WormBase Tree Display for Gene: WBGene00001330

WBGene00001330 SMap: S_parent: Sequence: Y57G11C
  Identity: Version: 1
    Name: CGC_name: eps-8 Person_evidence: WBPerson52
      Sequence_name: Y57G11C.24
      Molecular_name (36)
      Other_name: gei-19 CGC_data_submission
        CELE_Y57G11C.24 Accession_evidence: NDB BX284604
      Public_name: eps-8
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: eps
    Allele (382)
    Strain: WBStrain00003266
      WBStrain00031465
      WBStrain00005395
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog: WBGene00034550 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00148685 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00070796 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
      WBGene00127589 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
      CBOVI.g8776 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g7403 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g1792 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7560 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g3426 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g15817 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g628 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g13710 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g25318 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g8042 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g5493 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00384.g10098 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_IV.g12386 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold584.g4739 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00815.g15724 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_15916 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_012841 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12343 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g3973 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40180900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g12553 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00182250 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00070794 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00079582 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00081300 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00081301 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00106314 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00266168 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00288864 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0029095 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            SonicParanoid
      FB:FBgn0038466 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-040426-871 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-040426-1335 Danio rerio From_analysis: OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-050306-14 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-050506-143 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-131121-340 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-091204-460 Danio rerio From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:3420 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:21295 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:21296 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:21297 Homo sapiens From_analysis: OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:104684 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1914675 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2138828 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2139743 Mus musculus From_analysis: OrthoFinder
            OrthoInspector
            Panther
      RGD:1308310 Rattus norvegicus From_analysis: OrthoFinder
            OrthoInspector
            Panther
      RGD:1310590 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1311146 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1310912 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Structured_description: Concise_description: eps-8 is encodes a cell signaling adaptor protein that contains and N-terminal PTB domain, and C-terminal SH3 and actin-binding domains; EPS-8 is essential for epidermal and intestinal cells morphogenesis; eps-8 is also involved in trafficking of the LET-23 EGF receptor during vulval development; EPS-8 physically interacts with the ankyrin repeat protein VAB-19 and demonstrates a novel actin barbed-end-capping activity; EPS-8 is expressed throughout development and localizes to sites of cell-matrix attachment and to the apical side of polarized cells. Paper_evidence: WBPaper00004651
            WBPaper00005194
            WBPaper00005654
            WBPaper00006395
            WBPaper00032444
            WBPaper00027626
            WBPaper00024614
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 29 Jan 2012 00:00:00
      Automated_description: Enables actin filament binding activity. Involved in several processes, including anatomical structure morphogenesis; barbed-end actin filament capping; and supramolecular fiber organization. Located in apical part of cell; brush border; and hemidesmosome. Expressed in several structures, including P3.pa; P3.pp; P5.ppp; P7.paa; and P9.p. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102; autosomal recessive nonsyndromic deafness 106; and hypotrichosis 5. Is an ortholog of human EPS8L1 (EPS8 signaling adaptor L1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (3)
  Molecular_info: Corresponding_CDS (12)
    Corresponding_CDS_history: Y57G11C.24a:wp107
      Y57G11C.24a:wp151
      Y57G11C.24b:wp151
      Y57G11C.24c:wp107
      Y57G11C.24c:wp151
      Y57G11C.24d:wp151
      Y57G11C.24e:wp151
    Corresponding_transcript (12)
    Other_sequence (45)
    Associated_feature (20)
  Experimental_info: RNAi_result (27)
    Expr_pattern (12)
    Drives_construct: WBCnstr00003741
      WBCnstr00005193
      WBCnstr00005431
      WBCnstr00011220
    Construct_product: WBCnstr00005192
      WBCnstr00005432
      WBCnstr00011220
    Antibody: WBAntibody00000805
      WBAntibody00000806
    Microarray_results (64)
    Expression_cluster (202)
    SAGE_tag: SAGE:caacaacaac Strand: Sense
        Unambiguously_mapped
      SAGE:gtccaggtgg Strand: Antisense
      SAGE:ttcccggcgg Strand: Antisense
      SAGE:caacaacaacaacagca Strand: Sense
        Unambiguously_mapped
    Interaction (109)
  Map_info: Map: IV Position: 12.6052 Error: 0.00069
    Positive: Positive_clone: Y57G11C Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4235
        4290
    Pseudo_map_position
  Reference (24)
  Remark: gei-19 has been merged into the eps-8 gene following advice from the CGC [krb 030902]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene