections supplied by Verena Gobel [02/06/10 krb] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
