WormBase Tree Display for Gene: WBGene00000937

WBGene00000937 SMap: S_parent: Sequence: C55B7
  Identity: Version: 2
    Name: CGC_name: dbr-1
      Sequence_name: C55B7.8
      Molecular_name: C55B7.8
        C55B7.8.1
        CE30437
      Other_name: Ce-dbr1 Accession_evidence: EMBL U63636
        let-386 Person_evidence: WBPerson533
        CELE_C55B7.8 Accession_evidence: NDB BX284601
      Public_name: dbr-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 04 Mar 2015 14:21:00 WBPerson2970 Event: Acquires_merge: WBGene00002606
              Name_change: Other_name: let-386
      Acquires_merge: WBGene00002606
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dbr
    Allele (26)
    Legacy_information: [C.elegansII] h117 : mid-larval lethal. OA4: h678, etc. [Howell et al. 1987; KR]
    Strain: WBStrain00023693
      WBStrain00037805
      WBStrain00047004
    RNASeq_FPKM (74)
    GO_annotation (15)
    Contained_in_operon: CEOP1324
    Ortholog (41)
    Structured_description: Concise_description: dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. Paper_evidence: WBPaper00002739
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable RNA lariat debranching enzyme activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in brain disease. Is an ortholog of human DBR1 (debranching RNA lariats 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:15594)
  Molecular_info: Corresponding_CDS: C55B7.8
    Corresponding_transcript: C55B7.8.1
    Other_sequence (20)
    Associated_feature: WBsf664341
      WBsf219594
      WBsf219595
  Experimental_info: RNAi_result: WBRNAi00043233 Inferred_automatically: RNAi_primary
      WBRNAi00024911 Inferred_automatically: RNAi_primary
      WBRNAi00094229 Inferred_automatically: RNAi_primary
      WBRNAi00024912 Inferred_automatically: RNAi_primary
      WBRNAi00094023 Inferred_automatically: RNAi_primary
      WBRNAi00071001 Inferred_automatically: RNAi_primary
      WBRNAi00003245 Inferred_automatically: RNAi_primary
      WBRNAi00090995 Inferred_automatically: RNAi_primary
      WBRNAi00008047 Inferred_automatically: RNAi_primary
      WBRNAi00116813 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1014356
      Expr1030584
      Expr1147212
      Expr2010799
      Expr2029036
    Drives_construct: WBCnstr00037187
    Construct_product: WBCnstr00037187
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061340:DVC_parent
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:dpy-26-B0205.1
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062590:Aging_upregulated_body-wall-muscle
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00034739:N2moreDR1350
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_B
      WBPaper00041002:HF_3d_0.2mM_Down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (51)
  Map_info: Map: I Position: 1.15528 Error: 0.001679
    Well_ordered
    Positive: Positive_clone: C55B7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 2550
      Multi_point: 1036
      Pos_neg_data (13)
    Pseudo_map_position
  Reference: WBPaper00000975
    WBPaper00002739
    WBPaper00002829
    WBPaper00002830
    WBPaper00003985
    WBPaper00038491
    WBPaper00040589
    WBPaper00055090
    WBPaper00064339
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene