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WormBase Tree Display for Gene: WBGene00001017

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Name Class

WBGene00001017SMapS_parentSequenceZK593
IdentityVersion1
NameCGC_namednc-1Person_evidenceWBPerson689
Sequence_nameZK593.5
Molecular_name (15)
Other_nameCELE_ZK593.5Accession_evidenceNDBBX284604
Public_namednc-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:22WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdnc
Allele (77)
Possibly_affected_byWBVar02153206
StrainWBStrain00007336
WBStrain00007349
WBStrain00024321
RNASeq_FPKM (74)
GO_annotation (35)
Ortholog (40)
ParalogWBGene00009987Caenorhabditis elegansFrom_analysisPanther
WBGene00010796Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptiondnc-1 encodes the C. elegans ortholog of the dynactin complex subunit p150/GLUED/DCTN1; dnc-1 is required for pronuclear migration and centrosome separation in one-cell embryos and for the correct alignment of mitotic spindles in early embryos; DNC-1 shares embryonic functions with DNC-2, DHC-1, LIS-1 and NUD-1; DNC-1 is part of the multisubunit dynactin complex in vivo, and physically interacts specifically with the DNC-2 and DNC-3 dynactin subunits; DNC-1 is located at cortical microtubule attachment sites.Paper_evidenceWBPaper00003225
WBPaper00003704
WBPaper00004895
WBPaper00018056
WBPaper00037699
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated08 Aug 2012 00:00:00
Automated_descriptionPredicted to enable dynein intermediate chain binding activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; regulation of dendrite morphogenesis; and single fertilization. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Part of dynactin complex. Expressed in AB; P0; and Psub1. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is an ortholog of human DCTN1 (dynactin subunit 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0060486Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2711)
DOID:0111202Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2711)
DOID:0060193Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2711)
Molecular_infoCorresponding_CDSZK593.5a
ZK593.5b
ZK593.5c
ZK593.5d
ZK593.5e
Corresponding_CDS_historyZK593.5:wp78
Corresponding_transcriptZK593.5a.1
ZK593.5b.1
ZK593.5c.1
ZK593.5d.1
ZK593.5e.1
Other_sequence (13)
Associated_feature (12)
Experimental_infoRNAi_result (28)
Expr_patternExpr1254
Expr9603
Expr15122
Expr1016044
Expr1030631
Expr1162944
Expr2010978
Expr2029216
Drives_constructWBCnstr00037141
Construct_productWBCnstr00001381
WBCnstr00007598
WBCnstr00037141
AntibodyWBAntibody00000192
WBAntibody00001320
WBAntibody00001493
WBAntibody00002751
Microarray_results (25)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044857:BAR-1_downregulated
WBPaper00045521:Gender_Neutral
WBPaper00046691:AB_enriched
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055648:germline_expressed
WBPaper00056275:P.aeruginosa_upregulated
WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
WBPaper00057288:Cold_downregulated_protein
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:sin-3(tm1276)_upregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
WBPaper00059471:EGL-43_interacting
WBPaper00059754:E.faecalis_OG1RF_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00061274:hypergravity_15xg_upregulated
WBPaper00061340:Neuroblast_ASJ_AUA
WBPaper00061340:Parents_of_U_F_B_DVA
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:klp-12-F10C2.5
WBPaper00061527:mtr-4_1623-W03F9.10_103
WBPaper00061527:utx-1_2886-swan-1_2192
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062554:MAGU-2_interacting
WBPaper00064992:Capsaicin_downregulated
WBPaper00064992:Eugenol_downregulated
WBPaper00064992:heat-shock_upregulated
WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066062:xrep-4(lax137)_upregulated
cgc4386_cluster_6_2
WBPaper00005124:testosterone_10-9M_regulated
WBPaper00025032:cluster_119
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030839:Embryo_A_Class
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00032165:A_to_C_transit_increased
WBPaper00032165:differentially_expressed_with_age_medoid_1
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_H
WBPaper00040823:alg-1(gk214)_downregulated
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00045960:L4-lethargus_downregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00053688:E.faecalis_upregulated
WBPaper00053688:E.faecium_upregulated
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(41_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:herm_sex-enriched
Interaction (183)
Map_infoMapIVPosition4.75022Error0.003469
PositivePositive_cloneZK593Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4263
5510
Pseudo_map_position
Reference (61)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene