WormBase Tree Display for Gene: WBGene00000912
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WBGene00000912 | SMap | S_parent | Sequence | CHROMOSOME_I | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info (13) | |||||||
Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00064218 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 07 Nov 2022 00:00:00 | ||||||
DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00045313 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 27 Jan 2015 00:00:00 | ||||||
Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3821) | |||
DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3821) | ||||
DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3819) | ||||
DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3819,HGNC:3821) | ||||
DOID:4051 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3819) | ||||
DOID:2870 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3821) | ||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3819) | ||||
DOID:3328 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3821) | ||||
Disease_relevance | Parkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species. | Homo sapiens | Paper_evidence | WBPaper00045313 | |||
WBPaper00025083 | |||||||
WBPaper00031384 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 27 Jan 2015 00:00:00 | ||||||
In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior. | Homo sapiens | Curator_confirmed | WBPerson324 | ||||
Modifies_disease | DOID:332 | ||||||
Models_disease_in_annotation | WBDOannot00000340 | ||||||
Modifies_disease_in_annotation | WBDOannot00001226 | ||||||
Models_disease_asserted | WBDOannot00001357 | ||||||
Molecular_info | Corresponding_CDS (11) | ||||||
Corresponding_CDS_history | R13H8.1d:wp144 | ||||||
R13H8.1f:wp214 | |||||||
R13H8.1g:wp274 | |||||||
Corresponding_transcript (11) | |||||||
Other_sequence (36) | |||||||
Associated_feature (54) | |||||||
Gene_product_binds (13568) | |||||||
Transcription_factor | WBTranscriptionFactor000025 | ||||||
Experimental_info (11) | |||||||
Map_info | Map | I | Position | 5.08393 | Error | 0.026229 | |
Well_ordered | |||||||
Positive | Inside_rearr | mgDf50 | |||||
Positive_clone | F55A3 | Author_evidence | Ogg SC | ||||
R13H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 441 | |||||
442 | |||||||
Multi_point | 335 | ||||||
336 | |||||||
2218 | |||||||
3631 | |||||||
3703 | |||||||
3886 | |||||||
4480 | |||||||
4913 | |||||||
Reference (1993) | |||||||
Picture | WBPicture0000013078 | ||||||
WBPicture0000013087 | |||||||
Remark | Related to forkhead/HNF-3 family of winged helix transcription factors [Ogg S] | ||||||
R13H8.1 must be sequence since it is also forkhead. sdm 141100 | |||||||
Method | Gene |