WormBase Tree Display for Gene: WBGene00001076

WBGene00001076 Evidence: Person_evidence: WBPerson261
      WBPerson2629
  SMap: S_parent: Sequence: F54D8
  Identity: Version: 2
    Name: CGC_name: dpy-17 Person_evidence: WBPerson261
      Sequence_name: F54D8.1
      Molecular_name: F54D8.1
        F54D8.1.1
        CE11066
      Other_name: CELE_F54D8.1 Accession_evidence: NDB BX284603
      Public_name: dpy-17
    DB_info: Database: AceView gene 3G197
        WormQTL gene WBGene00001076
        WormFlux gene WBGene00001076
        NDB locus_tag CELE_F54D8.1
        Panther gene CAEEL|WormBase=WBGene00001076|UniProtKB=Q20778
          family PTHR24637
        NCBI gene 175696
        RefSeq protein NM_065685.9
        TREEFAM TREEFAM_ID TF321978
        TrEMBL UniProtAcc Q20778
        UniProt_GCRP UniProtAcc Q20778
    Species: Caenorhabditis elegans
    History: Version_change: 1 02 Jul 2004 16:55:45 WBPerson1845 Event: Created
        2 02 Jul 2004 16:42:33 WBPerson1971 Event: Acquires_merge: WBGene00018799
      Acquires_merge: WBGene00018799
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dpy
    Reference_allele: WBVar00143004
    Allele (28)
    Legacy_information: e164 : medium dumpy spindle-shaped adult; old adults sometimes less dumpy; strong dumpy L1. ES3 (all stages). ME2. NA7 (e1345ts e905pdi e1295icr etc.).
      See also e164, e417, e2145
      [C.elegansII] e164 : medium dumpy, spindle-shaped adult; old adults sometimes less dumpy; strong dumpy L1; low penetrance defects in outgrowth of posterior canal cell processes. ES3 (all stages). ME2. OA6: e1345ts, e905pdi, e1295icr, e1345, e2145 etc. [Brenner 1974; NJ]
    Strain (204)
    RNASeq_FPKM (74)
    GO_annotation: 00069103
      00069104
      00069105
      00108198
    Ortholog (29)
    Paralog (161)
    Structured_description: Concise_description: dpy-17 encodes a cuticle collagen; during development, dpy-17 activity is required for normal body morphology, hermaphrodite tail development, and outgrowth of posterior canal cell processes; genetic and immunofluorescence studies suggest that extracellular assembly of DPY-17 and the essential SQT-3 cuticle collagen is interdependent, as loss of dpy-17 activity results in intracellular retention of SQT-3 and dpy-17(gf) mutations suppress mutations in dpy-31, which encodes a zinc-metalloprotease predicted to affect C-terminal proteolytic maturation of SQT-3. Paper_evidence: WBPaper00000031
            WBPaper00005485
            WBPaper00027067
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 08 Aug 2006 00:00:00
      Automated_description: Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be part of collagen trimer. Used to study Marfan syndrome. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14323 Homo sapiens Paper_evidence: WBPaper00046710
          Curator_confirmed: WBPerson324
          Date_last_updated: 25 Sep 2015 00:00:00
  Models_disease_in_annotation: WBDOannot00000379
  Molecular_info: Corresponding_CDS: F54D8.1
    Corresponding_transcript: F54D8.1.1
    Other_sequence (37)
    Associated_feature: WBsf645149
      WBsf645150
      WBsf658889
      WBsf658890
      WBsf658891
      WBsf658892
      WBsf658893
      WBsf658894
      WBsf224863
  Experimental_info: RNAi_result: WBRNAi00073110 Inferred_automatically: RNAi_primary
      WBRNAi00002433 Inferred_automatically: RNAi_primary
      WBRNAi00073111 Inferred_automatically: RNAi_primary
      WBRNAi00025629 Inferred_automatically: RNAi_primary
      WBRNAi00048322 Inferred_automatically: RNAi_primary
      WBRNAi00048323 Inferred_automatically: RNAi_primary
      WBRNAi00002758 Inferred_automatically: RNAi_primary
      WBRNAi00032800 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr13628
      Expr1018849
      Expr1030684
      Expr1152124
      Expr2011059
      Expr2029296
    Drives_construct: WBCnstr00000440
      WBCnstr00037096
      WBCnstr00039888
    Construct_product: WBCnstr00000440
      WBCnstr00037096
    Microarray_results (19)
    Expression_cluster (311)
    Interaction (64)
    WBProcess: WBbiopr:00000124
  Map_info: Map: III Position: -2.13512 Error: 0.005986
    Well_ordered
    Positive: Inside_rearr: nDp2
        mT1
        ctDp11
      Positive_clone: F54D8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point (41)
      Multi_point (244)
      Pos_neg_data: 1578
        1582
        1586
        1596
        1616
        3244
        4711
        5141
        8706
  Reference (119)
  Remark: [Smardon A] dpy-17(e164) rescued by sEx271 [F54D8 + pCes1943{rol-6(su1006dm)}]. F54D8.1 encodes predicted protein with C-term similarity to sqt-1 collagen, therefore candidate for dpy-17.
  Method: Gene