WormBase Tree Display for Gene: WBGene00000872
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| WBGene00000872 | SMap | S_parent | Sequence | F11H8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cyk-1 | Person_evidence | WBPerson75 | |||||
| Sequence_name | F11H8.4 | ||||||||
| Molecular_name | F11H8.4a | ||||||||
| F11H8.4a.1 | |||||||||
| CE47965 | |||||||||
| F11H8.4b | |||||||||
| CE48031 | |||||||||
| F11H8.4b.1 | |||||||||
| Other_name | CELE_F11H8.4 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | cyk-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyk | ||||||||
| Allele (88) | |||||||||
| Possibly_affected_by | WBVar02156884 | ||||||||
| Legacy_information | [Bowerman B] cytokinesis defective. Recessive, maternal-effect, embryonic lethal | ||||||||
| [Stewart HI] homozygotes develop into sterile adults | |||||||||
| [Schnabel H] other name: let-794 NA4 | |||||||||
| Strain | WBStrain00036953 | ||||||||
| WBStrain00000896 | |||||||||
| WBStrain00007271 | |||||||||
| WBStrain00007275 | |||||||||
| WBStrain00007758 | |||||||||
| WBStrain00007791 | |||||||||
| WBStrain00008064 | |||||||||
| WBStrain00008066 | |||||||||
| WBStrain00008065 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00018976 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00019030 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00008848 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016735 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021473 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021698 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | cyk-1 encodes a Formin Homology protein homologous to Drosophila diaphanous and human DIAPH1; cyk-1 is required for embryonic cytokinesis and Arp2/3-independent assembly of cortical microfilaments; CYK-1 physically interacts with the PFN-1 profilin; CYK-1 is enriched within cleavage furrows during cell division. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00005603 | |||||||||
| WBPaper00003167 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 15 Feb 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin binding activity and small GTPase binding activity. Involved in pronuclear migration. Located in actomyosin contractile ring; cleavage furrow; and cytoplasmic side of plasma membrane. Expressed in body wall musculature. Human ortholog(s) of this gene implicated in auditory system disease (multiple) and primary ovarian insufficiency 2A. Is an ortholog of human DIAPH1 (diaphanous related formin 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:5426 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2877) | ||||
| DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2876) | ||||||
| DOID:0080858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2877) | ||||||
| DOID:0060690 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15480) | ||||||
| DOID:0110541 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2876) | ||||||
| Molecular_info | Corresponding_CDS | F11H8.4a | |||||||
| F11H8.4b | |||||||||
| Corresponding_transcript | F11H8.4a.1 | ||||||||
| F11H8.4b.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf992925 | ||||||||
| WBsf992926 | |||||||||
| WBsf992927 | |||||||||
| WBsf992928 | |||||||||
| WBsf1015189 | |||||||||
| WBsf226891 | |||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern | Expr1411 | ||||||||
| Expr11796 | |||||||||
| Expr13168 | |||||||||
| Expr15796 | |||||||||
| Expr1024646 | |||||||||
| Expr1030539 | |||||||||
| Expr1148368 | |||||||||
| Expr1200379 | |||||||||
| Expr2010656 | |||||||||
| Expr2028896 | |||||||||
| Drives_construct | WBCnstr00014831 | ||||||||
| WBCnstr00037232 | |||||||||
| Construct_product | WBCnstr00037232 | ||||||||
| WBCnstr00040234 | |||||||||
| Antibody | WBAntibody00000187 | ||||||||
| WBAntibody00002373 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (116) | |||||||||
| Interaction (104) | |||||||||
| Map_info | Map | III | Position | -0.827588 | Error | 0.008511 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf127 | |||||||
| Positive_clone | F11H8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | sDf125 | |||||||
| sDf135 | |||||||||
| Mapping_data | Multi_point | 3387 | |||||||
| Pos_neg_data | 9594 | ||||||||
| 9612 | |||||||||
| 9631 | |||||||||
| Reference (63) | |||||||||
| Remark | F11H8.4 is a genefinder predicted gene with homology to diaphanous in Drosophila and cdc-12 in S. pombe, both of which are required for cytokinesis | ||||||||
| The mutation s2833 was previously assigned to let-794. | |||||||||
| Method | Gene |
