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WormBase Tree Display for Gene: WBGene00001309

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Name Class

WBGene00001309SMapS_parentSequenceM01D7
IdentityVersion1
NameCGC_nameemr-1
Sequence_nameM01D7.6
Molecular_nameM01D7.6
M01D7.6.1
CE12270
M01D7.6.2
Other_nameCELE_M01D7.6Accession_evidenceNDBBX284601
Public_nameemr-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classemr
Allele (18)
StrainWBStrain00002843
WBStrain00035605
WBStrain00036376
WBStrain00003842
RNASeq_FPKM (74)
GO_annotation (14)
Contained_in_operonCEOP1992
Ortholog (12)
Structured_descriptionConcise_descriptionemr-1 gene encodes a homolog of the human integral nuclear membrane protein emerin ; EMR-1 belongs to a family of proteins sharing the LEM-domain (LAP2-Emerin-MAN1 domain) that are generally conserved in metazoa and bind to lamin; EMR-1, along with another LEM-domain protein, LEM-2 is required for larval development, normal life-span, nuclear envelope and chromatin organization, chromosome segregation and cell division; emr-1 is also required for smooth muscle activity; emr-1 negatively regulates pha-4, the transcription factor required for pharynx identity; EMR-1 protein is found in the nuclear envelopes of all cell types except sperm and at all life stages; EMR-1 binds to lamin/LMN-1; emr-1 mutations also exhibit weak hypersensitivity to DNA damage.Paper_evidenceWBPaper00004339
WBPaper00005158
WBPaper00005648
WBPaper00005828
WBPaper00040518
WBPaper00037040
WBPaper00040826
Curator_confirmedWBPerson48
WBPerson1843
WBPerson324
WBPerson567
Date_last_updated12 Apr 2012 00:00:00
Automated_descriptionEnables lamin binding activity. Involved in several processes, including mitotic cytokinesis; nuclear envelope organization; and response to X-ray. Located in nuclear inner membrane. Used to study Emery-Dreifuss muscular dystrophy. Is an ortholog of human LEMD1 (LEM domain containing 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:11726Homo sapiensPaper_evidenceWBPaper00044786
Accession_evidenceOMIM181350
Curator_confirmedWBPerson324
Date_last_updated09 Oct 2017 00:00:00
Disease_relevanceMutations in the human ortholog of emr-1, emerin, cause X-linked Emery-Dreifuss muscular dystrophy (EDMD); Emerin is a nuclear lamina protein and belongs to a family of LEM (LAP2-Emerin-MAN1) domain proteins that include MAN1, LEM2/NET25 and several others; LEM domain proteins bind lamin; mutations in human LMNA/lamin cause several laminopathic diseases including EDMD; much of the knowledge of the organization and assembly of the nuclear lamina has come from studies in elegans; studies in elegans have demonstrated the overlapping roles of emerin and lem-2 in embryogenesis, cell proliferation, lamin and heterochromatin organization; worm emerin and lem-2 are also involved in mitosis, smooth and striated muscle function, lifespan and meiotic progression, pointing to the many underlying processes that may affect disease phenotypes.Homo sapiensPaper_evidenceWBPaper00040268
Accession_evidenceOMIM310300
300384
Curator_confirmedWBPerson324
Date_last_updated01 Mar 2012 00:00:00
Models_disease_assertedWBDOannot00000045
Molecular_infoCorresponding_CDSM01D7.6
Corresponding_transcriptM01D7.6.1
M01D7.6.2
Other_sequenceGRC02002_1
GPC01900_1
CRC09112_1
CR02292
GP02519
CBC09681_1
Associated_featureWBsf982768
WBsf982769
WBsf217259
Experimental_infoRNAi_result (12)
Expr_pattern (13)
Drives_constructWBCnstr00000686
WBCnstr00000688
WBCnstr00003365
WBCnstr00018932
WBCnstr00020603
WBCnstr00020604
WBCnstr00020605
WBCnstr00037001
Construct_product (11)
Regulate_expr_clusterWBPaper00044786:emr-1(gk119)_downregulated
WBPaper00044786:emr-1(gk119)_upregulated
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
AntibodyWBAntibody00000305
WBAntibody00000306
WBAntibody00000307
WBAntibody00000597
WBAntibody00001856
WBAntibody00001941
Microarray_results (22)
Expression_cluster (149)
InteractionWBInteraction000135515
WBInteraction000135558
WBInteraction000160390
WBInteraction000160931
WBInteraction000180924
WBInteraction000196963
WBInteraction000203134
WBInteraction000203436
WBInteraction000219143
WBInteraction000224213
WBInteraction000227338
WBInteraction000230080
WBInteraction000234100
WBInteraction000247368
WBInteraction000255193
WBInteraction000255740
WBInteraction000256181
WBInteraction000273807
WBInteraction000274146
WBInteraction000288309
WBInteraction000292054
WBInteraction000295997
WBInteraction000302418
WBInteraction000309437
WBInteraction000330907
WBInteraction000335379
WBInteraction000346944
WBInteraction000348675
WBInteraction000349467
WBInteraction000357212
WBInteraction000363647
WBInteraction000367547
WBInteraction000368533
WBInteraction000375794
WBInteraction000376550
WBInteraction000378679
WBInteraction000381686
WBInteraction000386071
WBInteraction000402752
WBInteraction000414396
WBInteraction000416781
WBInteraction000417582
WBInteraction000419713
WBInteraction000421041
WBInteraction000425809
WBInteraction000436998
WBInteraction000440249
WBInteraction000441437
WBInteraction000441770
WBInteraction000442530
WBInteraction000443255
WBInteraction000443459
WBInteraction000446581
WBInteraction000447655
WBInteraction000452200
WBInteraction000462298
WBInteraction000501383
WBInteraction000502596
WBInteraction000505178
WBInteraction000544761
WBInteraction000544762
WBInteraction000544763
WBInteraction000550335
WBInteraction000551386
WBInteraction000551387
WBInteraction000554774
WBInteraction000556734
WBInteraction000557551
WBInteraction000557988
WBInteraction000557989
WBInteraction000557990
WBInteraction000557991
WBInteraction000557992
WBInteraction000557993
WBInteraction000559397
WBInteraction000569490
WBInteraction000569491
WBInteraction000570744
WBInteraction000573415
WBInteraction000578868
WBInteraction000578870
WBInteraction000579028
WBInteraction000579029
WBInteraction000581980
Map_info (4)
Reference (35)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene