WormBase Tree Display for Gene: WBGene00001330
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| WBGene00001330 | SMap | S_parent | Sequence | Y57G11C | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | eps-8 | Person_evidence | WBPerson52 | |||||
| Sequence_name | Y57G11C.24 | ||||||||
| Molecular_name (36) | |||||||||
| Other_name | gei-19 | CGC_data_submission | |||||||
| CELE_Y57G11C.24 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | eps-8 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | eps | ||||||||
| Allele (382) | |||||||||
| Strain | WBStrain00003266 | ||||||||
| WBStrain00031465 | |||||||||
| WBStrain00005395 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00000080 | ||||||||
| 00000081 | |||||||||
| 00000082 | |||||||||
| 00000083 | |||||||||
| 00000084 | |||||||||
| 00013091 | |||||||||
| 00013092 | |||||||||
| 00013093 | |||||||||
| 00013094 | |||||||||
| 00013095 | |||||||||
| 00013096 | |||||||||
| 00013097 | |||||||||
| 00013098 | |||||||||
| 00013099 | |||||||||
| 00013100 | |||||||||
| 00013101 | |||||||||
| 00013102 | |||||||||
| 00013103 | |||||||||
| 00013104 | |||||||||
| 00013105 | |||||||||
| 00013106 | |||||||||
| 00013107 | |||||||||
| 00013108 | |||||||||
| 00013109 | |||||||||
| 00013110 | |||||||||
| 00013111 | |||||||||
| 00013112 | |||||||||
| 00013113 | |||||||||
| 00013114 | |||||||||
| 00013115 | |||||||||
| 00013116 | |||||||||
| 00013117 | |||||||||
| Ortholog (53) | |||||||||
| Structured_description | Concise_description | eps-8 is encodes a cell signaling adaptor protein that contains and N-terminal PTB domain, and C-terminal SH3 and actin-binding domains; EPS-8 is essential for epidermal and intestinal cells morphogenesis; eps-8 is also involved in trafficking of the LET-23 EGF receptor during vulval development; EPS-8 physically interacts with the ankyrin repeat protein VAB-19 and demonstrates a novel actin barbed-end-capping activity; EPS-8 is expressed throughout development and localizes to sites of cell-matrix attachment and to the apical side of polarized cells. | Paper_evidence | WBPaper00004651 | |||||
| WBPaper00005194 | |||||||||
| WBPaper00005654 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00032444 | |||||||||
| WBPaper00027626 | |||||||||
| WBPaper00024614 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 29 Jan 2012 00:00:00 | ||||||||
| Automated_description | Enables actin filament binding activity. Involved in several processes, including anatomical structure morphogenesis; barbed-end actin filament capping; and supramolecular fiber organization. Located in apical part of cell; brush border; and hemidesmosome. Expressed in several structures, including P3.pa; P3.pp; P5.ppp; P7.paa; and P9.p. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102; autosomal recessive nonsyndromic deafness 106; and hypotrichosis 5. Is an ortholog of human EPS8L1 (EPS8 signaling adaptor L1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21296) | ||||
| DOID:0110463 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3420) | ||||||
| DOID:0110702 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21297) | ||||||
| Molecular_info | Corresponding_CDS (12) | ||||||||
| Corresponding_CDS_history | Y57G11C.24a:wp107 | ||||||||
| Y57G11C.24a:wp151 | |||||||||
| Y57G11C.24b:wp151 | |||||||||
| Y57G11C.24c:wp107 | |||||||||
| Y57G11C.24c:wp151 | |||||||||
| Y57G11C.24d:wp151 | |||||||||
| Y57G11C.24e:wp151 | |||||||||
| Corresponding_transcript (12) | |||||||||
| Other_sequence (45) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result (27) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00003741 | ||||||||
| WBCnstr00005193 | |||||||||
| WBCnstr00005431 | |||||||||
| WBCnstr00011220 | |||||||||
| Construct_product | WBCnstr00005192 | ||||||||
| WBCnstr00005432 | |||||||||
| WBCnstr00011220 | |||||||||
| Antibody | WBAntibody00000805 | ||||||||
| WBAntibody00000806 | |||||||||
| Microarray_results (64) | |||||||||
| Expression_cluster (202) | |||||||||
| SAGE_tag | SAGE:caacaacaac | Strand | Sense | ||||||
| Unambiguously_mapped | |||||||||
| SAGE:gtccaggtgg | Strand | Antisense | |||||||
| SAGE:ttcccggcgg | Strand | Antisense | |||||||
| SAGE:caacaacaacaacagca | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| Interaction (109) | |||||||||
| Map_info | Map | IV | Position | 12.6052 | Error | 0.00069 | |||
| Positive | Positive_clone | Y57G11C | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4235 | |||||||
| 4290 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (24) | |||||||||
| Remark | gei-19 has been merged into the eps-8 gene following advice from the CGC [krb 030902] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
