WormBase Tree Display for Interaction: WBInteraction000557991
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| WBInteraction000557991 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003795 | Interactor_type | Trans_regulator | |
| WBGene00001309 | Interactor_type | Trans_regulated | |||
| Interaction_summary | "In embryos depleted of Ran or any of its cofactors, RanBP2, RanGAP, or RCC1, no NE-like GFP::EMR-1 signal was detected after the first cell division in the majority of cases (67%) (Figure 8, B and D-F, Video 13). In other embryos, presumably where the RNAi had been less efficient, aberrant nuclei with a strong aggregation of GFP::EMR-1 next to the NE became apparent after a prolonged time (Figure 8C)... Embryos depleted of IMB-1 showed a strong defect in GFP::EMR-1 recruitment to the NE-like structures after mitosis (Figure 7H and Video16, 3 of 3 embryos). As with embryos where Ran or its cofactors had been targeted, imb-1(RNAi) embryos instead showed clustering of GFP::EMR-1 at the centrosomes." | ||||
| Detection_method | Reporter_gene | [EMR-1::GFP] | |||
| Regulation_level | Post_translational | ||||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000003 | ||
| Subcellular_localization | nuclear envelope | ||||
| Paper | WBPaper00005637 | ||||
| Remark | Fig. 8 |
