WormBase Tree Display for Gene: WBGene00001076
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WBGene00001076 | Evidence | Person_evidence | WBPerson261 | ||||
---|---|---|---|---|---|---|---|
WBPerson2629 | |||||||
SMap | S_parent | Sequence | F54D8 | ||||
Identity | Version | 2 | |||||
Name | CGC_name | dpy-17 | Person_evidence | WBPerson261 | |||
Sequence_name | F54D8.1 | ||||||
Molecular_name | F54D8.1 | ||||||
F54D8.1.1 | |||||||
CE11066 | |||||||
Other_name | CELE_F54D8.1 | Accession_evidence | NDB | BX284603 | |||
Public_name | dpy-17 | ||||||
DB_info | Database | AceView | gene | 3G197 | |||
WormQTL | gene | WBGene00001076 | |||||
WormFlux | gene | WBGene00001076 | |||||
NDB | locus_tag | CELE_F54D8.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00001076|UniProtKB=Q20778 | |||||
family | PTHR24637 | ||||||
NCBI | gene | 175696 | |||||
RefSeq | protein | NM_065685.9 | |||||
TREEFAM | TREEFAM_ID | TF321978 | |||||
TrEMBL | UniProtAcc | Q20778 | |||||
UniProt_GCRP | UniProtAcc | Q20778 | |||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | dpy | ||||||
Reference_allele | WBVar00143004 | ||||||
Allele (28) | |||||||
Legacy_information | e164 : medium dumpy spindle-shaped adult; old adults sometimes less dumpy; strong dumpy L1. ES3 (all stages). ME2. NA7 (e1345ts e905pdi e1295icr etc.). | ||||||
See also e164, e417, e2145 | |||||||
[C.elegansII] e164 : medium dumpy, spindle-shaped adult; old adults sometimes less dumpy; strong dumpy L1; low penetrance defects in outgrowth of posterior canal cell processes. ES3 (all stages). ME2. OA6: e1345ts, e905pdi, e1295icr, e1345, e2145 etc. [Brenner 1974; NJ] | |||||||
Strain (204) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00069103 | ||||||
00069104 | |||||||
00069105 | |||||||
00108198 | |||||||
Ortholog (29) | |||||||
Paralog (161) | |||||||
Structured_description | Concise_description | dpy-17 encodes a cuticle collagen; during development, dpy-17 activity is required for normal body morphology, hermaphrodite tail development, and outgrowth of posterior canal cell processes; genetic and immunofluorescence studies suggest that extracellular assembly of DPY-17 and the essential SQT-3 cuticle collagen is interdependent, as loss of dpy-17 activity results in intracellular retention of SQT-3 and dpy-17(gf) mutations suppress mutations in dpy-31, which encodes a zinc-metalloprotease predicted to affect C-terminal proteolytic maturation of SQT-3. | Paper_evidence | WBPaper00000031 | |||
WBPaper00005485 | |||||||
WBPaper00027067 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson1843 | |||||||
Date_last_updated | 08 Aug 2006 00:00:00 | ||||||
Automated_description | Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be part of collagen trimer. Used to study Marfan syndrome. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:14323 | Homo sapiens | Paper_evidence | WBPaper00046710 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 25 Sep 2015 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000379 | ||||||
Molecular_info | Corresponding_CDS | F54D8.1 | |||||
Corresponding_transcript | F54D8.1.1 | ||||||
Other_sequence (37) | |||||||
Associated_feature | WBsf645149 | ||||||
WBsf645150 | |||||||
WBsf658889 | |||||||
WBsf658890 | |||||||
WBsf658891 | |||||||
WBsf658892 | |||||||
WBsf658893 | |||||||
WBsf658894 | |||||||
WBsf224863 | |||||||
Experimental_info | RNAi_result | WBRNAi00073110 | Inferred_automatically | RNAi_primary | |||
WBRNAi00002433 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00073111 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00025629 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00048322 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00048323 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00002758 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00032800 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr13628 | ||||||
Expr1018849 | |||||||
Expr1030684 | |||||||
Expr1152124 | |||||||
Expr2011059 | |||||||
Expr2029296 | |||||||
Drives_construct | WBCnstr00000440 | ||||||
WBCnstr00037096 | |||||||
WBCnstr00039888 | |||||||
Construct_product | WBCnstr00000440 | ||||||
WBCnstr00037096 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (311) | |||||||
Interaction (64) | |||||||
WBProcess | WBbiopr:00000124 | ||||||
Map_info | Map | III | Position | -2.13512 | Error | 0.005986 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDp2 | |||||
mT1 | |||||||
ctDp11 | |||||||
Positive_clone | F54D8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Mapping_data | 2_point (41) | ||||||
Multi_point (244) | |||||||
Pos_neg_data | 1578 | ||||||
1582 | |||||||
1586 | |||||||
1596 | |||||||
1616 | |||||||
3244 | |||||||
4711 | |||||||
5141 | |||||||
8706 | |||||||
Reference (119) | |||||||
Remark | [Smardon A] dpy-17(e164) rescued by sEx271 [F54D8 + pCes1943{rol-6(su1006dm)}]. F54D8.1 encodes predicted protein with C-term similarity to sqt-1 collagen, therefore candidate for dpy-17. | ||||||
Method | Gene |