WormBase Tree Display for Gene: WBGene00001017
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| WBGene00001017 | SMap | S_parent | Sequence | ZK593 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dnc-1 | Person_evidence | WBPerson689 | |||||
| Sequence_name | ZK593.5 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_ZK593.5 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | dnc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dnc | ||||||||
| Allele (77) | |||||||||
| Possibly_affected_by | WBVar02153206 | ||||||||
| Strain | WBStrain00007336 | ||||||||
| WBStrain00007349 | |||||||||
| WBStrain00024321 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00009987 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00010796 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | dnc-1 encodes the C. elegans ortholog of the dynactin complex subunit p150/GLUED/DCTN1; dnc-1 is required for pronuclear migration and centrosome separation in one-cell embryos and for the correct alignment of mitotic spindles in early embryos; DNC-1 shares embryonic functions with DNC-2, DHC-1, LIS-1 and NUD-1; DNC-1 is part of the multisubunit dynactin complex in vivo, and physically interacts specifically with the DNC-2 and DNC-3 dynactin subunits; DNC-1 is located at cortical microtubule attachment sites. | Paper_evidence | WBPaper00003225 | |||||
| WBPaper00003704 | |||||||||
| WBPaper00004895 | |||||||||
| WBPaper00018056 | |||||||||
| WBPaper00037699 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 08 Aug 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable dynein intermediate chain binding activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; regulation of dendrite morphogenesis; and single fertilization. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Part of dynactin complex. Expressed in AB; P0; and Psub1. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is an ortholog of human DCTN1 (dynactin subunit 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060486 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2711) | ||||
| DOID:0111202 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2711) | ||||||
| DOID:0060193 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2711) | ||||||
| Molecular_info | Corresponding_CDS | ZK593.5a | |||||||
| ZK593.5b | |||||||||
| ZK593.5c | |||||||||
| ZK593.5d | |||||||||
| ZK593.5e | |||||||||
| Corresponding_CDS_history | ZK593.5:wp78 | ||||||||
| Corresponding_transcript | ZK593.5a.1 | ||||||||
| ZK593.5b.1 | |||||||||
| ZK593.5c.1 | |||||||||
| ZK593.5d.1 | |||||||||
| ZK593.5e.1 | |||||||||
| Other_sequence (13) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern | Expr1254 | ||||||||
| Expr9603 | |||||||||
| Expr15122 | |||||||||
| Expr1016044 | |||||||||
| Expr1030631 | |||||||||
| Expr1162944 | |||||||||
| Expr2010978 | |||||||||
| Expr2029216 | |||||||||
| Drives_construct | WBCnstr00037141 | ||||||||
| Construct_product | WBCnstr00001381 | ||||||||
| WBCnstr00007598 | |||||||||
| WBCnstr00037141 | |||||||||
| Antibody | WBAntibody00000192 | ||||||||
| WBAntibody00001320 | |||||||||
| WBAntibody00001493 | |||||||||
| WBAntibody00002751 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (109) | |||||||||
| Interaction (183) | |||||||||
| Map_info | Map | IV | Position | 4.75022 | Error | 0.003469 | |||
| Positive | Positive_clone | ZK593 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4263 | |||||||
| 5510 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (61) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
