| WBGene00000950 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | deg-1 | Person_evidence | WBPerson95 |
| | | Sequence_name | C47C12.6 |
| | | Molecular_name | C47C12.6a |
| | | | C47C12.6a.1 |
| | | | CE24854 |
| | | | C47C12.6b |
| | | | CE53132 |
| | | | C47C12.6c |
| | | | CE53419 |
| | | | C47C12.6d |
| | | | CE53206 |
| | | | C47C12.6e |
| | | | CE53486 |
| | | | C47C12.6f |
| | | | CE53220 |
| | | | C47C12.6g |
| | | | CE53144 |
| | | | C47C12.6a.2 |
| | | | C47C12.6b.1 |
| | | | C47C12.6c.1 |
| | | | C47C12.6d.1 |
| | | | C47C12.6e.1 |
| | | | C47C12.6f.1 |
| | | | C47C12.6g.1 |
| | | Other_name | CELE_C47C12.6 | Accession_evidence | NDB | BX284606 |
| | | Public_name | deg-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 20 May 2019 15:21:47 | WBPerson4025 | Event | Acquires_merge | WBGene00016736 |
| | | Acquires_merge | WBGene00016736 |
| | Status | Live |
| Gene_info (12) |
| Disease_info | Experimental_model | DOID:1289 | Homo sapiens | Paper_evidence | WBPaper00001299 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 24 Aug 2018 00:00:00 |
| | | DOID:14452 | Homo sapiens | Paper_evidence | WBPaper00002711 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 24 Aug 2018 00:00:00 |
| | Potential_model | DOID:0080526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10600) |
| | | DOID:0050477 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10600,HGNC:10602) |
| | | DOID:4479 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10600,HGNC:10602) |
| | | DOID:0080528 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10602) |
| | Disease_relevance | C. elegans mec-4 and deg-1 genes encode proteins, called degenerins, that are similar to the subunits of the human amiloride-sensitive epithelial sodium-channels; death-inducing substitutions in the gain-of-function mutant deg-1, e1611 and u231, may hyperactivate the channels, resulting in increased or altered ion flow and/osmotic imbalance and consequent neuron death; similarities between the degenerin-induced deaths and the early pathology of of neurons in human dominant myotonias, excitotoxicity, and epilepsy suggest similar mechanisms; studies with the elegans mutations show that the abnormalities infolding of the plasma membrane whorls, cytoplasmic vacuoles, cell swelling, chromatin aggregates and nuclear invaginations; mitochondria and golgi are not dramatically affected until the final stages of cell death when organelles, and sometimes the cells lyse; pathology of degeneration is dependent on abnormal degenerin gene dosage. | Homo sapiens | Paper_evidence | WBPaper00002711 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 13 Nov 2014 00:00:00 |
| Models_disease_asserted | WBDOannot00000326 |
| | WBDOannot00000327 |
| | WBDOannot00000606 |
| | WBDOannot00000607 |
| | WBDOannot00000608 |
| Molecular_info | Corresponding_CDS | C47C12.6a |
| | | C47C12.6b |
| | | C47C12.6c |
| | | C47C12.6d |
| | | C47C12.6e |
| | | C47C12.6f |
| | | C47C12.6g |
| | Corresponding_transcript | C47C12.6a.1 |
| | | C47C12.6a.2 |
| | | C47C12.6b.1 |
| | | C47C12.6c.1 |
| | | C47C12.6d.1 |
| | | C47C12.6e.1 |
| | | C47C12.6f.1 |
| | | C47C12.6g.1 |
| | Other_sequence (23) |
| | Associated_feature | WBsf1005947 |
| | | WBsf1023306 |
| | | WBsf235973 |
| | | WBsf235974 |
| | | WBsf235975 |
| Experimental_info | RNAi_result | WBRNAi00012066 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00042661 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00042658 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00012062 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00012061 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr223 |
| | | Expr1018755 |
| | | Expr1024786 |
| | | Expr1030590 |
| | | Expr1146645 |
| | | Expr1146648 |
| | | Expr2001706 |
| | | Expr2010843 |
| | | Expr2019933 |
| | | Expr2029081 |
| | Drives_construct | WBCnstr00004791 |
| | | WBCnstr00027842 |
| | | WBCnstr00037184 |
| | Construct_product | WBCnstr00027842 |
| | | WBCnstr00037184 |
| | Microarray_results (30) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032528:L3_depleted |
| | | WBPaper00033065:isp-1-1(qm150)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_larva_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00047132:skn-1(RNAi)_downregulated |
| | | WBPaper00048988:daf-2(e1370)_daf-16(mu86)_downregulated_neuron |
| | | WBPaper00048988:daf-2(e1370)_downregulated_neuron |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056034:pals-25(jy9)_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADL |
| | | WBPaper00061340:ASH |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061466:nath-10(icb99)_downregulated |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00061527:ckr-1-T09B9.3 |
| | | WBPaper00061651:AVF_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064494:postdauer_downregulated_WholeAnimal |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065841:17_0 |
| | | WBPaper00065841:20_0 |
| | | WBPaper00065841:20_1 |
| | | WBPaper00065841:20_2 |
| | | WBPaper00065841:44_0 |
| | | WBPaper00065841:49_0 |
| | | WBPaper00065841:54_0 |
| | | WBPaper00065841:60_0 |
| | | WBPaper00065841:61_0 |
| | | WBPaper00065841:65_0 |
| | | WBPaper00065841:70_1 |
| | | WBPaper00065841:72_0 |
| | | WBPaper00065841:73_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:123_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065841:131_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:eri-1(mg366)_downregulated |
| | | WBPaper00027111:rrf-2(ok210)_downregulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00039851:Live_C_albicans_vs_HK_C_albicans |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated |
| | Interaction (43) |
| Map_info | Map | X | Position | -1.27954 | Error | 0.007914 |
| | Well_ordered |
| | Positive | Positive_clone | C47C12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | raDf2 |
| | | | raDf6 |
| | | | raDf7 |
| | | | raDf9 |
| | Mapping_data | 2_point | 1828 |
| | | Multi_point | 789 |
| | | | 1202 |
| | | | 1203 |
| | | | 1337 |
| | | | 4631 |
| | | Pos_neg_data | 9429 |
| | | | 9431 |
| | | | 9434 |
| | | | 9436 |
| Reference (130) |
| Remark | C47C12.1 was merged into .6. [sdm 11/2000] |
| Method | Gene |
